Effect of Aconitum coreanum polysaccharide and its sulphated derivative on the migration of human breast cancer MDA-MB-435s cell

Zhang, Yandong; Wu, Wei; Kang, Lihua; Yu, Dehai; Liu, Chunshui

doi:10.1016/j.ijbiomac.2017.05.084

Cited by 23 publications

(6 citation statements)

References 23 publications

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“…Preparation of A. coreanum polysaccharide. The A. coreanum polysaccharide (ACP) was prepared by our research team, as previously reported (15). Briefly, the roots of A. coreanum were grinded and defatted with ethanol.…”

Section: Methodsmentioning

confidence: 99%

“…Monosaccharide compositions were identified and quantified using gas chromatography (Gas Chromatograph, GC-2010 Plus; Shimadzu, Beijing, China). Fourier transform infrared spectrum was measured with a Nicolet 5700 FT-IR spectrometer (Thermo Fisher Scientific, Co., Ltd., Shanghai, China) in the frequency range of 400-4,000 cm -1 (15).…”

Section: Methodsmentioning

confidence: 99%

“…and ACP1-s. Physicochemical properties of ACP1 were reported in our previous study (15). Briefly, the carbohydrate content of ACP1 was 96.1%.…”

Section: Physicochemical and Structural Characterization Of Acp1mentioning

confidence: 99%

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Polysaccharide sulphated derivative from Aconitumï¿½coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-κB/Bcl-2 cell apoptotic signaling pathway

Sun

Wang

et al. 2017

Oncol Rep

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In a previous study, our team preliminarily investigated the bioefficacy of an extracted polysaccharide from the medicinal plant Aconitum coreanum (ACP1). In the present study, we further evaluated the antitumor efficacy of an ACP1 sulphated derivative (ACP1‑s) in the human brain glioblastoma U87MG cell line. Cell viability assay and flow cytometry results demonstrated that 400, 800 and 1,600 µg/ml ACP1‑s induced cell growth inhibition and cell apoptosis. We then investigated the underlying molecular mechanism of the ACP1‑s induced cell apoptosis and found that the NF‑κB/Bcl‑2 cell apoptotic signaling pathway was involved. Following treatment with ACP1‑s, the expression of IκB in U87MG cells was significantly upregulated, whereas the level of NF‑κB and the ratio of Bcl‑2/Bax was significantly decreased. The level of cleaved caspase‑3 was increased accordingly. When we introduced exogenous p65 protein into the U87MG cells, the ACP1‑s-induced cell growth inhibition and cell apoptosis were partially neutralized, and the expression of the anti‑apoptotic gene Bcl‑2 was recovered accordingly. These findings suggest the potential value of ACP1‑s as a novel therapeutic agent for the treatment of glioblastoma.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Polysaccharide sulphated derivative from Aconitumï¿½coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-κB/Bcl-2 cell apoptotic signaling pathway

Sun

Wang

et al. 2017

Oncol Rep

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“…Similarly, after sulfate modification of Hypsizigus marmoreus polysaccharide, the inhibition activity of the sulfate polysaccharide derivative on AGS cancer cell growth was increased by 30% . Sulfated Aconitum coreanum polysaccharide significantly inhibited the migration speed of breast cancer cells, MDA-MB-435S, while the original Aconitum coreanum polysaccharides did not have obvious inhibitory effect . Chemical modification of polysaccharides enhances the biological functions of polysaccharides and promotes wider applications of polysaccharides.…”

Section: Polysaccharides and Cancersmentioning

confidence: 95%

“…49 Sulfated Aconitum coreanum polysaccharide significantly inhibited the migration speed of breast cancer cells, MDA-MB-435S, while the original Aconitum coreanum polysaccharides did not have obvious inhibitory effect. 50 Chemical modification of polysaccharides enhances the biological functions of polysaccharides and promotes wider applications of polysaccharides.…”

Section: ■ Polysaccharides and Cancersmentioning

confidence: 99%

Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

Guo

et al. 2022

J. Agric. Food Chem.

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Cancer is the most serious problem for public health. Traditional treatments often come with unavoidable side effects. Therefore, the therapeutic effects of natural products with wide sources and low toxicity are attracting more and more attention. Polysaccharides have been shown to have cancer-fighting potential, but the molecular mechanisms remain unclear. The mammalian target of rapamycin (mTOR) pathway has become an attractive target of antitumor therapy research in recent years. The regulation of mTOR pathway not only affects cell proliferation and growth but also has an important effect in tumor metabolism. Recent studies indicate that dietary polysaccharides play a vital role in cancer prevention and treatment by regulating mTOR pathway. Here, the progress in targeting mTOR signaling by dietary polysaccharides in cancer prevention and their molecular mechanisms are systemically summarized. It will promote the understanding of the anticancer effects of polysaccharides and provide reference to investigators of this cutting edge field.

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In Vitro Antitumor Potential of Sulfated Polysaccharides from Seaweed Caulerpa cupressoides var. flabellata

et al. 2020

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Effect of Aconitum coreanum polysaccharide and its sulphated derivative on the migration of human breast cancer MDA-MB-435s cell

Cited by 23 publications

References 23 publications

Polysaccharide sulphated derivative from Aconitumï¿½coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-κB/Bcl-2 cell apoptotic signaling pathway

Polysaccharide sulphated derivative from Aconitumï¿½coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-κB/Bcl-2 cell apoptotic signaling pathway

Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

In Vitro Antitumor Potential of Sulfated Polysaccharides from Seaweed Caulerpa cupressoides var. flabellata

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