1971
DOI: 10.1021/ja00748a065
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Effect of a single thymine photodimer on the oligodeoxythymidylate-polydeoxyadenylate interaction

Abstract: Deeming and B. L. Shaw, ibid., 2705 (1970). ( 12) The rate constant for reaction of Ir(CO)(PMe2Ph)«Cl with H2 (in the absence of added PMe2Ph) increases by only a factor of two (from 0.36 to 0.68 M-1 sec-1) in going from chlorobenzene to DMF. Comparably small solvent effects have been found for reactions of H2 with Ir(CO)(PPh3)2Cl and with other Ir1 complexes.4

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Cited by 73 publications
(21 citation statements)
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“…The fragment was constructed by ligating 6 complementary oligomers, one of which contained a thymine dimer (11). When this 48-bp DNA is digested with BamHI and Bgl II restriction enzymes a 32-mer with "sticky ends" is generated (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…The fragment was constructed by ligating 6 complementary oligomers, one of which contained a thymine dimer (11). When this 48-bp DNA is digested with BamHI and Bgl II restriction enzymes a 32-mer with "sticky ends" is generated (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…A synthetic 48-mer duplex with or without a thymine dimer was constructed by ligating 6 complementary oligonucleotides ranging in size from 11 to 17 nucleotides; the central 11-mer contained a cis,syn thymine dimer in one case and normal bases in the other. These 11-mers were labeled with 32P using polynucleotide kinase and therefore the resulting 48-mers contained internal labels.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…This model assumes that the adjacent sites are in the B-form. Figure 3 shows an ORTEPZ7 drawing of the calculated dUp[ ]dU conformer as part of a single-stranded hexameric segment whose other residues are in the B-DNA c o n f~r m a t i o n .~~ The dimer causes a severe bend in the helix, with adjacent base pairs ruptured, according to solution studies (7). Recent experimental resultslsJ9 reveal that pyrimidine[ ]pyrimidine dimers block DNA synthesis in replicating systems, causing a termination site at the locus of the lesion.…”
Section: Results a N D Discussionmentioning
confidence: 99%
“…However, in order to introduce T-T dimer by UV irradiation, more than two thymine residues have to be present as neighbours. Furthermore the formation of one T-T dimer results in an occurrence of 4 mismatched base pairs in hybrids (16). Thus selecting the region used for a probe is very important process.…”
Section: Discussionmentioning
confidence: 99%