Effect of aerobic exercise training on leptin and liver enzymes in non-diabetic overweight hepatitis C men

Abstract

Introduction: Leptin is one of the new adipokines that reflects the pathological status of liver tissue in the chronic hepatitis C virus (HCV). This study aimed to investigate the leptin and liver enzymes responses to aerobic exercise (AE) in overweight nondiabetics with HCV.Material and methods: Forty nondiabetic non-cirrhotic HCV men aged 40-60 years old with a body mass index (BMI) varied from 25-29.9 kg/m2 were divided randomly to study and control groups. The study group (n = 20) received a 3-session continuous moderate-intensity AE per week for 12 weeks while the control group (n = 20) were advised to maintain their normal level of physical activity. Pre and post measurements of weight, BMI, waist circumference, fasting blood glucose (FBG), alanine transaminase (ALT), aspartate transaminase (AST), and leptin were measured for all forty patients.Results: Statistical ANOVA analysis revealed a post-treatment significant statistical decrease of all variables within the study group (p < 0.05) while the control group showed a non-significant difference of all measurements. Post-treatment between-group analysis showed a significant statistical difference in FBG, ALT, AST, and leptin in favor of the study group.Conclusions: To restore the normal hepatic cellular functions and to prevent HCV-induced hepatic fibrosis, AE is a strong therapeutic modality that lowers leptin levels via weight maintenance and/or loss, increased glucose uptake, and declined liver enzymes.

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“…3 After that, Mahmoud A and others also mentioned this term in their respective published articles, but they are only a superficial explanation, there is no research on its definition and its composition. 4 The earliest expression of the concept of "special ability" was put forward by Rezaei S in 1999: Special ability refers to the competitive ability an athlete has in a specific special field, and it is the competitive ability that must be possessed to improve the level of special training and the performance of special sports. Therefore, it is a subordinate concept of athletic ability and a part of athletic ability.…”