Effect of acetone extract of &lt;i&gt;Rumex japonicas&lt;/i&gt; Houtt on hydrogen peroxide-induced apoptosis in rat myocardial cells

Zhou, Xiaobo; Cao, Kai-Wu; Song, Lingkun; Kou, Shuang-Qing; Qu, Shen-Cheng; Yu, Ying; Liu, Yu; Li, Pengying; Lu, Run-Peng

doi:10.4314/tjpr.v16i1.17

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…The acetone extract of R. japonicus showed protective activity against myocardial apoptosis, through the regulation of oxidative stress levels in cardiomyocytes (LDH, MDA, CK, SOD) and the suppression of the expression of apoptosis proteins (caspase-3, Bax, Bcl-2) on in vitro H 2 O 2 -induced myocardial H9c2 cell apoptosis [175].…”

Section: Other Biological Activitiesmentioning

confidence: 95%

“…To date, 268 compounds including 56 quinones (1-56), 57 flavonoids , 25 tannins , 6 stilbenes (139)(140)(141)(142)(143)(144), 22 naphthalenes (145-166), 6 terpenes (167-172), 3 diterpene alkaloids (173)(174)(175), 14 lignans (176)(177)(178)(179)(180)(181)(182)(183)(184)(185)(186)(187)(188)(189) and 79 other types of components were isolated and reported from 29 Rumex species (Table 2).…”

Section: Chemical Constituentsmentioning

confidence: 99%

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The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

et al. 2022

Nat. Prod. Bioprospect.

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Rumex L., a genus in Polygonaceae family with about 200 species, is growing widely around the world. Some Rumex species, called "sorrel" or "dock", have been used as food application and treatment of skin diseases and hemostasis after trauma by the local people of its growing areas for centuries. To date, 29 Rumex species have been studied to contain about 268 substances, including anthraquinones, flavonoids, naphthalenes, stilbenes, diterpene alkaloids, terpenes, lignans, and tannins. Crude extract of Rumex spp. and the pure isolates displayed various bioactivities, such as antibacterial, anti-inflammatory, antitumor, antioxidant, cardiovascular protection and antiaging activities. Rumex species have important potential to become a clinical medicinal source in future. This review covers research articles from 1900 to 2022, fetched from SciFinder, Web of Science, ResearchGate, CNKI and Google Scholar, using “Rumex” as a search term ("all fields") with no specific time frame set for the search. Thirty-five Rumex species were selected and summarized on their geographical distribution, edible parts, traditional uses, chemical research and pharmacological properties.

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Section: Other Biological Activitiesmentioning

confidence: 95%

Section: Chemical Constituentsmentioning

confidence: 99%

The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

et al. 2022

Nat. Prod. Bioprospect.

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“…The findings indicated RJH mitigated the trend of outflow of CK and LDH from the cytoplasm by H 2 O 2 ‐induced cell membrane damage; Intriguingly, the levels of superoxide dismutase and catalase were dramatically mounting at the concentration of 100 and 200 μg/mL while malondialdehyde level was dropping after RJH treatment at the concentration of 50, 100, and 200 μg/mL; As apoptotic‐related proteins, after RJH treatment, the expression of caspase‐3 and Bax was downregulated while the Bcl‐2 expression was upregulated. Taken together, acetone extract of RJH reverses the myocardial apoptosis in H 2 O 2 ‐induced H9c2 cells under the probable mechanism of inhibition of oxidative stress and mitochondria‐mediated apoptosis (Zhou et al, ).…”

Section: Resultsmentioning

confidence: 99%

Rumex japonicusHoutt.: A phytochemical, pharmacological, and pharmacokinetic review

