Effect of ageing and oxidative stress on antioxidant enzyme activity in different regions of the rat kidney

Thiab, Noor Riyadh; King, Nicola; Jones, Graham P.

doi:10.1007/s11010-015-2503-2

Cited by 10 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible to speculate that one possible explanation for this redistribution could be changes in the demand for amino acids for glutathione synthesis. This is supported by independent studies which reported: (1) a decreased level of glutathione accompanied with increased activity and protein levels of glutathione synthetase with ageing (Thiab et al, 2015), and (2) a significant decrease in the reabsorption of Cys-Gly, a break-down product of GSH, in PEPT2-deficient animals (Rubio-Aliaga et al, 2003;Frey et al, 2006;Frey et al, 2007).…”

Section: Discussionmentioning

confidence: 71%

Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule

Alghamdi

King

Andronicos³

et al. 2022

Amino Acids

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 71%

Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule

Alghamdi

King

Andronicos³

et al. 2022

Amino Acids

Self Cite

View full text Add to dashboard Cite

show abstract

“…Correspondingly, the activity of antioxidant enzymes was evaluated here to provide an indirect measure of oxidative stress. 3,64 We assessed the in vivo levels of antioxidant enzymes (T-SOD, GSH-Px, and CAT), and the capacity of MDA and T-AOC, in bone. Our data demonstrate that puerarin alleviates oxidative stress induced by cadmium in bone tissue.…”

Section: Discussionmentioning

confidence: 99%

Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats

Tong

Guo

Liu

et al. 2021

Environmental Toxicology

View full text Add to dashboard Cite

Autophagy is a regulatory mechanism involved in cadmium (Cd)-induced bone toxicity and is suppressed by various stimuli, including oxidative stress. Puerarin is an isoflavonoid compound isolated from Pueraria, a plant used in traditional Chinese medicine. The underlying mechanisms of action of puerarin remain unclear. The objective of this study was to explore the mitigating effects of puerarin on cadmiuminduced oxidative damage in the bones of rats. Cadmium exposure increased oxidative damage in rat bones; this was markedly decreased by puerarin treatment, as demonstrated by changes in the activity of antioxidative enzymes. Cadmium-induced blockage of the expression of key bone regulatory proteins, autophagy-related markers, and signaling molecules was also alleviated by puerarin treatment. Additionally, cadmium reduced expression of the autophagic protein Rab7 and of late endosomal/lysosomal adaptor and MAPK and mTOR activator 1 (LAMTOR1); the decrease in these proteins was not restored by puerarin treatment. We speculate that puerarin relieves the inhibition of fusion of autophagosomes with lysosomes that is induced by cadmium; however, this specific effect of puerarin and downstream effects on bone regulatory mechanisms require further investigation. In conclusion, puerarin alleviates cadmium-induced oxidative damage in the bones of rats by attenuating autophagy, which is likely associated with the antioxidant activity of puerarin.

show abstract

“…The aging process can affect kidney health, including loss of kidney parenchymal volume, glomerular sclerosis, and tubular atrophy, resulting in a decline in kidney function [1]. During the aging process, there is an accumulation of reactive oxygen species and a reduction in antioxidant capacity, which may lead to increased oxidative stress levels and result in kidney damage [2][3][4][5]. Furthermore, an increase in iron accumulation is another change that occurs with aging [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Lifelong Aerobic Exercise on Ferroptosis-Related Gene Expressions in Kidney of Aged Mice

Xiang,

Baek,

Won

et al. 2023

Exerc Sci

View full text Add to dashboard Cite

PURPOSE: This study sought to explore the impact of continuous aerobic exercise throughout life on the expression of ferroptosis-related genes in aging kidneys, elucidating the role of exercise in maintaining kidney health.METHODS: Male C57BL/6 mice were divided into young control, young exercise, old control, and old exercise groups, with the latter providing access to spontaneous running wheels. Aged mice were observed until 99 weeks, while young mice were followed until 22 weeks. Kidney tissue samples underwent analysis through quantitative polymerase chain reaction, iron assays, histological staining, and pathological damage scoring.RESULTS: Expression of Nphs1 and Nphs2 exhibited no significant changes after exercise. However, histological analysis revealed that age-related kidney damage, including glomerular mesangial proliferation, was notably offset by lifelong aerobic exercise. The expression of Slc7a11 and Gpx4 remained unaffected by exercise, whereas Nfe2l2 expression decreased significantly in the young exercise groups. Acsl4 expression exhibited no aging- or exercise-induced differences. Additionally, Tfrc expression was lower in the young exercise group than in the young control group but remained consistent between the old and old-exercise groups. Total iron (Fe) increased in aged mice compared to that in the young-exercise group, and the Fe2+/Total Fe ratio was lower in the old-exercise than in the old control group.CONCLUSIONS: Lifelong aerobic exercise positively impacted kidney health by enhancing antioxidant capacity and mitigating iron accumulation. These findings underscore the significance of exercise in preventing age-related deterioration in kidney function.

show abstract

Effect of ageing and oxidative stress on antioxidant enzyme activity in different regions of the rat kidney

Cited by 10 publications

References 48 publications

Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule

Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule

Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats

Effects of Lifelong Aerobic Exercise on Ferroptosis-Related Gene Expressions in Kidney of Aged Mice

Contact Info

Product

Resources

About