Effect of Acth on Reproductive Organs of Immature Female Northern Grasshopper Mice (Onychomys Leucogaster)

Td, McKinney; Jn, Pasley

doi:10.1530/jrf.0.0410467

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Numerous examples have unquestionably shown the complex interac tions between corticoadrenal products (and ACTH) and gonadotropin stim ulation in both sexes [MacKinney and Pasley, 1974;Wilson and Follet, 1975;Sung et al, 1977;Thieblot et al, 1979], Glucocorticoids, through a direct action on sexual structures or by an indirect inhibitory effect on the hypophysis, modify sexual cycles, ovulation rates and gestation in females. In males, they produce testicular atrophy.…”

Section: Femalementioning

confidence: 99%

Stress-effects in Microcebus murinus

Perret¹

1982

IJFP

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Histological investigations were made over a 10-year period on 164 lesser mouse lemurs that died spontaneously in captivity. The principal lesions found were chronic nephrosis with nephritis which affects 90% of the animals, myocardial necrosis, respiratory insufficiency induced by interstitial pneumonia, fatty changes in the liver, and splenic and gastric lesions. The following are associated with these pathologies: progressive hypothyroidism, stable hypercorticism, slight medulloadrenal hyperactivity, and sexual disorders such as testicular atrophy in males and estrous cycle disturbance or uterine tumor in females. All these data were treated by correspondence analysis; this showed that, except for some rare cases of death which can be attributed to massive parasitic infestation or generalized cancer, the whole captive population of lesser mouse lemurs is suffering from a syndrome that leads to renal insufficiency and death. Most of the observed pathologies are considered as being associated with aging in mammals. But captive Microcebus murinus died between 3 and 4 years of age, whereas their potential life survival is 13 years. Our hypothesis is that these pathologies arise due to an overload of cortico- and medulloadrenal secretions. The above-mentioned hormonal imbalance could be induced by stress factors occurring in captivity, the most important of which would be social stress.

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Section: Femalementioning

confidence: 99%