Effect of age on the repertoire of cytotoxic memory (CD8+CD45RO+) T cells in peripheral blood: The use of rearranged T cell receptor γ genes as clonal markers

Dare, Raellene; Sykes, Pamela J.; Morley, Alexander A.; Brisco, Michael J.

doi:10.1016/j.jim.2005.08.016

Cited by 3 publications

(1 citation statement)

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“…Our results confirm that the normal process of aging results in impaired thymopoiesis (Figure 1) that may predispose to infections and cancers (20)(21)(22)(23). Moreover, aging-associated impairments in thymopoiesis, and/or thymic reserve, appear to influence thymic response to Nelfinavir therapy ( Figure 2).…”

Section: Discussionsupporting

confidence: 81%

Nelfinavir monotherapy increases naive T-cell numbers in HIV-negative healthy young adults

Vlahakis¹

2008

Front Biosci

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Although patients treated with HIV protease inhibitor (PI) containing regimens manifest increases in naïve T cell number, it is unclear whether this is due to reduction in viral replication or a direct drug effect. We questioned whether Nelfinavir monotherapy directly impacted naïve T-cell number in HIV-negative individuals. HIV-negative volunteers received Nelfinavir, 1250 mg orally, BID for 3 weeks, and T-cell receptor recombination excision circles (TREC) content in peripheral blood were assessed. Whereas TREC copies did not change over 3 weeks in untreated controls, TREC copies/copies CCR5 increased following Nelfinavir monotherapy in 8 patients (p < 0.02), and did not change in 7 patients (p = NS). Those patients who responded were younger than those who did not with a median age of 55 years for responders and 71 years for non-responders (p < 0.03). The increase in TREC was most pronounced in those patients less than 40-years old (p < 0.01). Moreover, the patients who did not increase TREC levels were more likely to have suffered a medical illness previously shown to reduce thymic function. In HIV-negative patients, monotherapy with the HIV PI Nelfinavir for 21 days increases TREC-positive naïve T cell number, particularly in individuals who are healthy and young.

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Section: Discussionsupporting

confidence: 81%