Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials

Liubaoerjijin, Yilina; Terada, Tasuku; Fletcher, Kevin; Boulé, Normand G.

doi:10.1007/s00592-016-0870-0

Cited by 105 publications

(91 citation statements)

References 31 publications

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“…In contrast, basal and postexercise insulin-stimulated glucose uptake appears to be impaired and contribute to the development of chronic disease (8, 44, 45). Regular exercise in both healthy and clinical populations improves indices of glycemic control including glycated hemoglobin (HbA1c) and insulin sensitivity in a “dose”-dependent manner (duration and intensity) (2, 46). It is generally conceded that training-induced improvements in glycemic control lead to improved insulin action in part through the upregulation of key skeletal muscle glucose homeostasis regulatory proteins such as Akt1/2, AS160, AMPK, hexokinase 2, and importantly GLUT4 (6, 7).…”

Section: Exercise and Glycemic Controlmentioning

confidence: 99%

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Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling

et al. 2017

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Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced. Furthermore, regular exercise leads to the upregulation of antioxidant defense, which likely assists in the mitigation of chronic oxidative stress-associated disease. In this review, we explore the complex spatiotemporal interplay between exercise, oxidative stress, and glycemic control, and highlight exercise-induced reactive oxygen species and redox-sensitive protein signaling as important regulators of glucose homeostasis.

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Section: Exercise and Glycemic Controlmentioning

confidence: 99%

“…Regular exercise can assist in the prevention and management of metabolic disease (2). Even a single session of exercise can improve glycemic control for up to 48 h postexercise (3–5).…”

Section: Introductionmentioning

confidence: 99%

Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling

et al. 2017

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“…A number of reviews have also reported a positive impact of activity monitors on people with Type 2 diabetes . The additional information displayed on accelerometers, such as exercise intensity or estimated expended calories, may enhance the effect of some behaviour change techniques (such as goal setting or feedback on performance), increasing motivation and therefore physical activity . No systematic review, however, has specifically examined the effects of accelerometer use alone, or contrasted the impact of pedometers and accelerometers on physical activity behaviour within Type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Impact of accelerometer and pedometer use on physical activity and glycaemic control in people with Type 2 diabetes: a systematic review and meta‐analysis

et al. 2017

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“…Compared to continuous moderate-intensity exercise (CMIE), high-intensity interval exercise (HIIE) has been shown to elicit comparable and/or greater improvements in glycemic control (Gibala et al, 2012; Liubaoerjijin et al, 2016). Notably, an improvement in glycemic control can be seen even after a single bout of exercise (Gillen et al, 2012; van Dijk et al, 2012; Little et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Acute Low-Volume High-Intensity Interval Exercise and Continuous Moderate-Intensity Exercise Elicit a Similar Improvement in 24-h Glycemic Control in Overweight and Obese Adults

et al. 2017

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Background: Acute exercise reduces postprandial oxidative stress and glycemia; however, the effects of exercise intensity are unclear. We investigated the effect of acute low-volume high-intensity interval-exercise (LV-HIIE) and continuous moderate-intensity exercise (CMIE) on glycemic control and oxidative stress in overweight and obese, inactive adults.Methods: Twenty-seven adults were randomly allocated to perform a single session of LV-HIIE (9 females, 5 males; age: 30 ± 1 years; BMI: 29 ± 1 kg·m−2; mean ± SEM) or CMIE (8 females, 5 males; age: 30 ± 2.0; BMI: 30 ± 2.0) 1 h after consumption of a standard breakfast. Plasma redox status, glucose and insulin were measured. Continuous glucose monitoring (CGM) was conducted during the 24-h period before (rest day) and after exercise (exercise day).Results: Plasma thiobarbituric acid reactive substances (TBARS; 29 ±13%, p < 0.01; mean percent change ±90% confidence limit), hydrogen peroxide (44 ± 16%, p < 0.01), catalase activity (50 ± 16%, p < 0.01), and superoxide dismutase activity (21 ± 6%, p < 0.01) significantly increased 1 h after breakfast (prior to exercise) compared to baseline. Exercise significantly decreased postprandial glycaemia in whole blood (−6 ± 5%, p < 0.01), irrespective of the exercise protocol. Only CMIE significantly decreased postprandial TBARS (CMIE: −33 ± 8%, p < 0.01; LV-HIIE: 11 ± 22%, p = 0.34) and hydrogen peroxide (CMIE: −25 ± 15%, p = 0.04; LV-HIIE: 7 ± 26%; p = 0.37). Acute exercise provided a similar significant improvement in 24-h average glucose levels (−5 ± 2%, p < 0.01), hyperglycemic excursions (−37 ± 60%, p < 0.01), peak glucose concentrations (−8 ± 4%, p < 0.01), and the 2-h postprandial glucose response to dinner (−9 ± 4%, p < 0.01), irrespective of the exercise protocol.Conclusion: Despite elevated postprandial oxidative stress compared to CMIE, LV-HIIE is an equally effective exercise mode for improving 24-h glycemic control in overweight and obese adults.

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Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials

Cited by 105 publications

References 31 publications

Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling

Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling

Impact of accelerometer and pedometer use on physical activity and glycaemic control in people with Type 2 diabetes: a systematic review and meta‐analysis

Acute Low-Volume High-Intensity Interval Exercise and Continuous Moderate-Intensity Exercise Elicit a Similar Improvement in 24-h Glycemic Control in Overweight and Obese Adults

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