Effect of acupuncture on gut microbiota in participants with subjective cognitive decline

Wang, Tianqi; Xiao-ying, Yan; Zhou, Qi

doi:10.1097/md.0000000000027743

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…These findings confirmed, for the first time, that MA could effectively regulate the gut microbiota disorder and restore the normal microbiota structure in APP/PS1 mice, as reflected in the downregulation of Proteobacteria and Escherichia-Shigella , as well as the upregulation of Bacteroidetes, and the effect was comparable to that of probiotics. Previous studies have shown that acupuncture can protect the gut microbiota by promoting the growth of Lactobacillus and Bifidobacterium and inhibiting the proliferation of Bacteroides fragilis and Enterococcus , thereby exerting a therapeutic effect on many diseases such as depression and ulcerative colitis ( Savari et al, 2014 ; Ma et al, 2019 ; Hong et al, 2020 ; Liu G. H. et al, 2020 ; Song et al, 2020 ; Wang et al, 2022 ). However, MA showed no significant regulation of the aforementioned flora in our study, which we speculated might be related to the existence of characteristic flora disorders in different diseases.…”

Section: Discussionmentioning

confidence: 99%

Benign regulation of the gut microbiota: The possible mechanism through which the beneficial effects of manual acupuncture on cognitive ability and intestinal mucosal barrier function occur in APP/PS1 mice

Hao

Ding²,

Zhang³

et al. 2022

Front. Neurosci.

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BackgroundGut microbiota dysbiosis and intestinal barrier injury play vital roles in Alzheimer’s disease (AD) onset and development. Our previous studies have demonstrated that manual acupuncture (MA) could improve the cognitive abilities of APP/PS1 mice. However, the effect of MA on the intestinal mucosal barrier and the gut microbiota mechanism through which this effect occurs remain to be clarified.MethodsIn the APP/PS1 manual acupuncture (Am) group, MA was applied in Baihui (GV20), Yintang (GV29), and Zusanli (ST36). Mice in the APP/PS1 antibiotic + manual acupuncture (Aa) group were treated with an antibiotic mixture and MA at the same time. Probiotics were delivered to the APP/PS1 probiotics (Ap) group. Alterations in spatial learning and memory, the gut microbiota, the intestinal barrier function, and the expression of glial fibrillary acidic protein (GFAP), lipopolysaccharide (LPS), and TNF-α were evaluated in each group.ResultsCompared with the C57BL/6 control (Cc) group, cognitive ability was significantly decreased, the gut microbiota structure was obviously disrupted, intestinal barrier integrity was drastically impaired, and the intestinal inflammatory response was enhanced in the APP/PS1 control (Ac) group (P < 0.01). These changes were reversed by MA and probiotics (P < 0.01 or P < 0.05), whereas antibiotics inhibited the benign regulation by MA (P < 0.01 or P < 0.05).ConclusionManual acupuncture can benignly modulate gut microbiota dysbiosis, significantly reduce intestinal inflammation, and effectively alleviate the destruction of the intestinal mucosal barrier in APP/PS1 mice, and the effects are comparable to those of probiotics. The gut microbiota may play an important role in the improvement of the cognitive function and intestinal barrier function by MA.

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Section: Discussionmentioning

confidence: 99%

Benign regulation of the gut microbiota: The possible mechanism through which the beneficial effects of manual acupuncture on cognitive ability and intestinal mucosal barrier function occur in APP/PS1 mice

Hao

Ding²,

Zhang³

et al. 2022

Front. Neurosci.

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“…Although studies on the gut microbiota and acupuncture are lacking, the discovery of the partial relief of dysbiosis in the gut microbiome in MCI by acupuncture [ 24 ] has aroused great interest among researchers. Additionally, genetic markers that predict the progression of MCI are needed so that interventions to prevent AD development can be implemented.…”

Section: Introductionmentioning

confidence: 99%

Exploration of acupuncture therapy in the treatment of MCI patients with the ApoE ε4 gene based on the brain-gut axis theory

