Effect of age on axoplasmic transport of cholinesterase in rat sciatic nerves

McMartin, Donald N.; O'Connor, James A.

doi:10.1016/0047-6374(79)90038-1

Cited by 66 publications

(18 citation statements)

References 28 publications

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“…The reduction in transport was not due to a reduction in axon number as determined by histological evaluation of axon numbers. Interestingly, the reduction in transport appeared to correlate with the extent of muscle atrophy seen in these rats (Gutmann and Hanzlikova, 1973; McMartin and O’Connor, 1979). …”

Section: Age-related Changes In Neuromuscular Systemmentioning

confidence: 88%

Age-associated alterations of the neuromuscular junction

Jang

Remmen

2011

Experimental Gerontology

212

192

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Age-related loss of muscle mass and function greatly affects quality of life in the elderly population. Several hypotheses have been proposed but accumulating evidence point to alterations in neuromuscular system during aging as a key event that leads to functional denervation, muscle wasting, and weakness. Over the past few decades, age-associated degeneration of the neuromuscular junction (NMJ) and its components have been well documented. With advancing age, pre-terminal portions of motor axons exhibit regions of abnormal thinning, distension, and sprouting whereas postsynaptic endplates decrease in size, reduce in number, length, and density of postsynaptic folds. Although the exact underlying mechanisms are still lacking, recent studies provided direct evidence that age-associated increase in oxidative stress plays a crucial role in NMJ degeneration and progression of sarcopenia. Homozygous deletion of an important antioxidant enzyme, Cu,Zn superoxide dismutase (CuZnSOD, SOD1) leads to acceleration of agedependent muscle atrophy, with a significant NMJ degeneration similar to that seen in old wild type sarcopenic animals. In this short review, we briefly summarize the current understanding of some of the cellular and molecular changes in the NMJ during aging and suggest a role for oxidative stress and mitochondrial dysfunction in age-related changes in the maintenance of neuromuscular innervation.

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Section: Age-related Changes In Neuromuscular Systemmentioning

confidence: 88%

Age-associated alterations of the neuromuscular junction

Jang

Remmen

2011

Experimental Gerontology

212

192

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“…Axonal atrophy and loss of large fibers is also reported to be associated with aging (26,27). Reduction in the rate of axonal transport of various materials occurs with increasing age, and the reduced transport of microtubule and neurofilament proteins could lead to difficulties in maintaining the cytoskeletal framework, thereby leading to axonal atrophy or fiber loss (28,29). One hypothesis for the selective vulnerability of motor neurons in ALS is a high content of neurofilament proteins and large calibers of axons.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice

Andersson

Gustafsson

Warner

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

154

107

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Male mice with inactivated liver X receptor (LXR) β suffer from adult-onset motor neuron degeneration. By 7 months of age, motor coordination is impaired, and this condition is associated with lipid accumulation and loss of motor neurons in the spinal cord, together with axonal atrophy and astrogliosis. Several of these features are reminiscent of the neuropathological signs of chronic motor neuron disease such as amyotrophic lateral sclerosis. Because the LXRs are important for cholesterol and lipid metabolism, we speculate that absence of LXRβ leads to pathological accumulation of sterols and lipids that may themselves be neurotoxic or may modulate intracellular pathways and thereby predispose motor neurons to degeneration.

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“…Increased long-term neuromuscular activity may increase the uptake of trophic substances (20), which, when limited, are known to cause cell death (29). Thus, the up-regulation of neurotrophic factors and sensitivity (receptors) of the MN via increased neuromuscular activity may explain the "localized" effect of exercise on MU survival.…”

Section: Strength Voluntary Activation and Twitch Pro-mentioning

confidence: 99%

Motor Unit Survival in Lifelong Runners Is Muscle Dependent

Power

Dalton

Behm

et al. 2012

Medicine &Amp; Science in Sports &Amp; Exercise

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Although there were no significant differences in MUNE between both older groups in the biceps brachii muscle, with the number of subjects tested here, we cannot eliminate the possibility of some whole-body neuroprotective effect. However, when compared with the remote biceps muscle, a greater influence on age-related spinal motoneuron survival was found in a chronically activated MN pool specific to the exercised muscle.

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Effect of age on axoplasmic transport of cholinesterase in rat sciatic nerves

Cited by 66 publications

References 28 publications

Age-associated alterations of the neuromuscular junction

Age-associated alterations of the neuromuscular junction

Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice

Motor Unit Survival in Lifelong Runners Is Muscle Dependent

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