Effect of acute coronary artery ligation upon blood flow to the normal myocardium

Levy, Matthew N.; Cutarelli, Renato; Zieske, Harrison; Nelson, Geraldine

doi:10.1016/0002-9149(64)90221-8

Cited by 12 publications

(6 citation statements)

References 17 publications

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“…(chest closed) 1.24 (5) 0.88 (3) 0.83 (5) 1.40 (4) 1.90 (6) 1.09 (9) 1.20 (6) 1.30 (9) 1.06 1.59 (4) 2.25 (6) 1.15 (9) 1.48 (0) 1.05 (9) 1.17 Number in parentheses is number of measurements. Circumflex is area supplied by circumflex artery.…”

Section: Resultsmentioning

confidence: 99%

“…This is usually attributed to a vasoconstrictor reflex which may be blocked in various ways. However, most recent reports have demonstrated an increase in flow in vessels adjacent to an occluded artery (4)(5)(6)(7)(8)(9)(10)(11)(12). These studies range from acute experiments on anesthetized animals subjected to major surgery to elegant chronic studies of conscious, trained animals with gradually induced coronary obstruction (15).…”

Section: Rees Reddingmentioning

confidence: 99%

“…ADDITIONAL KEY WORDS la;l xenon coronary vasodilator collateral flow circumflex artery anterior descending artery right coronary artery 9 The purpose of this study was to measure blood flow, after occlusion of one coronary artery, to specific parts of the ventricular myocardium with open vessels. Some previous studies indicated a reduction in flow, but more often an increase was found, particularly when blood pressure was kept constant.…”

mentioning

confidence: 99%

“…Some previous studies indicated a reduction in flow, but more often an increase was found, particularly when blood pressure was kept constant. When pressure was allowed to change, flow elsewhere in the heart was usually reduced or unaltered (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

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confidence: 99%

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Experimental Myocardial Infarction in the Dog

Rees

Redding

1969

Circulation Research

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Control measurements of myocardial blood flow were made in intact dogs by a method of 133 Xe clearance, using a catheter positioned radiographically in the circumflex artery. Acute myocardial infarction was then caused by tying the anterior descending artery. A small catheter was inserted distally beyond the obstructed artery into the infarct, and another proximally toward the anterior ventricular artery supplying adjacent left ventricular muscle. Their ends were brought out as the chest was closed. 133 Xe in solution was injected serially over 4 hours to determine myocardial blood flow within the infarct, in adjacent muscle, and in more distant muscle supplied by the circumflex artery. Myocardial blood flow in the circumflex artery usually fell as a result of infarction. A constant finding was that adjacent flow exceeded the more distant flow by 6% up to 43% (mean 20%) regardless of either spontaneous or induced changes in blood pressure. The difference was not related to the collateral flow rate and was abolished by dipyridamole. Perfusion of muscle adjacent to the infarct was less homogenous than that of more distant muscle.In the normal dog rates of myocardial blood flow in the distribution of the circumflex and anterior descending branches of the left coronary artery were the same, contrasting with lower rates for the right. * In arbitrary units from ratio of mean systemic blood pressure to k. f Number of determinations in parentheses. | Mean ± SD; in parentheses, percent of flow in distribution of circumflex artery.Circ. = circumflex artery. Desc. = anterior descending artery. Right = right coronary artery.

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Section: Resultsmentioning

confidence: 99%

Section: Rees Reddingmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Experimental Myocardial Infarction in the Dog

Rees

Redding

1969

Circulation Research

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“…The overwhelming weight of evidence indi cates a compensatory hyperfunction in the region of functional muscle surrounding the infarct. In this region, a 20-25% increase in blood flow [14,20], an increase in oxygen extraction from perfusing flood [6], and an increased contractile response [23] have been reported. Myocardial en zyme studies show an increased phosphorylase during the first few days after an infarct, followed by an increase of up to 170% in activity of enzymes involved in oxidative metabolism of fatty acids [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of Ischemia and Infarction on Regional Content of Adenine Nucleotides and Derivatives in Canine Left Ventricle<sup>1</sup>

1976

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Samples of myocardium from four areas of ischemic and infarcted canine ventricle were examined over a 20-day period for content of the three adenine nucleotides as well as inosine, hypoxanthine, adenosine, and inosine monophosphate. The adenosine triphosphate (ATP) content of central and peripheral areas within the infarct fell to 11% and 8% of control, respectively, 1 day after coronary occlusion. The total adenine nucleotide (TAN) content in these areas fell to 17% of control and showed no significant recovery during the period of study. In the functional myocardium immediately surrounding the infarct the ATP content was depressed to 58% of control after 1 day, and the TAN content was also depressed. In the healthy myocardium near the apex, the ATP content was significantly depressed only at the 3-day sample period. Adenine nucleotide derivatives were detected only at 30 min in the central ischemic area. The absence of the nucleoside and nucleobase compounds formed during adenine nucleotide degradation is attributed to their high membrane diffusibility. Loss of these compounds is considered a contributing factor in the prolonged depression of adenine nucleotide content in both ischemic and non-ischemic regions.

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Cholinergic and Purinergic Regulation of Blood Vessels

Burnstock

1980

Comprehensive Physiology

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Effect of acute coronary artery ligation upon blood flow to the normal myocardium

Cited by 12 publications

References 17 publications

Experimental Myocardial Infarction in the Dog

Experimental Myocardial Infarction in the Dog

Effect of Ischemia and Infarction on Regional Content of Adenine Nucleotides and Derivatives in Canine Left Ventricle<sup>1</sup>

Cholinergic and Purinergic Regulation of Blood Vessels

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