Effect of age and hypoxia/reoxygenation on mRNA expression of antioxidative enzymes in rat liver and kidneys

Hypoxia-Adaptation Involves Mitochondrial Metabolic Depression and Decreased ROS Leakage

“…2E,F). Although increased ROS production and markers of oxidative stress under acute hypoxia exposure were consistently reported by many groups [25], [26], [27], including ours [8], mitochondria from the AF did not exhibit such increase relative to the NF. This indicates that adaptation to long-term hypoxia involves the amelioration of the initial burst of oxidative insult triggered by limited oxygen availability in the parent generation.…”

Molecular cloning and expression analysis of a thioredoxin from rock bream, Oplegnathus fasciatus, and biological activity of the recombinant protein

“…Additionally, gills express high amounts of antioxidant proteins such as cytosolic Mn superoxide dismutase [34] and catalase [35] and detoxifying enzymes such as glutathione-Stransferase (GST) [36]. Furthermore, liver and kidney are the main metabolic centres for ROS production [37]. In fish, there are currently no published reports on the tissue-specific expression of TRx1; however, in Scophthalmus maximus the expression of perioredoxin was most abundant in head kidney, liver, intestine, and skin but sometimes undetectable in spleen [38].…”

Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress

“…The reason for these changes as the rats aged was not understood. Alteration in antioxidant enzymes had been demonstrated during aging and such changes varied with different tissues (Campisi et al, 1999;Gumuslu et al, 2001;Jang et al, 2001;Martin et al, 2002). One recent report showed that gene expression of Cu/Zn SOD, glutathione reductase and GPX in the kidneys was significantly higher in old Wistar rats as compared to young rats (Martin et al, 2002).…”