Jin

Chai

et al. 2023

BMC Complement Med Ther

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Background Mild cognitive impairment (MCI) is the predementia phase of Alzheimer’s disease (AD). The intestinal microbiome is altered in MCI and AD, and apolipoprotein E (ApoE) ε4 gene polymorphism is a risk factor for the progression of MCI to AD. This study aims to investigate the improvement in cognitive function of MCI patients with and without ApoE ε4 due to acupuncture and the changes in gut microbiota community composition and abundance in MCI. Methods This randomized assessor-blind controlled study will enrol MCI patients with and without the ApoE ε4 gene (n = 60/60). Sixty subjects with the ApoE ε4 gene and 60 subjects without the ApoE ε4 gene will be randomly allocated into treatment and control groups in a 1:1 ratio. Intestinal microbiome profiles will be evaluated by 16 S rRNA sequencing of faecal samples and compared between the groups. Results/conclusions Acupuncture is an effective method to improve cognitive function in MCI. This study will provide data on the relationship between the gut microbiota and the effectiveness of acupuncture in patients with MCI from a new angle. This study will also provide data on the relationship between the gut microbiota and an AD susceptibility gene by integrating microbiologic and molecular approaches. Trial registration www.chictr.org.cn, ID: ChiCTR2100043017, recorded on 4 February 2021.

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“…However, the interaction between gut microbiota and acupuncture treatment has been scarcely investigated. Only one clinical study ( Wang et al, 2022 ) have revealed that dysbiosis was found in the gut microbiome in subjective cognitive decline and partially relieved by acupuncture, Bifidobacterium is positively correlated with clinical efficacy Z-score and Montreal Cognitive Assessment (MoCA) Scale (both P < 0.005). Additionally, it is necessary to conduct systematic research on MCI elderly people to explore the prevention strategy of AD in the future, which can not only understand the evolution process of intestinal flora during and after acupuncture but also provide the basis for making the prevention plan for early cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Exploration of acupuncture therapy in the treatment of mild cognitive impairment based on the brain-gut axis theory

Jin

Zhu

2022

Front. Hum. Neurosci.

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BackgroundMild cognitive impairment (MCI) is an intermediary state between normal aging and dementia. Early intervention for MCI may be a key opportunity in managing dementia. Recent studies have demonstrated the alterations in the gut microbial communities associated with MCI. This study aims to evaluate if acupuncture can improve cognitive function in subjects with MCI and explore the possible mechanism of acupuncture by better defining the interactions of gut microbiota.MethodsA randomized assessor-blind controlled study is proposed. A total of 62 subjects will be recruited and randomly allocated into two groups in a 1:1 ratio: the treatment and control groups. Participants in the treatment group will receive active acupuncture and exercise/cognitive training (conventional treatment). The control group will receive sham acupuncture and exercise/cognitive training. Each participant will receive active or sham acupuncture for 12 weeks. The primary outcome will be the Montreal Cognitive Assessment (MoCA) score and intestinal flora. Secondary outcomes will include mini-mental state examination (MMSE) and activity of daily living (ADL) scores. Various scales will be collected at baseline, during the treatment (weeks 4 and 8), week 12, and months 4 and 6 after the intervention. Feces will be collected before and after the treatment based on 16S rRNA gene sequencing technology for each participant to characterize the intestinal flora. Adverse events will be recorded by monthly follow-up.ResultsThe trial is expected to show that cognitive function can be improved by acupuncture and produce reliable clinical outcomes in MCI patients. It will also provide preliminary data on the possible mechanism based on the changes in the intestinal flora. Collected data will be used to support future large-scale fundamental studies.ConclusionAcupuncture is an effective method to improve cognitive function for MCI. This study will provide data on the relationship between gut microbiota and the effectiveness of acupuncture in patients with MCI from a new angle.Clinical trial registration[www.ClinicalTrials.gov], identifier [MR-33-22-002376].

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Effect of acupuncture on gut microbiota in participants with subjective cognitive decline

Cited by 5 publications

References 34 publications

Benign regulation of the gut microbiota: The possible mechanism through which the beneficial effects of manual acupuncture on cognitive ability and intestinal mucosal barrier function occur in APP/PS1 mice

Benign regulation of the gut microbiota: The possible mechanism through which the beneficial effects of manual acupuncture on cognitive ability and intestinal mucosal barrier function occur in APP/PS1 mice

Exploration of acupuncture therapy in the treatment of MCI patients with the ApoE ε4 gene based on the brain-gut axis theory

Exploration of acupuncture therapy in the treatment of mild cognitive impairment based on the brain-gut axis theory

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