Background It is known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. Infections due to H. pylori are most widespread among the developing regions due to poor standard of public health. Objectives This study sought to determine the seroprevalence of H. pylori in asymptomatic individual in Sulaimani and to correlate such prevalence with age, gender, blood group and Socioeconomic state. Methods This study conducted in Ali Kamal Consultation clinic, Kurdistan Teaching center of Gastroenterology & Hepatology (escorts of patients) and students from University of Sulaimani, from the 1st of January to the 20th of November 2013. Serum samples from 188 apparently healthy subjects were tested for the presence of IgG and IgA antibody to H. pylori by use of ELISA test. ABO blood grouping was also done by hemagglutination test. Results Of the 188 subjects, there were 92(48.9%) males and 96 (51.1%) females. The age range was 20 to 49 years. The overall prevalence of H. pylori infection in our study was 68.1%. H. pylori antibodies were positive in 73(79.4%) males and 55(57.3%) females, showing no significant difference P=0.079. The overall seroprevalence was found in 57.1% subjects between 20-29 years of age, 75.8% in subjects between 40-49 years of age showing significant difference P=0.045. Distribution of ABO blood groups in H. pylori positive group were, A=70.2%, B=32.4%, AB=57.1% and O=86.1%, with a statistically significant link for blood group O (p=0.001). H. pylori sero-positivity was higher in low social state 59(93.7%), moderate social state 47(87%) then lowest in high social state 22 (31%), P = 0.032. Conclusions This study demonstrated that H. pylori infection can be related to ABO blood group, age and social state. People of blood group O, 40-49 years of age and low social state are more prone to develop this infection.