Effect of Ageing on Colonic Endocrine Cell Population in Mouse

Sandström, Olof; Mahdavi, Jafar

doi:10.1159/000022036

Cited by 19 publications

(10 citation statements)

References 19 publications

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“…In the present study, glucagon‐IR cells were restricted to the fundus with rare frequency. These findings were quite different from those of previous studies ( Kitamura et al., 1990; Agungpiryono et al., 1994; Sandstrom et al., 1998; Spangeus and El‐Salhy, 1998; Yamada et al., 1999), but similar to those of Lee et al. (1991).…”

Section: Discussioncontrasting

confidence: 99%

“…Collectively it is considered that the distributional patterns of glucagon‐IR cells in the GI tract of mammals show species‐dependent variation. In particular, the appearance of these IR cells in large intestine was also reported in mouse ( Sandstrom et al., 1998; Spangeus and El‐Salhy, 1998). In the present study, glucagon‐IR cells were restricted to the fundus with rare frequency.…”

Section: Discussionsupporting

confidence: 63%

“…Abnormalities of small intestinal ( El‐Salhy et al., 1998) and antral ( El‐Salhy and Spangeus, 1998) endocrine cells in non‐obese diabetic mice were also reported compared to normal BALB/cJ mouse. In addition, changes in mice of regional distribution and relative frequency of some GI endocrine cells with ageing were reported ( Sandstrom et al., 1998, 1999; Sandstrom and El‐Salhy, 2000).…”

Section: Introductionmentioning

confidence: 99%

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The Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in SHK‐1 Hairless Mice: An Immunohistochemical Study

Lee

et al. 2002

Anat Histol Embryol

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The regional distributions and relative frequencies of some gastrointestinal endocrine cells in the eight portions (fundus, pylorus, duodenum, jejunum, ileum, caecum, colon and rectum) of the gastrointestinal tract of SKH-1 hairless mice were investigated using immunohistochemical methods and seven types of specific antisera against somatostatin, serotonin, glucagon, cholecystokinin (CCK)-8, secretin, pancreatic polypeptide (PP) and gastrin. In this study, somatostatin-, serotonin-, glucagon-, CCK-8-, secretin- and gastrin-immunoreactive (IR) cells were identified. Most of these IR cells in the intestinal portion were generally spherical or spindle-shaped (open-type cell) while cells that were round in shape (close-type cell) were occasionally found in the stomach regions. Their relative frequencies were varied according to each portion of gastrointestinal tract. Somatostatin-IR cells were found throughout the gastrointestinal tract except for the large intestine. Serotonin-IR cells were detected throughout the whole gastrointestinal tract and were the most predominant endocrine cell types in this species of mouse. Glucagon-IR cells were restricted to the fundus, occurring rarely. CCK-8-IR cells were observed in the pylorus, duodenum and jejunum with frequencies that were numerous, moderate and few, respectively. Peculiarly, secretin-IR cells were demonstrated in the whole intestinal tract with either few or rare frequencies. Gastrin-IR cells were restricted to the pylorus and were numerous. However, no PP-IR cells were found in this study. In conclusion, some peculiar distributional patterns of gastrointestinal endocrine cells were found in SKH-1 hairless mouse.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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The Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in SHK‐1 Hairless Mice: An Immunohistochemical Study

Lee

et al. 2002

Anat Histol Embryol

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“…Increases in the numbers of some types of enteroendocrine cells in aging mouse colon (Sandstrom et al 1998) and human duodenum (Sandstrom and El-Salhy 1999a) have been described. In the mouse duodenum, increases in some populations but decreases in others have been reported (Sandstrom and El-Salhy 2000), while no changes were reported in human rectum by the same authors (Sandstrom and El-Salhy 1999b).…”

