Effect of Adenosine Deaminase Inhibitors on the Heartʼs Functional and Biochemical Recovery from Ischemia

Dhasmana, Janardan P.; Digerness, Stanley B.; Geckle, J. M.; Ng, Thian C.; Glickson, Jerry D.; Blackstone, Eugene H.

doi:10.1097/00005344-198311000-00019

Cited by 45 publications

(10 citation statements)

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“…We previously found that enhanced A 1 AR activity selectively limits diastolic injury in this model [4,38]. While inhibition of protection in ADA deficient hearts by simultaneous A 1 AR deletion agrees with pharmacological data supporting ARdependent protection with ADA inhibition [4], other processes may contribute to protection, including reduced xanthine oxidase derived ROS [5,34] and enhanced purine salvage [32]. In terms of xanthine oxidase, our data show this reaction remains active and will still generate considerable ROS in ADA deficient hearts (Fig.…”

Section: Effects Of Ada Deficiency On Ischaemic Tolerance and Purine supporting

confidence: 87%

“…Prior studies employing pharmacological agents support enhanced ischaemic tolerance when ADA activity is acutely suppressed [4,32,33]. This may arise from enhanced adenosine and AR activation [4], purine salvage [32], reduced xanthine oxidase activity [5,34], or non-specific effects of inhibitors (including phosphodiesterase inhibition) [1,35].…”

Section: Effects Of Ada Deficiency On Ischaemic Tolerance and Purine mentioning

confidence: 99%

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Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Willems

Reichelt

Molina

et al. 2006

Cardiovascular Research

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Deficiency of ADA does not alter sensitivities of cardiovascular A1 or A2ARs (despite markedly elevated [adenosine]), but significantly improves ischaemic tolerance. Conversely, A1AR deficiency impairs ischaemic tolerance. Effects of ADA deficiency on diastolic pressure appear solely A1AR-dependent while other ARs or processes additionally contribute to improved contractile recovery and reduced cell death.

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Section: Effects Of Ada Deficiency On Ischaemic Tolerance and Purine supporting

confidence: 87%

Section: Effects Of Ada Deficiency On Ischaemic Tolerance and Purine mentioning

confidence: 99%

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Willems

Reichelt

Molina

et al. 2006

Cardiovascular Research

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“…Their hearts were rapidly excised, placed in cold buffer and perfused retrogradely via the aorta. 16 The Hepes perfusion buffer contained (in mM): Hepes, 6; NaCl, 144; CaC12, 2.5; MgC12, 0.9; KCI, 6 and glucose, 11 and was continuously equilibrated with 100% oxygen. Perfusate flow was maintained constant at 15mL/min by a Masterflex peristaltic pump (Cole Palmer, Inc., Chicago, IL, USA).…”

Section: H E a R T Perfusionmentioning

confidence: 99%

³¹P chemical shift imaging of the regionally ischemic perfused heart

Chatham

Blackband

1990

NMR in Biomedicine

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The application of one-dimensional 31P chemical shift imaging to the study of the isolated perfused rat heart is described. Its applicability for the examination of regional ischemia in the isolated perfused rat heart is demonstrated. The data sets show clearly the localization to the ischemic and nonischemic regions of the heart. Such studies will permit the correlation of cardiac metabolism and function in a controlled manner that is not possible in the application of these techniques to the intact animal. In particular, the time resolution of the experiments will enable spatially localized metabolic studies to be performed during the onset of ischemia and during reperfusion.

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“…Formula 1 was obtained from the Henderson-Hassclbalch relation ship for the pH and concentration of the H ' free ions [7], The com pounds observed and identified from the 11P MRS spectra were PCr. adenosine triphosphate (ATP), inorganic phosphate (P,), phosphomonoester (PME).…”

Section: Introductionmentioning

confidence: 99%

Altered Muscle Metabolism in Pustular Psoriasis (Zumbusch Type) Demonstration by <sup>31</sup>P Magnetic Resonance Spectroscopy

et al. 1993

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We report a patient with pustular psoriasis (Zumbusch type) with diffuse muscle pain. Evaluation of skeletal muscle metabolism during rest, graded levels of exercise and recovery was performed using ³¹phosphor magnetic resonance spectroscopy (³¹P MRS). Our results underline the systemic character of severe pustular psoriasis. The clinical improvement after drug therapy (prednisolone and etretinate) correlated well with the measurable changes in vivo of several metabolites and indices important in muscle contraction, such as phosphocreatine (PCr), inorganic phosphate (P_i), intramuscular pH and the phosphorylation potential (PCr/P_i). Abnormal accumulation of sugar phosphates (phosphomonoester) as well as their slow resolution during recovery reflect profound alteration of metabolism in the sense of block in glycolysis. Our results show that ³¹P MRS is well suited to identify and measure subtle changes in the muscle metabolism occurring in pustular psoriasis.

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Effect of Adenosine Deaminase Inhibitors on the Heartʼs Functional and Biochemical Recovery from Ischemia

Cited by 45 publications

References 0 publications

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

³¹P chemical shift imaging of the regionally ischemic perfused heart

Altered Muscle Metabolism in Pustular Psoriasis (Zumbusch Type) Demonstration by <sup>31</sup>P Magnetic Resonance Spectroscopy

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Effect of Adenosine Deaminase Inhibitors on the Heartʼs Functional and Biochemical Recovery from Ischemia

Cited by 45 publications

References 0 publications

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

31P chemical shift imaging of the regionally ischemic perfused heart

Altered Muscle Metabolism in Pustular Psoriasis (Zumbusch Type) Demonstration by <sup>31</sup>P Magnetic Resonance Spectroscopy

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³¹P chemical shift imaging of the regionally ischemic perfused heart