Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution

Desai, P.R; Jain, Neeraj; Sharma, Rakesh; Bahadur, Pratap

doi:10.1016/s0927-7757(00)00493-3

Cited by 271 publications

(213 citation statements)

References 53 publications

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“…However, above the CMT, the I 372 / I 385 ratio dropped to a lower level, as the pyrene partition changed to a more hydrophobic environment as micellar aggregation began to form. These results were comparable with the CMT of pure F127 (23°C) in the literature, 22,23 which meant that the F127-MNPs was more hydrophobic above 25°C.…”

Section: Morphology and Characterization Of F127-shellsupporting

confidence: 87%

“…[17][18][19][20][21][22][23] Some of these systems, e.g., thermoreversible gels, have been based on the existence of a lower critical solution temperature (LCST), or critical micellization temperature (CMT), and have usually been applied as intelligent drug carriers. [17][18][19][20][21][22][23] Poly(N-isopropylacrylamide) (PNIPAAm), poly-(ethylene glycol)-poly(lactic acid)-poly(ethylene glycol) triblocks (PEG-PLA-PEG), and poly(ethylene oxide)-poly-(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblocks have been among the most important reverse thermal gelation-displaying polymers. These triblocks, especially Poloxamer 407, also known by the trade name Pluronic F127 (PEO 100 -PPO 65 -PEO 100 ), have been investigated for wound covering and controlled drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, Pluronic series copolymer has excellent biocompatibility and is one of the very few synthetic polymers approved by the US Food and Drug Administration (FDA) for use as a food additive and pharmaceutical ingredient. 22,23 Pluronic series copolymer is also a potential candidate for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Instantaneous Drug Delivery of Magnetic/Thermally Sensitive Nanospheres by a High-Frequency Magnetic Field

Liu

Hu²,

Liu³

et al. 2008

Langmuir

106

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Novel dual-functional nanospheres composed of magnetic iron oxide nanoparticles embedded in a thermo-sensitive Pluronic F127 (F127) matrix were successfully synthesized by an in situ coprecipitation process. The nanospheres were characterized by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. Experimental observations indicated that the F127 was subjected to a rapid structural change when the magnetic phase caused rapid heating after a short exposure to a high-frequency magnetic field. During the field duration, considerable volume shrinkage of the nanospheres (2.3-fold diameter reduction) was detected. This has been translated to an instantaneous release of a drug, Doxorubicin (DOX), when the DOX was encapsulated within the nanospheres. Such a rapidly responsive release of the DOX from the nanospheres was due to an intimate contact between the nanomagnet and F127, where an effective thermal and mechanical transfer between core and shell phases efficiently took place in the presence of the magnetic field.

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Section: Morphology and Characterization Of F127-shellsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Instantaneous Drug Delivery of Magnetic/Thermally Sensitive Nanospheres by a High-Frequency Magnetic Field

Liu

Hu²,

Liu³

et al. 2008

Langmuir

106

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“…of the P123 surfactants, and thus fail to serve as the template for mesoporous SBA-15. 15 In the current case, we propose that the doping of PPO blocks with alkanes may suppress the hydration of the hydrophobic PPO blocks, and therefore the corresponding c.m.c. of the surfactant is lower at low temperatures.…”

mentioning

confidence: 90%

“…11 Moreover, it is reported that the PPO moieties of the P123 show increasing hydrophilic tendency with the decrease of temperatures, which results in no aggregation of surfactants at lower temperatures. 15 Therefore, the condensation of the inorganic-organic hybrid surfactant monomers at relatively lower temperatures, i.e. room temperature, often leads to amorphous silica gel.…”

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confidence: 99%

Alkanes-assisted low temperature formation of highly ordered SBA-15 with large cylindrical mesopores

et al. 2005

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Highly ordered SBA-15 silicas with large cylindrical mesopores (y15 nm) are successfully obtained with the help of NH 4 F by controlling the initial reaction temperatures in the presence of excess amounts of alkanes.With the discovery of M41s, 1 great efforts have been made on the construction of texture controllable mesoporous materials. Among them, tailoring the pore size of the mesoporous materials has been one of the hot issues for the purpose of providing a good performance for specific applications, such as the adsorption/ separation of bulky molecules, the immobilization of enzymes as well as the catalytic transformation reactions of macromolecules, etc. Methods to modify the pore size of the mesoporous materials include the post synthesis treatment, 2 using different surfactant molecules (template) with different chain lengths 3 and employing organic solvents as swelling agents. 4 The addition of swelling agents, such as TMB, alkanes, 5,6 has been proved to be the most effective way in expanding the pore size of MCM-41 silicas (2-10 nm). Recently, the nonionic triblock copolymers templated SBA-15 silicas have attracted great interests due to their larger pores, thicker pore walls and therefore higher hydrothermal stabilities. 7 Meanwhile, the pore size of SBA-15 could be tuned in the range of 7-30 nm by using TMB as expander. However, extensive studies show that a phase transition from highly ordered SBA-15 (7-12 nm) to mesoporous cellular foams (MCF) with large nodded pore structures (y22-42 nm) occurred with increasing amounts of TMB. 8 Therefore, it is still essential to find other methods of tuning the pore size of highly ordered mesoporous materials. In other works, organic auxiliary chemicals (e.g., DMF, 9 alkanes 10,11 ) have also been investigated. Unfortunately, the maximum pore size of the highly ordered SBA-15 is only ca. 12 nm (with decane). Furthermore, when alkanes with shorter chain length (such as nonane, octane, etc.) were employed, disordered MCF silicas were produced under the temporal reaction conditions. 10 Up to now, to our knowledge, the synthesis of highly ordered SBA-15 silicas with cylindrical pore sizes larger than 12 nm has rarely been reported. Herein, it is demonstrated for the first time that the pore size of highly ordered SBA-15 could be continuously expanded to y15 nm by carefully controlling the initial reaction temperatures with excess amounts of alkanes (from nonane to hexane). To our knowledge, it is the largest cylindrical mesopore diameter with regard to highly ordered SBA-15 silicas.As a typical synthesis procedure, 2.4 g of EO 20 PO 70 EO 20 (P123) was dissolved in 84 ml HCl solution (1.30 M), followed by the addition of 0.027 g of NH 4 F. The mixture was then stirred at 288 K to yield a clear solution. Different alkanes (with a constant alkane/P123 molar ratio of y240) and 5.5 ml TEOS were premixed and then introduced into the solution under stirring. The above mixture was stirred at a given temperature for 20 h, and then transferred into an autoclave for furthe...

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High-Yield Synthesis of Periodic Mesoporous Silica Rods and Their Replication to Mesoporous Carbon Rods

et al. 2002

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Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution

Cited by 271 publications

References 53 publications

Instantaneous Drug Delivery of Magnetic/Thermally Sensitive Nanospheres by a High-Frequency Magnetic Field

Instantaneous Drug Delivery of Magnetic/Thermally Sensitive Nanospheres by a High-Frequency Magnetic Field

Alkanes-assisted low temperature formation of highly ordered SBA-15 with large cylindrical mesopores

High-Yield Synthesis of Periodic Mesoporous Silica Rods and Their Replication to Mesoporous Carbon Rods

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