Sun

Lenon

Yang

2019

Phytotherapy Research

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Rumex japonicus Houtt. (RJH‐Yang Ti) RJH has been used as a folk medicine in East Asian countries for thousands of years. It has a wide range of therapeutic effects in terms of anti‐microorganic, anti‐oxidant, anti‐inflammatory, and antitumor effects. Therefore, it is urgent to thoroughly review the existing knowledge for this herb from phytochemical, pharmacological, and pharmacokinetic perspectives. “Yang Ti” and its English, botanical and pharmaceutical names used as keywords to perform database search which included the Encyclopaedia of traditional Chinese Medicines, PubMed, EMBASE, AMED, CINAHL, Cochrane Library, MEDLINE, Science Direct, Scopus, Web of Science, and China Network Knowledge Infrastructure. Forty‐five compounds identified from RJH. Besides, the therapeutic effects of RJH have been summarized as well. The root of RJH contains derivatives of anthraquinones, phytosterols, nepodin, oxanthrone c‐glycosides, phenolic acid, cinnamic acid, flavonoid, epoxynaphthoquinol, triterpenoids, methoxynaphthalene, trihydroxybenzene, anthracene‐9,10‐dione, and other compounds. The extract of RJH and its chemical compounds showed the potentials as a complementary agent to exert antioxidant, antimicrobial, antisepsis, anticancer, anti‐haematological disease, anti‐dermatological disease, and antidiabetic activities. For the record, there is no study conducted on RJH regarding its pharmacokinetic aspect. Notably, Emodin may require additional attention due to its multiple organ toxicity concerns.

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“…Previous reports have shown that natural extracts/compounds from plants are important resources for finding novel and effective drugs to treat various intractable diseases [16][17][18]. Flavones are reported to possess significant pharmacological activities including anti-sterility, anti-inflammatory, and anti-cancer activities [19,20].…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>Bushen yixue</i> decoction on follicular development in experimental androgen-sterilized anovulatory rats and its possible mechanism of action

Liu¹,

Tang²,

Qu³

et al. 2018

Trop. J. Pharm Res

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Purpose: To explore the activities of Bushen yixue decoction (BSY) against follicular development in anovulatory rats. Methods: Rats were divided into normal, normal control, clomifene citrate (positive control, orally, 5 mg/kg), and BSY (orally, 50, 100, 200 mg/kg) groups. Anovulatory rats were prepared by testosterone propionate injection (1.5 mg/rat). After 70 days, daily vaginal smears were performed for 10 days until no obvious sexual cycle was observed, indicating that androgen-sterilized anovulatory rats were successfully established. High performance liquid chromatography (HPLC) was used to analyse BSY chemical composition. Levels of follicular stimulating hormone (FSH), luteinizing hormone (LH), oestradiol (E2), progesterone (P), prolactin (PRL), inhibin (INH), activin (ACT) and follistatin (FS) were determined by radioimmunoassay or enzyme linked immunosorbent assay (ELISA). Western blotting was used to determine Bcl-2, cleaved-caspase-3, Bax, MMP-9 and VEGF in ovarian tissues. Results: BSY increased (p < 0.05) the levels of FSH, LH, E2 (p < 0.05) and ACT, but decreased (p < 0.05) the levels of PRL, INH and FS, relative to control rats. Expressions of VEGF (p < 0.01), MMP-9 (p < 0.05) and Bcl-2 (p < 0.01) were up-regulated by BSY, whereas Bax (p < 0.01) and C-caspase-3 (p < 0.01) were down-regulated. Conclusion: BSY promotes follicular development of anovulatory rats via regulating INH-ACT-FS hormones, VEGF, MMP-9, Caspase-3, Bax, and Bcl-2. Thus, BSY may have the potential to be developed for clinical management of infertility.

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Effect of acetone extract of <i>Rumex japonicas</i> Houtt on hydrogen peroxide-induced apoptosis in rat myocardial cells

Cited by 4 publications

References 17 publications

The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review

Rumex japonicusHoutt.: A phytochemical, pharmacological, and pharmacokinetic review

Effect of <i>Bushen yixue</i> decoction on follicular development in experimental androgen-sterilized anovulatory rats and its possible mechanism of action

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