Effect of Age, Gender, Blood Group and Social State on the Sero-Prevalence of Helicobacter Pylori Infection Among Asymptomatic Subjects in Sulaimani

Ibrahim, Hossam; Al-Dhahir, Hawa A. R.; Mohammed, Mohammed Omer

doi:10.17656/jsmc.10066

JSMC

2015

DOI: 10.17656/jsmc.10066

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Effect of Age, Gender, Blood Group and Social State on the Sero-Prevalence of Helicobacter Pylori Infection Among Asymptomatic Subjects in Sulaimani

Hossam Ibrahim¹,

Hawa A. R. Al-Dhahir²,

Mohammed Omer Mohammed³

Abstract: Background It is known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. Infections due to H. pylori are most widespread among the developing regions due to poor standard of public health. Objectives This study sought to determine the seroprevalence of H. pylori in asymptomatic individual in Sulaimani and to correlate such prevalence with age, gender, blood group and Socioeconomic state. Methods This study conducted in Ali Kamal Consul… Show more

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Cited by 2 publications

References 27 publications

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Comparison Among Different Laboratory Tests for the Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients in Sulaimani Governorate

Khorshid¹,

Omer²,

Abdulla³

2017

JSMC

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Background Helicobacter pylori is a helical Gram-negative bacterium that colonizes human gastric mucosa leading to various pathologies including gastritis, gastric ulcers and gastric adenocarcinoma. Colonization is worldwide and affecting all age groups. Objectives To identify H. pylori colonization among patients with dyspepsia using different laboratory tests including serology, stool antigen and PCR, and comparing the sensitivity and specificity of these tests. Materials and Methods From June through December 2014, one hundred patients with dyspepsia were enrolled in this study. They were 64 females (mean age 40.2 y) and 36 males (mean age 42.1 y). Two gastric antral biopsy specimens were taken in all patients submitted to esophagogastroduodenoscopy. Blood and stool specimens were also obtained from each patient. Four diagnostic laboratory tests were used for detection of the infection. Blood samples were tested for antibodies using rapid immunochromatography assay, stool for H. pylori antigen with immunochromatographic method and lastly PCR amplification of glmM gene was used to detect the organism in both gastric tissue and stool samples. Results Esophagogastroduodenoscopy revealed that the majority of patients had gastritis and or duodenitis. Stool PCR for H. pylori was positive in 42% of the patients. Anti-H. pylori IgG in the blood and bacterial antigen were detected in 72% and 74% of patients respectively, while PCR test on gastric biopsy specimens was positive in 82% of the samples. Conclusion H. pylori infection was detected regardless of the presence or absence of visible gastroduodenal pathology. PCR examination of gastric tissue was better than stool samples. In comparison to gastric biopsy PCR, stool antigen detection was found to be the most sensitive test reaching 87.8% while stool PCR was the most specific test. No single test solely can be used to diagnose or exclude colonization.

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Comparison Among Different Laboratory Tests for the Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients in Sulaimani Governorate

Khorshid¹,

Omer²,

Abdulla³

2017

JSMC

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The Evaluation of Triple, Quadruple, and Levofloxacin-Based Therapy in the Management of Helicobacter Pylori Infection Among Dyspeptic Patients

Mohammed¹,

Arif²,

Mohammed³

2019

JSMC

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Background The eradication rate for the first line therapy in H. pylori infection declined worldwide as a result of resistance development; however other therapies as quadruple and levofloxacin-based therapy are also used and have different eradication rate. Objectives To assess the response rate of H. pylori infection for different drug’s regimens (triple, quadruple, and levobased), and evaluate the effect of age, gender, body mass index and compliance of the patients on the regimens response rate. Methods A cross- sectional study, conducted in Kurdistan Center for Gastroenterology and Hepatology (KCGH) in Sulaimani, from April 2018 –November 2018. The study Included 753 dyspeptic patients, H. pylori were positive in 430 (57.1%) patients. Demographic data, anthropometric measures, and clinical presentations were recorded for the participants. The participants were randomly treated with one of the standard H. pylori eradication regimens (triple, quadruple or levobased), they have been followed up for 45 days and rechecked for H. pylori. Results The mean age of the patients was 39.8± 15.6 years, and the mean Body Mass Index was 25.7± 6.1kg/m2, 182(42.3%) were male and 248 (57.7%) were female. The rates of responses were (84.4%, 89.4%, and 97.4%) for the triple, quadruple and levobased regimens respectively. The most adverse effects were dizziness and metallic taste recorded in 30.3% in the quadruple group. Statistically, a significant difference was found in the response rate among the triple, quadruple and levobased regimens (p= 0.033). There were no significant differences in the response rate among the three regimens group regarding age, gender, and body mass index. More than 95% in those who completed follow up were adherent to their regimens. Conclusion Triple and quadruple regimens are still effective for H. pylori eradication, but have more adverse effects than levobased regimens. Levobased regimen has highest eradication rate for H. pylori, better compliance, and least adverse effects.

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Effect of Age, Gender, Blood Group and Social State on the Sero-Prevalence of Helicobacter Pylori Infection Among Asymptomatic Subjects in Sulaimani

Cited by 2 publications

References 27 publications

Comparison Among Different Laboratory Tests for the Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients in Sulaimani Governorate

Comparison Among Different Laboratory Tests for the Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients in Sulaimani Governorate

The Evaluation of Triple, Quadruple, and Levofloxacin-Based Therapy in the Management of Helicobacter Pylori Infection Among Dyspeptic Patients

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