Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men

Landolt, Hans‐Peter; Dijk, Derk‐Jan; Achermann, Peter; Borbély, Alexander A.

doi:10.1016/s0006-8993(96)00770-6

Cited by 308 publications

(234 citation statements)

References 26 publications

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“…They typically displayed a low sleep efficiency, which was not due to abnormal sleep onset latencies, but due to a high amount of intermittent wakefulness, particularly during the second part of the night. Although considerable for their age, the amount of slow wave sleep is lower than that usually observed in young subjects (eg Dijk et al, 1989;Landolt et al, 1996;Mathias et al, 2001). The age-related reduction in slow wave sleep is reportedly associated with a decrease in the amplitude (Feinberg et al, 1967) and number (Ehlers and Kupfer, 1989) of slow waves and, consequently, with an attenuation of spectral power density in the delta frequencies (Dijk et al, 1989;Ehlers and Kupfer, 1989;Landolt et al, 1996).…”

Section: Discussionmentioning

confidence: 77%

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Mathias

Zihl

Steiger

et al. 2004

Neuropsychopharmacol

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Aging is associated with dramatic reductions in sleep continuity and sleep intensity. Since gaboxadol, a selective GABA A receptor agonist, has been demonstrated to improve sleep consolidation and promote deep sleep, it may be an effective hypnotic, particularly for elderly patients with insomnia. In the present study, we investigated the effects of subchronic gaboxadol administration on nocturnal sleep and its residual effects during the next days in elderly subjects. This was a randomized, double-blind, placebo-controlled, balanced crossover study in 10 healthy elderly subjects without sleep complaints. The subjects were administered either placebo or 15 mg gaboxadol hydrochloride at bedtime on three consecutive nights. Sleep was recorded during each night from 2300 to 0700 h and tests assessing attention (target detection, stroop test) and memory function (visual form recognition, immediate word recall, digit span) were applied at 0900, 1400, and 1700 h during the following days. Compared with placebo, gaboxadol significantly shortened subjective sleep onset latency and increased self-rated sleep intensity and quality. Polysomnographic recordings showed that it significantly decreased the number of awakenings, the amount of intermittent wakefulness, and stage 1, and increased slow wave sleep and stage 2. These effects were stable over the three nights. None of the subjects reported side effects. Next-day cognitive performance was not affected by gaboxadol. Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects.

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Section: Discussionmentioning

confidence: 77%

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Mathias

Zihl

Steiger

et al. 2004

Neuropsychopharmacol

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“…The change in the sigma frequency in male subjects occurred regardless of the type of medication. It is important to note that two principally different types of spindles exist, those with a frequency of about 11-13 Hz and those with a frequency of about 14-16 Hz (Aeschbach et al, 1994;Tagaya et al, 2000;Landolt et al, 1996). Gender differences in the EEG spectrum of non-REM sleep exist in young healthy subjects (Dijk et al, 1989;Antonijevic et al, 1999a) and in patients with depression (Antonijevic et al, 2000b).…”

Section: Discussionmentioning

confidence: 99%

State Markers of Depression in Sleep EEG: Dependency on Drug and Gender in Patients Treated with Tianeptine or Paroxetine

Murck

Nickel

Künzel

et al. 2003

Neuropsychopharmacol

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Tianeptine enhances while paroxetine inhibits serotonin reuptake into neurons; however, both show an antidepressive action. A subgroup of 38 depressed patients from a drug trial comparing the efficacy of tianeptine with that of paroxetine was studied with regard to their effects on sleep regulation, especially in relation to treatment response. We recorded sleep EEGs at day 7 and day 42 after the start of treatment with either compound, which allows measurement of changes due to the antidepressive medication in relation to the duration of treatment. Spectral analysis of the non-REM sleep EEG revealed a strong decline in the higher sigma frequency range (14-16 Hz) in male treatment responders independent of medication, whereas nonresponders did not show marked changes in this frequency range independent of gender. The patients receiving paroxetine showed less REM sleep and more intermittent wakefulness compared to the patients receiving tianeptine. REM density after 1 week of treatment was a predictor of treatment response in the whole sample. Psychopathological features with regard to the score in single items of the HAMD revealed predictive markers for response, some of which were opposite in the gender groups, especially those related to somatic anxiety. Changes in REM density were inversely correlated to the changes in HAMD in the paroxetine, but not the tianeptine, group. Our data suggest the importance of taking gender into account in the study of the biological effects of drugs. The study further points to the importance of the higher sigma frequency range in the sleep EEG of non-REM sleep and REM density as a marker of treatment response.

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“…The decline in sleep consolidation, together with the advance of sleep timing, may reflect age-related changes in the homeostatic and/or circadian aspects of sleep regulation (Cajochen et al, 2006;Dijk et al, 1999). From the sleep homeostatic perspective, older people display a shallower dissipation of sleep pressure, as indexed by reduced SWS and slow wave activity (SWA) (electroencephalographic [EEG] power density between 0.75 and 4.5 Hz, also referred to as delta activity) dynamics across the night (Dijk and Beersma, 1989;Landolt et al, 1996). From a circadian standpoint, aging can be associated with a reduced circadian amplitude of the core body temperature (CBT) rhythm, and a phase advance of the CBT and melatonin rhythm .…”

Section: Introductionmentioning

confidence: 99%

Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

Viola

Chellappa

Archer

et al. 2012

Neurobiology of Aging

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Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeostatic sleep regulation in young volunteers are associated with the variable-number, tandem-repeat (VNTR) polymorphism (rs57875989) in the coding region of the circadian clock gene PERIOD3 (PER3). However, predictors of these interindividual differences have yet to be identified in older people. Sleep electroencephalographic (EEG) characteristics and circadian rhythms were assessed in 26 healthy older volunteers (55-75 years) selected on the basis of homozygosity for either the long or short allele of the PER3 polymorphism. Homozygosity for the longer allele (PER3 5/5 ) associated with a phase-advance in the circadian melatonin profile and an earlier occurrence of the melatonin peak within the sleep episode. Furthermore, older PER3 5/5 participants accumulated more nocturnal wakefulness, had increased EEG frontal delta activity (0.75-1.50 Hz), and decreased EEG frontal sigma activity (11-13 Hz) during non-rapid eye movement (REM) sleep compared with PER3 4/4 participants. Our results indicate that the polymorphism in the clock gene PER3 may contribute to interindividual differences in sleep and circadian physiology in older people.

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Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men

Cited by 308 publications

References 26 publications

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

State Markers of Depression in Sleep EEG: Dependency on Drug and Gender in Patients Treated with Tianeptine or Paroxetine

Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

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