Effect of acarbose on insulin sensitivity in elderly patients with diabetes.

Meneilly, Graydon S.; Ryan, E. A.; Radziuk, J.; Lau, Darren; Yale, Jean‐François; Morais, Jennifer Beatriz Silva; Chiasson, Jean‐Louis; Rabasa‐Lhoret, Rémi; Maheux, Pierre; Tessier, Daniel; Wolever, Thomas M. S.; Josse, Robert G.; Elahi, Dariush

doi:10.2337/diacare.23.8.1162

Cited by 124 publications

(67 citation statements)

References 20 publications

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“…It is known that α-glucosidase inhibitors improve insulin resistance. [10][11][12] These findings suggest that the antidiabetic activity of TZ is derived, at least in part, from an improvement of insulin resistance, due to reduction of α-glucosidase activity.…”

Section: Discussionmentioning

confidence: 89%

Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice

Wang

Miura

Shi

et al. 2008

JOURNAL OF HEALTH SCIENCE

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The hypoglycemic and hypolipidemic effects of Tangzhiqing (abbreviated TZ) a mixture of Mulberry Leaf, Lotus Leaf, Danshen Root, and Hawthorn Leaf, were investigated in KK-Ay mice, an animal model of type 2 diabetes. TZ reduced blood glucose, total cholesterol, and triglyceride levels of KK-Ay mice at 4 weeks after oral administration. TZ also improved sucrose or maltose tolerance. Maltase activity in small intestine significantly decreased in the TZtreated KK-Ay mice. These results support the hypothesis that TZ improves glucose metabolism by reducing α-glycosidase activity. Therefore TZ might have beneficial effects on hyperglycemia and hyperlipidemia in type 2 diabetes.

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Section: Discussionmentioning

confidence: 89%

Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice

Wang

Miura

Shi

et al. 2008

JOURNAL OF HEALTH SCIENCE

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“…This is probably caused by the effect of miglitol because miglitol alone resulted in a decrease in postprandial plasma insulin AUC of Ϫ72.8 Ϯ 21.9 pmol ⅐ h/l. The reduction in postprandial plasma glucose and insulin could result in improved insulin sensitivity, as we have shown in elderly type 2 diabetic subjects with acarbose treatment (30).…”

Section: Conclusion -Previous Studiesmentioning

confidence: 79%

The Synergistic Effect of Miglitol Plus Metformin Combination Therapy in the Treatment of Type 2 Diabetes

Chiasson

Naditch

2001

Diabetes Care

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OBJECTIVE -To investigate the efficacy and safety of miglitol in combination with metformin in improving glycemic control in outpatients in whom type 2 diabetes is insufficiently controlled by diet alone.RESEARCH DESIGN AND METHODS -In this multicenter, double-blind, placebocontrolled study, 324 patients with type 2 diabetes were randomized, after an 8-week placebo run-in period, to treatment with either placebo, miglitol alone, metformin alone, or miglitol plus metformin for 36 weeks. The miglitol was titrated to 100 mg three times a day and metformin was administered at 500 mg three times a day. The primary efficacy criterion was change in HbA 1c from baseline to the end of treatment. Secondary parameters included changes in fasting and postprandial plasma glucose and insulin levels, serum triglyceride levels, and responder rate.RESULTS -A total of 318 patients were valid for intent-to-treat analysis. A reduction in mean placebo-subtracted HbA 1c of Ϫ1.78% was observed with miglitol plus metformin combination therapy, which was significantly different from treatment with metformin alone (Ϫ1.25; P ϭ 0.002). Miglitol plus metformin also resulted in better metabolic control than metformin alone for fasting plasma glucose (Ϫ44.8 vs. Ϫ20.4 mg/dl; P ϭ 0.0025), 2-h postprandial glucose area under the curve (Ϫ59.0 vs. -18.0 mg/dl; P ϭ 0.0001), and responder rate (70.6 vs. 45.52%; P ϭ 0.0014). All therapies were well tolerated.CONCLUSIONS -In type 2 diabetic patients, miglitol in combination with metformin gives greater glycemic improvement than metformin monotherapy. Diabetes Care 24:989 -994, 2001

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“…Like viscous soluble fibers, these compounds reduce postprandial blood glucose and insulin excursions. Several investigations have reported increased whole-body insulin sensitivity after treatment with an a-glucosidase inhibitor in obese subjects with glucose intolerance (Calle-Pascual et al, 1996;Chiasson et al, 1996;Meneilly et al, 2000), although others have failed to find such an effect (Schnack et al, 1989;Reaven et al, 1990;Jenney et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure

et al. 2006

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Objective: To assess the effects of consuming foods containing oat b-glucan on blood pressure, carbohydrate homeostasis and biomarkers of oxidative stress. Design: A randomized, double-blind, controlled clinical trial. Setting: The trial was conducted at two clinics. Subjects and interventions: Ninety-seven men and women with resting systolic blood pressure 130-179 mm Hg and/or diastolic blood pressure 85-109 mm Hg were randomly assigned to consume foods containing oat b-glucan or control foods for 12 weeks. Resting blood pressures, insulin and glucose values before and after standard breakfast meals, and four biomarkers of oxidative stress were measured before and at the end of the treatment period. Results: Changes from baseline to week 12 in mean peak insulin and incremental area under the insulin curve differed significantly between groups (P ¼ 0.037 and 0.034, respectively), with the b-glucan group showing declines and the control group remaining essentially unchanged. Blood pressure responses were not significantly different between groups overall. However, in subjects with body mass index above the median (31.5 kg/m 2 ), both systolic (8.3 mm Hg, P ¼ 0.008) and diastolic (3.9 mm Hg, P ¼ 0.018) blood pressures were lowered in the b-glucan group compared to controls. No significant differences in biomarkers of oxidative stress were observed between treatments. Conclusions: The results of the present trial suggest beneficial effects of foods containing b-glucan from oats on carbohydrate metabolism, and on blood pressure in obese subjects.

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Effect of acarbose on insulin sensitivity in elderly patients with diabetes.

Cited by 124 publications

References 20 publications

Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice

Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice

The Synergistic Effect of Miglitol Plus Metformin Combination Therapy in the Treatment of Type 2 Diabetes

Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure

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