Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Feneley, Michael P.; Olsen, Craig O.; Glower, Donald D.; Rankin, J S

doi:10.1161/01.res.65.1.135

Cited by 42 publications

(24 citation statements)

References 45 publications

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“…10 , 22 , 31 The cause of the RV PV loop rightshift is similar to the situation with the ischemic LV. The higher pulmonary valve impedance causes a lower RV stroke volume.…”

Section: Physiological Resultsmentioning

confidence: 90%

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Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

et al. 2006

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In this study we present a novel, robust method to couple finite element (FE) models of cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac phase. For each time step through a cardiac cycle, left and right ventricular pressures were calculated using ventricular compliances from the FE and CIRC models. These pressures served as boundary conditions in the FE and CIRC models. In succeeding steps, pressures were updated to minimize cavity volume error (FE minus CIRC volume) using Newton iterations. Coupling was achieved when a predefined criterion for the volume error was satisfied. Initial conditions for the multi-scale model were obtained by replacing the FE model with a varying elastance model, which takes into account direct ventricular interactions. Applying the coupling, a novel multi-scale model of the canine cardiovascular system was developed. Global hemodynamics and regional mechanics were calculated for multiple beats in two separate simulations with a left ventricular ischemic region and pulmonary artery constriction, respectively. After the interventions, global hemodynamics changed due to direct and indirect ventricular interactions, in agreement with previously published experimental results. The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system.

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“…10 , 22 , 31 The cause of the RV PV loop rightshift is similar to the situation with the ischemic LV. The higher pulmonary valve impedance causes a lower RV stroke volume.…”

Section: Physiological Resultsmentioning

confidence: 90%

“…The LV and RV pressures are updated using Newton's method, where the residual R ⃗ is minimized: (10) in which (11) is the derivative of the residual (Eq. 6) with respect to LV and RV pressures.…”

Section: Updating the Cavity Pressuresmentioning

confidence: 99%

Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

et al. 2006

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“…The positioning of this orthogonal array of transducers has been described in detail previously. 2,8 In the three isolated, perfused hearts and in four of the eight arrested hearts, an additional orthogonal array of two pairs of regional cylindrical crystals (1.5 mm o.d.) was positioned in the subepicardial midportion of the right ventricular free wall.…”

Section: Methodsmentioning

confidence: 99%

Ellipsoidal shell subtraction model of right ventricular volume. Comparison with regional free wall dimensions as indexes of right ventricular function.

Feneley

Elbeery

Gaynor

et al. 1990

Circulation Research

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Pulse-transit sonomicrometry was used to measure the base-apex (a), anteroposterior (b), and septal-free wall (c) diameters of the left ventricle and the septal-free wall diameter of the right ventricle (d) in eight excised and three isolated, pump-perfused canine heart preparations, as well as in nine conscious dogs. In the three perfused hearts and in four of the excised hearts, right ventricular free wall regional segment lengths and segment area also were assessed. Biventricular volumes were measured directly with intracavitary balloons in all isolated hearts. When left ventricular balloon volume was held constant, relations between right ventricular free wall dimensions and right ventricular balloon volume were highly linear. With increments in left ventricular volume, however, these relations remained linear but shifted progressively upward, indicating an independent relation between right ventricular free wall dimensions and left ventricular cavitary volume. An ellipsoidal shell subtraction model (pi/6.abd minus right ventricular free wall volume) was developed to estimate right ventricular cavitary volume from cardiac dimensions. With this method, a highly linear relation was observed between calculated right ventricular volume and right ventricular balloon volume (mean r = 0.99 +/- 0.01). Moreover, this relation appeared to be independent of changes in left ventricular balloon volume. With the shell subtraction model, dynamic right ventricular volume was computed in nine conscious dogs, and in four, stroke volume derived from dimensions was compared with right ventricular stroke volume measured with ultrasonic flow probes. A highly linear relation was observed, suggesting the accuracy of the shell subtraction method in vivo. Right ventricular end-systolic pressure-volume and stroke work/end-diastolic volume relations then were evaluated, and both proved to be highly linear in the right ventricle (both mean r = 0.99 +/- 0.01). Thus, the shell subtraction model allows a simple estimate of dynamic right ventricular volume in the intact heart and facilitates assessment of right ventricular performance in vivo.

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“…In myocardial infarction, a large portion of the left ventricular wall may become stiff and scarred with no active function. Increased diastolic filling of one ventricle impedes filling of the other [18]. Direct interaction between right and left ventricles during systole has been shown to affect ventricular contraction and relaxation in the intact heart under normal conditions [70].…”

Section: Introductionmentioning

confidence: 99%

Finite Element Modeling of Ventricular Mechanics

Guccione

McCulloch

1991

Institute for Nonlinear Science

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Computing the distributions of stress and strain in a body with the complex geometry, boundary conditions, and material properties of the heart is a difficult yet worthwhile endeavor. The most promising method for obtaining numerical solutions to this problem is the finite element method. In this chapter, we review the use of finite element analysis for modeling ventricular mechanics. And we conclude by presenting a new axisymmetric finite element model of the passive left ventricle with a realistic geometry and fibrous architecture, physiological boundary conditions, and a three-dimensional constitutive equation. IntroductionThe distributions of stress in the ventricles of the heart are determined by (1) the three-dimensional geometry and fibrous architecture of the ventricular walls, (2) the boundary conditions imposed by the ventricular cavity and pericardial pressures and structures like the fibrous valve ring skeleton at the base of the ventricles, and (3) the three-dimensional mechanical properties of the myofibers and their collagen interconnections in the relaxed and actively contracting states. Many of these determining factors have been quantified in experimental studies, some of which are described in detail in this book.For example, Streeter and Hanna [72,73] and Nielsen and coworkers [56] have made detailed studies of the three-dimensional geometry and myocardial fiber architecture of the ventricles of the dog heart. Measurements of left and right ventricular pressures in patients are quite routine. And extensive data have been collected on the passive and active uniaxial material properties of isolated papillary muscles and trabeculae from various mammalian species [64,74]. Although fully triaxial material testing still presents significant technical difficulties, biaxial stress-strain testing of excised two-

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Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Cited by 42 publications

References 45 publications

Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

Ellipsoidal shell subtraction model of right ventricular volume. Comparison with regional free wall dimensions as indexes of right ventricular function.

Finite Element Modeling of Ventricular Mechanics

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