1986
DOI: 10.1172/jci112325
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Effect of acute hypercapnia on renal and proximal tubular total carbon dioxide reabsorption in the acetazolamide-treated rat.

Abstract: The present study evaluates the effect of acute hypercapnia on renal total CO2 (tCO2) reabsorption after inhibition of renal carbonic anhydrase.Simultaneous renal clearance studies and free-flow micropuncture studies of the superficial proximal tubule were performed on plasma-repleted Sprague-Dawley rats treated with acetazolamide, 50 mg/kg body weight. Acute hypercapnia (arterial Pco2, 120 mmHg, blood pH, 7.02) was induced by ventilation with a 10% COr90% 02 gas mixture. Control rats (Pco2, 49.5 mmHg, pH 7.34… Show more

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Cited by 5 publications
(2 citation statements)
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“…Surprisingly, little is known about TCO 2 in patients with dyspnea at the ED, its prognostic value, and its impact on patient outcome. The mechanisms causing dyspnea are still incompletely understood [1], and the knowledge of which factors contribute to the blood concentration of TCO 2 is largely based on experimental animal studies and theoretical conclusions [29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…Surprisingly, little is known about TCO 2 in patients with dyspnea at the ED, its prognostic value, and its impact on patient outcome. The mechanisms causing dyspnea are still incompletely understood [1], and the knowledge of which factors contribute to the blood concentration of TCO 2 is largely based on experimental animal studies and theoretical conclusions [29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…For example, in response to acute respiratory acidosis (i.e., a rise in PCO 2 that causes a fall in pH), the kidney rapidly stimulates H ϩ secretion, as shown in the 1950s by Relman et al (62), Brazeau and Gilman (10), and Dorman et al (21). The response occurs even in the denervated kidney (81). Moreover, acute respiratory alkalosis inhibits H ϩ secretion (45).…”
mentioning
confidence: 97%