Effect of adrenalectomy on correlation of analgesia with tissue content of morphine

Miyamoto, Yoshiyuki; Yamamoto, Hiroyuki

doi:10.1016/0014-2999(89)90742-5

Cited by 13 publications

(3 citation statements)

References 14 publications

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“…In this regard, the elimination of hypothalamus‐pituitary‐adrenal function through adrenalectomy potentiated the antinociceptive effect of nifedipine, a calcium channel blocker and attenuated its analgesic tolerance (Mahani et al., ). Miyamoto et al () also reported that adrenalectomy potentiated the antinociception of subcutaneous injected morphine, and potentiated the synergistic interaction of supraspinal and spinal morphine action. In this study, we also demonstrated that the adrenalectomy can significantly enhance exogenous corticosterone‐induced antinociceptive effects in formalin test, while it does not affect normal responses of formalin‐induced nociception.…”

Section: Discussionmentioning

confidence: 94%

Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Kang

Roh

Kim

et al. 2013

European Journal of Pain

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Section: Discussionmentioning

confidence: 94%

Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Kang

Roh

Kim

et al. 2013

European Journal of Pain

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“…In this regard, elimination of HPA axis function through adrenalectomy potentiates the antinociceptive effect of the calcium channel blocker, nifedipine, and attenuates its analgesic tolerance [24]. It has been reported that adrenalectomy potentiates morphine sensitivity at the level of the spinal cord and also potentiates the synergistic interaction of supraspinal and spinal morphine action [25]. Moreover, the adrenal medulla is also implicated in vagotomy's pain facilitatory mechanisms, and this hyperalgesic action is reversed by denervation of the adrenal medulla [26].…”

Section: Discussionmentioning

confidence: 99%

Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test: Involvement of Peripheralβ-Adrenoceptors

Kang

Roh

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The injection of diluted bee venom (DBV) into an acupoint has been used traditionally in eastern medicine to treat a variety of inflammatory chronic pain conditions. We have previously shown that DBV had a potent antinociceptive efficacy in several rodent pain models. However, the peripheral mechanisms underlying DBV-induced antinociception remain unclear. The present study was designed to investigate the role of peripheral epinephrine on the DBV-induced antinociceptive effect in the mouse formalin assay. Adrenalectomy significantly enhanced the antinociceptive effect of DBV during the late phase of the formalin test, while chemical sympathectomy had no effect. Intraperitoneal injection of epinephrine blocked this adrenalectomy-induced enhancement of the DBV-induced antinociceptive effect. Moreover, injection of a phenylethanolamine N-methyltransferase (PNMT) inhibitor enhanced the DBV-induced antinociceptive effect. Administration of nonselective β-adrenergic antagonists also significantly potentiated this DBV-induced antinociception, in a manner similar to adrenalectomy. These results demonstrate that the antinociceptive effect of DBV treatment can be significantly enhanced by modulation of adrenal medulla-derived epinephrine and this effect is mediated by peripheral β-adrenoceptors. Thus, DBV acupoint stimulation in combination with inhibition of peripheral β-adrenoceptors could be a potentially novel strategy for the management of inflammatory pain.

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“…All biological samples were stored at 201C until morphine determination. Morphine content was deter mined by the HPLC-ECD method as previously described (5). The half-life of morphine in the CNS and plasma dur ing 40-120 min was calculated using the individual value of morphine concentration at 120 min and the mean value of morphine concentration at 40 min.…”

Section: Methodsmentioning

confidence: 99%

Effect of Naloxone on the Morphine Concentration in the Central Nervous System and Plasma in Rats

Miyamoto¹,

Morita²,

Nakamura³

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-We investigated whether the distribution (concentration) of morphine in the central nervous system (CNS) after systemic administration could be an index for the in vivo binding of morphine. Neither the morphine concentration nor its decline correlated with the density of opiate receptors. Naloxone de creased the morphine concentration in some CNS regions and plasma after a high dose of morphine, but not after a small dose of morphine. The CNS regions in which naloxone decreased the morphine concentration did not correlate with the density of opiate receptors, and the concentration ratios (CNS regions versus plasma) of morphine were not affected by naloxone. These results suggested that the morphine concentra tion in the CNS did not reflect the in vivo binding of morphine and that the naloxone-induced decrease in morphine concentration was not due to a displacement of morphine from its receptor sites but due to a change in morphine kinetics. Pharmacokinetic studies suggested that naloxone decreased the morphine con centration through an increased volume of morphine distribution. This naloxone-induced decrease in mor phine concentration may contribute to the naloxone-induced inhibition of morphine action in addition to the competitive antagonism at opiate receptors.

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Effect of adrenalectomy on correlation of analgesia with tissue content of morphine

Cited by 13 publications

References 14 publications

Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test

Blockade of Adrenal Medulla-Derived Epinephrine Potentiates Bee Venom-Induced Antinociception in the Mouse Formalin Test: Involvement of Peripheralβ-Adrenoceptors

Effect of Naloxone on the Morphine Concentration in the Central Nervous System and Plasma in Rats

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