No abstract

Quantitative analysis of the main cells and interneurons in different layers and fields of Ammon's horn, the hilus, and dentate gyrus was performed two weeks and one month after kindling, i.e., specific electrical stimulation of the ventral hippocampus. At both experimental time points, cells numbers were significantly decreased at all levels of the areas studied except the marginal layer of field CA4. Thus, in this model of experimental epilepsy, the process of epileptogenesis involved both interneurons and main cells in the hippocampus. The possible reorganization of intrahippocampal circuits and their involvement in the increased excitability characteristic of epilepsy are discussed.

We studied the effect of acoustic stimulation on cell composition of auditory brain structures in Krushinskii-Molodkina rats. Significant structural changes in the inferior colliculi of rats with high seizure activity were revealed 1 month after acoustic stimulation. Therefore, this brain structure plays a role in the development of audiogenic epileptic activity.

GABAergic neurons in different fields of the hippocampus and pyriform cortex were examined 2 weeks and 1 month after electric stimulation of the ventral hippocampus. The counts of GABAergic neurons in the studied structures decreased significantly. The most pronounced shifts in the pyriform cortex were found in the central compartment. Decreased number of inhibitory elements in the two major epileptogenic structures attests to appreciable restructuring in the functions of their neuronal circles.