Effect of Acetate on Serum Lipids in Maintenance Hemodialysis

Savdie, Elliott; Mahony, J. F.; Jh, Stewart

doi:10.1097/00002480-197700230-00099

Cited by 29 publications

(8 citation statements)

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“…Two studies were included on the basis of quasirandomisation solely because their treatments or treatment periods alternated A-B-A-B (Brezin, et al, 1985: Savidie, et al, 1977. The order of treatments was not randomly allocated.…”

Section: Potential For Selection Bias At Trial Entrymentioning

confidence: 99%

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

MacLeod¹,

Grant²,

Donaldson³

et al. 1998

Health Technology Assessment

140

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Section: Potential For Selection Bias At Trial Entrymentioning

confidence: 99%

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

MacLeod¹,

Grant²,

Donaldson³

et al. 1998

Health Technology Assessment

140

View full text Add to dashboard Cite

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“…Feeding large quantities of acetate to rats and rabbits together with a high-cholesterol diet did not increase the degree of atherosclerosis produced (17). Substitution of bicarbonate for acetate as the alkalinizing agent in hemodialyzed humans did not result in any significant differences in plasma triglyceride or cholesterol contents of the VLDL, LDL, or HDL lipoproteins (18,19). These studies, however, were short term, and since there is definite incorporation of acetate into all these fractions, it is possible that more subtle changes operating over longer time periods may still aggravate atherogenesis.…”

Section: Discussionmentioning

confidence: 98%

Conversion of Acetate to CO₂, Lipids, Proteins, and Lipoproteins during Hemodialysis in Humans

Morin

Davidson

1984

Uremia Investigation

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Acetate-1-14C or acetate-2-14C was infused into the venous dialysis line in 17 chronic stable patients over a 4-hr period of standard hemodialysis. Radioactive CO2 in expired air was measured continuously during dialysis and for 20 hr postdialysis. Significantly more acetate-1-14C (56 +/- 2%) was recovered as 14CO2 in the expired air than was acetate-2-14C (49 +/- 3%). A total of 81% and 71% of the radioactivity was recovered from the expired air and expended dialysate from acetate-1-14C and acetate-2-14C, respectively. Of the remainder, a significant portion was incorporated into plasma lipids and proteins. Incorporation of radioactivity into phospholipids, cholesterol esters, and triglycerides increased during dialysis and continued to increase during the postdialysis period. Free fatty acid radioactivity increased during dialysis but declined afterwards. In the lipoprotein fractions radioactivities remained elevated at 24 hr in the LDL and HDL fractions, but declined in the VLDLs after this time interval.

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“…On the other hand, no clear effect on blood lipids has been recently reported after replacement of dialysate acetate with bicarbonate for 3-5 weeks [36]. However, it is to be considered that serum triglyceride content is increased by uremia per se in nondialyzed patients as well, chiefly as a consequence of an impaired lipoprotein catabolism [1,17].…”

Section: Discussionmentioning

confidence: 98%

Acetate Intolerance in Chronic Uremic Patients

Guarnieri

Carretta

Toigo

et al. 1979

Nephron

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The metabolic effects of an acute acetate load have been investigated in chronic uremic patients and in controls. The decay rate of blood acetate levels was significantly lower in patients than in controls. Higher levels of blood acetoacetate and 2-oxoglutarate and plasma triglycerides were observed in the patients after the load. No difference was detectable in plasma levels of unesterified fatty acids and cholesterol between the two groups of subjects. Acetate oxidation in citric acid cycle may be reduced in uremia owing to a lack of coenzyme A. These observations raise the possibility that chronic acetate administration with the dialysate induces hypertriglyceridemia and accelerates the development of atherosclerosis in hemodialysis patients.

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Effect of Acetate on Serum Lipids in Maintenance Hemodialysis

Cited by 29 publications

References 0 publications

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

Conversion of Acetate to CO₂, Lipids, Proteins, and Lipoproteins during Hemodialysis in Humans

Acetate Intolerance in Chronic Uremic Patients

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Effect of Acetate on Serum Lipids in Maintenance Hemodialysis

Cited by 29 publications

References 0 publications

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease: systematic reviews.

Conversion of Acetate to CO2, Lipids, Proteins, and Lipoproteins during Hemodialysis in Humans

Acetate Intolerance in Chronic Uremic Patients

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Conversion of Acetate to CO₂, Lipids, Proteins, and Lipoproteins during Hemodialysis in Humans