Effect of Adrenals, Pituitary, Liver, and Mucopolysaccharides on Blood Lipids

The Serum Cholesterol Level and Mucosal Mast Cell Count in the Gastrointestinal Tract of Rats in Dexamethasone‐shock

“…Beta-lipoproteins decrease in human blood under the influence of compound 48/80, a histamine liberator, while heparinemia increases (SICUTERI et al 1961). Lipemia and cholesterolemia increase in rats during acute stress (SEIFTER et al 1959) when the mobilised glucocorticoids possibly use the polysaccharides of the organism for their conjugation. After adrenalectomy during stress the elevation of the lipoid and cholesterol levels in rat blood is inhibited (SEIFTER et al 1959) and the degranulation of gastric mucosal mast cells also disappears under the influence of ACTH (RASANEN 1961).…”

“…Mast cells are degranulated fairly completely throughout the rat gastrointestinal tract by dexamethasone in a short time (RASANEN 1962). As stress, ACTH and glucocorticoids inactivate the serum clearing factor and at the same time raise the plasma cholesterol level (SEIFTER et al 1959) and, on the other hand, deplete the heparinoid stores of the gastrointestinal tract, we decided to ascertain the extent to which dietary cholesterol affects the serum cholesterol level in rats during dexamethasone therapy. la0 SIATTT HAIKOXEN AN11 TOIMI RASAKEN Method l l a l c rats aged 4-5 months of Ilawley-Sprague strain were usrd for the invcstigatioii.…”

Lipid Mobilization by a Crystalline Peptide Isolated from Plasma of Horses Administered Cortisone.

“…I t has been reported that administration of cortisone resulted in the appearance in the plasma of an agent that inhibits the delactescing action of plasma obtained after heparin administration ( 1 ) . This observation has been confirmed(2) and a less direct demonstration of this phenomenon has also been reported (3).…”

“…(1) The active hyperlipemia inducing constituent of the dialyzate obtained from the plasma of horses administered cortisone has been crystallized and tentatively identified as a peptide. ( 2 ) Injection of 0.02 pg of crystalline material/ kg I\: induced marked hyperlipemia in intact mice.…”

“…The sterile, pyrogen-f ree dialyzate was prepared as previously described by us (4). Preliminary chemical studies suggested that the active material was a polypeptide.…”