Effect of Al:Mo molar ratio on elution performance of 99Mo/99mTc generators based on Al99Mo gels

AbstractNew iron(III)99Mo-molybdate(VI) gels (Fe99Mo) of high Mo content were prepared by the precipitation/filtration method.99Mo–MoO3dissolved in NaOH was added to aqueous solutions of Fe(NO3)3at Mo/Fe mole fractions ~2.21 and 1.99 with continuous stirring at ambient room temperature. Two different Fe99Mo were precipitated from the mixed solutions adjusted at pH 2 and 4.7. The amount of water of hydration increased with the increasing the gel settling time and pH of the mixed solution. The matrices were characterized by radiometric, XRD, SEM, XRF, FT-IR, TGA, and DTA measurements. Small chromatographic columns of 2.0 g Fe99Mo containing ≥800 mg Mo tagged with 740 MBq99Mo were eluted with 5 mL saline solution. Highly reproducible99mTc elution indices suitable for preparation of99Mo/99mTc generators were achieved from generator supported with 0.5 g Al2O3filter. Elution performance of99mTc radionuclide was highly dependent on the gel structural properties.

show abstract

⁹⁹Mo/^99mTc radioisotope generator based on adsorption of ⁹⁹Mo (VI) on cerium (IV) molybdate column matrix

El-Said

Ramadan

Abbas

et al. 2018

Radiochimica Acta

View full text Add to dashboard Cite

Abstract Based on neutron activated 99Mo, a procedure for preparation of 99Mo/99mTc radioisotope generator was developed. Batch equilibration method was used to investigate the sorption behavior of Mo (VI) (10−4 M) in chloride and nitrate solutions on cerium (IV) molybdate gel matrix using 99Mo radiotracer. The breakthrough sorption capacity of cerium molybdate gel matrix for 99Mo (VI) (3×10−2 M) were found to be 0.54 mmol/g of the sorbent [1 g column (0.6 cm i.d.)]. Elution performance of the generated 99mTc from cerium molybdate-99Mo chromatographic column was investigated as a function of inside diameter of the column, amount of the bed matrix and flow rate of the eluent. Based on the obtained results, 99Mo/99mTc radioisotope generator was prepared based on adsorption of neutron activated 99Mo (VI) of low specific activity onto chromatographic columns packed with 5 g cerium molybdate gel matrix. The radioactivity of 99mTc is periodically eluted with 10 mL 0.9% NaCl solution at a flow rate of 1 mL/min. Elution yield of 78±5% was obtained with high chemical, radionuclidic (99Mo breakthrough 1×10−3±0.3×10−3%) and radiochemical purity (97±2%).

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of Al:Mo molar ratio on elution performance of 99Mo/99mTc generators based on Al99Mo gels

Cited by 3 publications

References 30 publications

Experimental study for the decontamination of various surfaces from 99Mo using PVA/Borax/Al(OH)3 strippable hydrogel

Experimental study for the decontamination of various surfaces from 99Mo using PVA/Borax/Al(OH)3 strippable hydrogel

Preparation and characterization of iron(III) ⁹⁹Mo-molybdate(VI) gels for the assessment of ^99mTc elution performance

⁹⁹Mo/^99mTc radioisotope generator based on adsorption of ⁹⁹Mo (VI) on cerium (IV) molybdate column matrix

Contact Info

Product

Resources

About

Effect of Al:Mo molar ratio on elution performance of 99Mo/99mTc generators based on Al99Mo gels

Cited by 3 publications

References 30 publications

Experimental study for the decontamination of various surfaces from 99Mo using PVA/Borax/Al(OH)3 strippable hydrogel

Experimental study for the decontamination of various surfaces from 99Mo using PVA/Borax/Al(OH)3 strippable hydrogel

Preparation and characterization of iron(III) 99Mo-molybdate(VI) gels for the assessment of 99mTc elution performance

99Mo/99mTc radioisotope generator based on adsorption of 99Mo (VI) on cerium (IV) molybdate column matrix

Contact Info

Product

Resources

About

Preparation and characterization of iron(III) ⁹⁹Mo-molybdate(VI) gels for the assessment of ^99mTc elution performance

⁹⁹Mo/^99mTc radioisotope generator based on adsorption of ⁹⁹Mo (VI) on cerium (IV) molybdate column matrix