Effect of Aging on the Peripheral Blood Lymphocyte Count

MacKinney, Archie A.

doi:10.1093/geronj/33.2.213

Cited by 53 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7A). Indeed, consistent with data from humans, this phenomenon was clearly attributed to older macaques having significantly lower lymphocyte counts in peripheral blood than younger animals (data not shown) (16). Therefore, we compared the frequency of CD4 ϩ T cells in each group of animals (Fig.…”

Section: Low Level Of Infection Among Dn T Cells In Mangabeyssupporting

confidence: 82%

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

Vinton

Klatt

Harris

et al. 2011

J Virol

View full text Add to dashboard Cite

Many species of African nonhuman primates are natural hosts for individual strains of simian immunodeficiency virus (SIV). These infected animals do not, however, develop AIDS. Here we show that multiple species of African nonhuman primate species characteristically have low frequencies of CD4 ؉ T cells and high frequencies of both T cells that express only the alpha-chain of CD8 and double-negative T cells. These subsets of T cells are capable of eliciting functions generally associated with CD4 ؉ T cells, yet these cells lack surface expression of the CD4 protein and are, therefore, poor targets for SIV in vivo. These data demonstrate that coevolution with SIV has, in several cases, involved downregulation of receptors for the virus by otherwisesusceptible host target cells. Understanding the genetic factors that lead to downregulation of these receptors may lead to therapeutic interventions that mimic this modulation in progressive infections.

show abstract

Section: Low Level Of Infection Among Dn T Cells In Mangabeyssupporting

confidence: 82%

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

Vinton

Klatt

Harris

et al. 2011

J Virol

View full text Add to dashboard Cite

show abstract

“…Between the second and seventh decade a moderate decline in lymphocytes [39] and erythrocytes [40] has been described. When we analyzed DNAm of the three relevant CpG sites (cg02228185 in ASPA , cg25809905 in ITGA2B , and cg17861230 in PDE4C ) in a publicly available dataset of cell type-specific DNAm profiles [41] the results indicated that the age predictions made using our epigenetic aging signature were not evoked by myeloid skewing (Figure S9a in Additional file 1).…”

Section: Resultsmentioning

confidence: 99%

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

et al. 2014

View full text Add to dashboard Cite

BackgroundHuman aging is associated with DNA methylation changes at specific sites in the genome. These epigenetic modifications may be used to track donor age for forensic analysis or to estimate biological age.ResultsWe perform a comprehensive analysis of methylation profiles to narrow down 102 age-related CpG sites in blood. We demonstrate that most of these age-associated methylation changes are reversed in induced pluripotent stem cells (iPSCs). Methylation levels at three age-related CpGs - located in the genes ITGA2B, ASPA and PDE4C - were subsequently analyzed by bisulfite pyrosequencing of 151 blood samples. This epigenetic aging signature facilitates age predictions with a mean absolute deviation from chronological age of less than 5 years. This precision is higher than age predictions based on telomere length. Variation of age predictions correlates moderately with clinical and lifestyle parameters supporting the notion that age-associated methylation changes are associated more with biological age than with chronological age. Furthermore, patients with acquired aplastic anemia or dyskeratosis congenita - two diseases associated with progressive bone marrow failure and severe telomere attrition - are predicted to be prematurely aged.ConclusionsOur epigenetic aging signature provides a simple biomarker to estimate the state of aging in blood. Age-associated DNA methylation changes are counteracted in iPSCs. On the other hand, over-estimation of chronological age in bone marrow failure syndromes is indicative for exhaustion of the hematopoietic cell pool. Thus, epigenetic changes upon aging seem to reflect biological aging of blood.

show abstract

“…The parameters were similar to those identified in a previous study (29), which demonstrated that total white blood cell and lymphocyte counts decrease with age, while neutrophil, monocyte and eosinophil counts increase in mice. However, in humans, lymphocyte counts are significantly decreased in the first two decades and remain constant for the following three decades, and demonstrate a more prominent decrease thereafter (30).…”

Section: Discussionmentioning

confidence: 99%

Age-associated alterations in constitutively expressed cyclooxygenase-2 immunoreactivity and protein levels in the hippocampus

Jung

Yoo

Kim

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Cyclooxygenase-2 (COX-2) is a known inducible inflammatory mediator. COX-2 is constitutively expressed in the hippocampus and may regulate synaptic plasticity. The present study investigated the age-associated alterations in white blood cell counts and hippocampal COX-2 expression in healthy mice using immunohistochemical and western blot analyses at 1 month postnatal (PM1), PM3, PM6, PM12 and PM24. White blood cell counts were significantly decreased in the PM24 group when compared with the PM1 group. In addition, lymphocyte counts were decreased in the PM24 group when compared with all other groups. By contrast, monocyte, neutrophil and eosinophil counts were increased in the PM24 group; however, this did not reach statistical significance. COX-2 expression was identified in the granule cells of the dentate gyrus and in the pyramidal cells of the hippocampal CA2/3 region. COX-2 immunoreactivity was maintained until PM18, however, the levels significantly decreased by PM24. These results suggest that, despite alterations in the differential white blood cell counts, the significant decrease in constitutive COX-2 expression in the hippocampus may be associated with degenerative age-associated alterations in synaptic plasticity in the hippocampus.

show abstract

Effect of Aging on the Peripheral Blood Lymphocyte Count

Cited by 53 publications

References 0 publications

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

Age-associated alterations in constitutively expressed cyclooxygenase-2 immunoreactivity and protein levels in the hippocampus

Contact Info

Product

Resources

About

Effect of Aging on the Peripheral Blood Lymphocyte Count

Cited by 53 publications

References 0 publications

CD4-Like Immunological Function by CD4 − T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

CD4-Like Immunological Function by CD4 − T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

Age-associated alterations in constitutively expressed cyclooxygenase-2 immunoreactivity and protein levels in the hippocampus

Contact Info

Product

Resources

About

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

CD4-Like Immunological Function by CD4 ⁻ T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus