Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Tevald, Michael A.; Foulis, Stephen A.; Kent, Jane A.

doi:10.1007/s11357-014-9713-5

Cited by 18 publications

(19 citation statements)

References 74 publications

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“…In comparison to the current study in which we examined the thigh muscles, Kent‐Braun and Ng observed no differences in PCr levels in the tibialis anterior (TA) muscle between young and older participants (Kent‐Braun & Ng, 2000). However, in contrast to previous work (McCully et al, 1991), in vivo oxidative capacity was higher in the TA of older adults in comparison to younger counterparts despite lower physical function and minutes of moderate‐to‐vigorous physical activity (Tevald, Foulis, & Kent, 2014). This would suggest additional factors (i.e., gait biomechanics) may influence the resting metabolic profile in muscle with age.…”

Section: Discussioncontrasting

confidence: 96%

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

et al. 2020

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The loss of skeletal muscle mass and function with age (sarcopenia) is a critical healthcare challenge for older adults. 31‐phosphorus magnetic resonance spectroscopy (31P‐MRS) is a powerful tool used to evaluate phosphorus metabolite levels in muscle. Here, we sought to determine which phosphorus metabolites were linked with reduced muscle mass and function in older adults. This investigation was conducted across two separate studies. Resting phosphorus metabolites in skeletal muscle were examined by 31P‐MRS. In the first study, fifty‐five older adults with obesity were enrolled and we found that resting phosphocreatine (PCr) was positively associated with muscle volume and knee extensor peak power, while a phosphodiester peak (PDE2) was negatively related to these variables. In the second study, we examined well‐phenotyped older adults that were classified as nonsarcopenic or sarcopenic based on sex‐specific criteria described by the European Working Group on Sarcopenia in Older People. PCr content was lower in muscle from older adults with sarcopenia compared to controls, while PDE2 was elevated. Percutaneous biopsy specimens of the vastus lateralis were obtained for metabolomic and lipidomic analyses. Lower PCr was related to higher muscle creatine. PDE2 was associated with glycerol‐phosphoethanolamine levels, a putative marker of phospholipid membrane damage. Lipidomic analyses revealed that the major phospholipids, (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol) were elevated in sarcopenic muscle and were inversely related to muscle volume and peak power. These data suggest phosphorus metabolites and phospholipids are associated with the loss of skeletal muscle mass and function in older adults.

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Section: Discussioncontrasting

confidence: 96%

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

et al. 2020

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“…; Tevald et al. ), and instead suggest that muscle oxidative function is far more dependent on the muscle group studied (Kent‐Braun and Ng ; Lanza et al. , ; Larsen et al.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience

et al. 2018

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Age is the greatest risk factor for chronic disease and is associated with a marked decline in functional capacity and quality of life. A key factor contributing to loss of function in older adults is the decline in skeletal muscle function. While the exact mechanism(s) remains incompletely understood, age‐related mitochondrial dysfunction is thought to play a major role. To explore this question further, we studied 15 independently living seniors (age: 72 ± 5 years; m/f: 4/11; BMI: 27.6 ± 5.9) and 17 young volunteers (age: 25 ± 4 years; m/f: 8/9; BMI: 24.0 ± 3.3). Skeletal muscle oxidative function was measured in forearm muscle from the recovery kinetics of muscle oxygen consumption using near‐infrared spectroscopy (NIRS). Muscle oxygen consumption was calculated as the slope of change in hemoglobin saturation during a series of rapid, supra‐systolic arterial cuff occlusions following a brief bout of exercise. Aging was associated with a significant prolongation of the time constant of oxidative recovery following exercise (51.8 ± 5.4 sec vs. 37.1 ± 2.1 sec, P = 0.04, old vs. young, respectively). This finding suggests an overall reduction in mitochondrial function with age in nonlocomotor skeletal muscle. That these data were obtained using NIRS holds great promise in gerontology for quantitative assessment of skeletal muscle oxidative function at the bed side or clinic.

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“…CO 2 is approximately 20-times more diffusible than O 2 in biological tissues, and high-capillary CO 2 concentration may facilitate capillary oxyhaemoglobin unloading. Slowed kinetics of oxidative metabolism in the elderly require greater phosphocreatine breakdown for a given power output, and ensuing transient intramuscular alkalosis contributes to temporally slowing kinetics of CO 2 output relative to its production [44,49,71,72]. This, together with intra-and extra-muscular CO 2 buffers, slows muscular CO 2 production (V′CO 2 ) kinetics compared with those of V′O 2 , and therefore may lessen ventilatory demands for CO 2 clearance.…”

Section: Gas Transport Between Muscle Capillary and Mitochondriamentioning

confidence: 99%

Exercise, ageing and the lung

2016

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This review provides a pulmonary-focused description of the age-associated changes in the integrative physiology of exercise, including how declining lung function plays a role in promoting multimorbidity in the elderly through limitation of physical function. We outline the ageing of physiological systems supporting endurance activity: 1) coupling of muscle metabolism to mechanical power output; 2) gas transport between muscle capillary and mitochondria; 3) matching of muscle blood flow to its requirement; 4) oxygen and carbon dioxide carrying capacity of the blood; 5) cardiac output; 6) pulmonary vascular function; 7) pulmonary oxygen transport; 8) control of ventilation; and 9) pulmonary mechanics and respiratory muscle function. Deterioration in function occurs in many of these systems in healthy ageing. Between the ages of 25 and 80 years pulmonary function and aerobic capacity each decline by ∼40%. While the predominant factor limiting exercise in the elderly likely resides within the function of the muscles of ambulation, muscle function is (at least partially) rescued by exercise training. The age-associated decline in pulmonary function, however, is not recovered by training. Thus, loss in pulmonary function may lead to ventilatory limitation in exercise in the active elderly, limiting the ability to accrue the health benefits of physical activity into senescence.

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Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Cited by 18 publications

References 74 publications

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience

Exercise, ageing and the lung

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