Section: Aging Of the Intestinal Mucosamentioning

confidence: 99%

Aging of the mammalian gastrointestinal tract: a complex organ system

Saffrey

2013

AGE

122

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Gastrointestinal disorders are a major cause of morbidity in the elderly population. The gastrointestinal tract is the most complex organ system; its diverse cells perform a range of functions essential to life, not only secretion, digestion, absorption and excretion, but also, very importantly, defence. The gastrointestinal tract acts not only as a barrier to harmful materials and pathogens but also contains the vast number of beneficial bacterial populations that make up the microbiota. Communication between the cells of the gastrointestinal tract and the central nervous and endocrine systems modifies behaviour; the organisms of the microbiota also contribute to this brain–gut–enteric microbiota axis. Age-related physiological changes in the gut are not only common, but also variable, and likely to be influenced by external factors as well as intrinsic aging of the cells involved. The cellular and molecular changes exhibited by the aging gut cells also vary. Aging intestinal smooth muscle cells exhibit a number of changes in the signalling pathways that regulate contraction. There is some evidence for age-associated degeneration of neurons and glia of the enteric nervous system, although enteric neuronal losses are likely not to be nearly as extensive as previously believed. Aging enteric neurons have been shown to exhibit a senescence-associated phenotype. Epithelial stem cells exhibit increased mitochondrial mutation in aging that affects their progeny in the mucosal epithelium. Changes to the microbiota and intestinal immune system during aging are likely to contribute to wider aging of the organism and are increasingly important areas of analysis. How changes of the different cell types of the gut during aging affect the numerous cellular interactions that are essential for normal gut functions will be important areas for future aging research.

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“…(1995) showed that gastrointestinal endocrine cells in genetically diabetic (db/db) mouse had quite different distributional patterns compared with non‐diabetic control (db/+) mouse. In addition, the changes of regional distribution and relative frequency of some gastrointestinal endocrine cells in mice with ageing were also reported (Sandstrom et al., 1998, 1999; Sandstrom and El‐Salhy, 2000). Ku et al.…”

Section: Introductionmentioning

confidence: 96%

An Immunohistochemical Study of Gastrointestinal Endocrine Cells in the BALB/c Mouse

Lee

2004

Anat Histol Embryol

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The distributions and frequencies of some endocrine cells in the eight portions of the gastrointestinal tract (GIT) of BALB/c mouse were studied. Endocrine cells were stained using immunohistochemical method with seven types of antisera against bovine chromogranin (BCG), serotonin, gastrin, cholecystokinin (CCK)-8, somatostatin, glucagon and human pancreatic polypeptide (HPP), and the regional distributions and their relative frequencies were observed in the eight portions of the GIT of BALB/c mice. All seven types of immunoreactive (IR) cells were identified. Most of the IR cells in the intestinal portion were generally spherical or spindle in shape (open type cell) while round-shaped cells (closed type cell) were found in the intestinal gland and stomach regions occasionally. Their relative frequencies varied according to each portion of the GIT. BCG-IR cells were observed throughout the whole GIT except for the rectum and they were most predominant in the pylorus. Serotonin-IR cells were detected throughout the whole GIT and they showed the highest frequency in the fundus. Gastrin- and CCK-IR cells were restricted to the pylorus and duodenum with a majority in the pylorus and rare or a few frequencies in the duodenum. Compared with other mammals, somatostatin-IR cells were restricted to the fundus and pylorus with a few frequencies, respectively. In addition, glucagon- and HPP-IR cells were restricted to the fundus and duodenum, respectively, with relative low frequencies. Some species-dependent unique distributions and frequencies of endocrine cells were observed in the GIT of BALB/c mouse compared with other rodents.

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Effect of Ageing on Colonic Endocrine Cell Population in Mouse

Cited by 19 publications

References 19 publications

The Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in SHK‐1 Hairless Mice: An Immunohistochemical Study

The Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in SHK‐1 Hairless Mice: An Immunohistochemical Study

Aging of the mammalian gastrointestinal tract: a complex organ system

An Immunohistochemical Study of Gastrointestinal Endocrine Cells in the BALB/c Mouse

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