Effect of acoustic stimulation on cell composition of auditory brain structures in Krushinskii-Molodkina rats

Abstract

We studied the effect of acoustic stimulation on cell composition of auditory brain structures in Krushinskii-Molodkina rats. Significant structural changes in the inferior colliculi of rats with high seizure activity were revealed 1 month after acoustic stimulation. Therefore, this brain structure plays a role in the development of audiogenic epileptic activity.

Effects of Stimulation of the Inferior Colliculi in Krushinskii–Molodkina Rats

“…The role of the inferior colliculi in the formation of audiogenic paroxysmal reactions has not been studied in Krushinskii-Molodkina rats, which were developed and have been used in physiological studies in Russia [12,16]. The only data obtained show that convulsive responses to sound stimuli in rats of this strain are followed by decreases in the numbers of cells in the central nucleus of the inferior colliculi [6], while targeted implantation of embryonic striatal or cerebellar tissue into this structure decreased the intensity of audiogenic convulsions [8]. Furthermore, because of the wide use of Krushinskii-Molo dkina rats for studies of the actions of anticonvulsant agents [1, 9,11,[13][14][15]18], there is an urgent need for more concrete explanations of the functional role of the inferior colliculi in the mechanisms of the formation and development of epileptiform convulsive manifestations in animals of this strain, as the similarities in audiogenic seizures between Krushinskii-Molodkina and GEPR rats does not suggest identity in the structural-functional mechanisms of their realization.…”