The impact of Haber-Bosch process on modern agriculture is prodigious. Haber-Bosch process led to invention of chemical fertilizers that powered green revolution, minimized food scarcity, and improved human and animal nutrition. Haber–Bosch process facilitated agricultural productivity in many parts of the world, with up to 60% of crop yield increase attributed solely to nitrogen fertilizer. However, Haber-Bosch fertilizers are expensive, and their poor use efficiency exerts adverse external consequences. In European Union for example, the annual damage of up to € 320 (US$ 372.495) billion associated with chemical fertilizers outweighs their direct benefit to farmers, in terms of crops grown, of up to € 80 (US$ 93.124) billion. A substitute for chemical fertilizers is therefore needed. In this chapter, external costs of chemical fertilizers are highlighted. The capability of liquid fraction of cassava peeling residue digestate to supplant and mitigate pecuniary costs of chemical fertilizers required for production of cassava root is also analyzed and presented. Results indicate that about 25% of fund used to purchase chemical fertilizers required for cassava root production could be saved with the use of liquid fraction of cassava peeling residue digestate. The pecuniary value is estimated at US$ 0.141 (≈ € 0.121) billion for the 2019 global cassava root output. This saving excludes external costs associated with Haber-Bosch fertilizers such as ammonia air pollution, eutrophication, greenhouse gasses emissions, and contamination of potable water supply reserves. Consequently, liquid fraction digestate could reduce the cost of cassava root production, as well as minimize adverse health and environmental consequences attributed to chemical fertilizers.