Effect of aging on the autoimmune response to sex accessory glands in male rats

Pistoresi-Palencia, María C.; Galmarini, Mirian; Vottero-Cima, E

doi:10.1016/0165-0378(87)90025-8

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…with FI of RAG,but not with an unrelated antigen,were involved in the induction of MRAG-specific inducer-phase T, cells and that I-A+ PC from FI of RAG-pretreated rats were involved in the induction of cells responsible for the autoimmune response. It is possible that, at least in part, the previously reported potentiation of autoimmune response to RAG in old rats [4], and the diminution of the specific autoimmune suppression presented here, could be due to a reduced ability to present autoantigenic macromolecules of RAG in the I-E context and an enhanced ability to present autoantigens of RAG in the I-A context.…”

Section: Discussionmentioning

confidence: 68%

“…We have previously demonstrated that 12-month-old rats show a higher autoimmune response to RAG than that shown by 3-month-old rats with the same antigen stimulus [4]. Taking into account that the relationship of the senescent immunosuppressor system to the aging process remains poorly understood, in this present report we analyze the suppressor autoimmune system using an experimental model of suppression of autoimmunity to MRAG developed in our laboratory [6].…”

Section: Discussionmentioning

confidence: 86%

“…This was performed as in a previous study [4]. Briefly, washed human red cells of groups 0 Rh+ were treated for 30min at room temperature and 30min at 4°C with a 1/20000 solution of tannic acid.…”

Section: Passive Hemagglutinationmentioning

confidence: 99%

“…We have demonstrated that 12-month-old rats develop a greater autoimmune response to rat male accessory glands (RAG) than 3-month-old rats with the same antigen stimulus [4]. Cell transfer experiments have shown that MQ, are the main type of spleen cells involved in this exacerbation.…”

Section: Introductionmentioning

confidence: 98%

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Effect of aging on the autoimmune response to rat male accessory glands: deficit of I‐E‐positive peritoneal cells capable of inducing suppression

1991

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The present report analyzes the ability to induce suppression to rat male accessory gland (RAG) autoantigens and the characteristics of T suppressor (Ts)-inducer peritoneal cells (PC) in old rats which show increased autoimmune responses. The injection of young rats with a purified fraction (FI) of RAG 10 and 3 days prior to immunization with chemically modified RAG (MRAG) markedly reduced the immune response to RAG autoantigens when compared with young rats which had only been immunized (controls), while the pretreatment of old rats did not block the delayed-type hypersensitivity reaction to MRAG when compared with control old rats. The study of cell surface markers on PC from rats injected i.p. 2 h previously with FI of RAG (FI-PC) showed an increase of OX-6 (I-A) and a decrease of OX-17 (I-E) in FI-PC of old rats with respect to FI-PC of young animals, which showed a selective increase of I-E+ Ts-inducer PC. The i.p. injection of FI-PC from old rats into young recipients, 10 and 3 days prior to immunization with MRAG in complete Freund's adjuvant, did not modify the autoimmune response when compared with controls. By contrast, the injection of young and old rats with FI-PC from young animals induced a significant suppression of the autoimmune response. The reduced percentage of I-E+ suppressor-inducer PC provides an explanation for the diminished ability to induce suppression to RAG autoantigens in old rats.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 86%

Section: Passive Hemagglutinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations