Effect of Albendazole Sulfoxide Solution on the Scolices and the Hepatobiliary System

Erzurumlu, Kenan; Hökelek, Murat; Barış, Sancar; Şahi̇n, Mustafa; Bırınci, Asuman; Amanvermez, Ramazan; Tac, Kivanc

doi:10.1159/000008610

Cited by 36 publications

(20 citation statements)

References 14 publications

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“…Various scolicidal agents such as 95% alcohol, 10% povidone iodine, hypertonic saline, hydrogen peroxide, 5% formalin, silver nitrate, cetrimide, and albendazole have been evaluated for scolicidal effects and hepatobiliary complications in the presence of cystobiliary communications (Landa García et al 1997;Topcu et al 2006;Sahin et al 2004 ). Even though 95% Ethyl alcohol had been found to be 100% effective at the end of 15 min (Erzurumlu et al 1998), severe hepatobiliary complications have been reported for alcohol (Yetim et al 2005). Hypertonic salt water (20%) was found to be 99.5% effective at the end of 10 min (Adas et al 2009), but severe hepatobiliary complications have been reported for 10%-20% NaCl ( Topcu et al pH Time ( Meymerian et al (1963), fatal air embolism and anaphylactic shock have been reported with this scolicidal agent by Adas et al (2009).…”

Section: Discussionmentioning

confidence: 99%

“…ABZ sulfoxide is more effective than ABZ sulfone (Adas et al 2009). Twenty microgram per milliliter ABZ sulfoxide killed 5% of the scolices in 15 min, scolicidal activity was 50% with a 50 μg/ mL solution, and it was 100% for a 100 μg/mL solution (Erzurumlu et al 1998). It is known that scolicidal solution injection in the cysts or the biliary system leads to a rise in liver enzyme level.…”

Section: Discussionmentioning

confidence: 99%

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In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst

Moazeni

Larki

2010

Parasitol Res

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The most confident way for treatment of hydatid cyst is surgical operation. Spillage of the cyst contents during the operation is the major cause of recurrence after hydatid cyst surgery. Instillation of scolicidal agent into hydatid cyst is the most commonly employed measure to prevent this complication. In the present study, the scolicidal effect of highly acidic and alkaline solutions is investigated. Protoscoleces were collected aseptically from sheep livers containing hydatid cyst. Acidic solutions with pH 1, 2, 3, and 4 and alkaline solutions with pH 11, 12, 13, and 14 were used for 5,10, and 15 min in the experiments. Viability of protoscoleces was assessed by 0.1% eosin staining. Scolicidal effect of acidic solution with pH 1 after 5 min and with pH 2 and 3 after 10 min was 100%. Scolicidal effect of acidic solution with pH 2 and 3 after 5 min was 99.6% and 98.7%, respectively. Acidic solution with pH 4 after 5, 10, and 15 min killed 15.5%, 21.5%, and 22.6% of protoscoleces, respectively. Alkaline solution with pH 14 after 5 min and with pH 13 after 15 min killed all protoscoleces. The scolicidal effect of alkaline solution with pH 13 after 5 and 10 min was also 97.5% and 99.7%, respectively. These values for alkaline solution with pH 12 were 29.33%, 33.44% and 37.09%, respectively. The scolicidal effect of solution with pH 11 was 24.5%, 30.5%, and 31.3%, respectively. Although the in vitro scolicidal effect of highly acidic or alkaline solutions was satisfactory in our study, in vivo efficacy of these solutions and also possible side effects, remain to be more investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst

Moazeni

Larki

2010

Parasitol Res

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“…Although the efficacy of systemic administration is limited and prolonged exposure of albendazole to the biliary tree promotes caustic sclerosing cholangitis, the effects of the albendazole on the biliary system are do not exceed those of 0.9% NaCl. Nevertheless, Erzurumlu et al [9] showed that albendazole has less toxicity on bile duct than other treatments. Direct cystic injection of these drugs offers the advantage of a high intracystic drug concentration.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effectiveness of Different Chemical Agents on Scolices of Hydatid Cyst

Çağlar

Yüzbaşıoğlu

Bülbüloğlu

et al. 2008

Journal of Investigative Surgery

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In the surgical history of hepatic hydatid disease, multiple scolicidal agents have been used for sterilization of the cyst contents. However, none of these agents can be safely used, because most have unacceptable side effects, such as toxicity, caustic sclerosing cholangitis, bile duct stricture, and hypernatremia. Protoscolices were aseptically removed from liver hydatid cysts obtained from sheep slaughtered at the municipal abattoir in Kahramanmaras, Turkey. In this study, the effects of 0.9% NaCl (control group), 20% NaCl (hypertonic saline), 20% silver nitrate, albendazole 20 mg/cm3, 50% dextrose (hypertonic glucose), and 20% mannitol and aminomix-1 solutions on echinococe cysts were investigated under in vitro conditions. After 5, 10, 15, 20, 25, 30, 45, and 60 min for each concentration, the first 100 protoscolices were counted on the 10x microscopical field. Protoscolices, which showed positive staining by eosine were considered as dead ones. The averages of dead and total protoscolices were calculated. Our results showed that all observed protoscolices were dead after the treatments by 20% silver nitrate in 20 min, by 50% dextrose and by aminomix-1 solution in 30 min, and by 20% NaCl and by 20% mannitol in 45 min. Albendazole at 20 mg/cm3 was observed to lead to death of 65% of protoscolices in the first 5 min and 70% of protoscolices at the end of 60 min. Compared with 0.9% NaCl (saline), all of these scolicidal agents were significantly effective (p < .05). Aminomix-1, 20% mannitol, and 50% dextrose solutions may be used in percutaneous and surgical treatment of hydatid cyst. They may be preferred because they are readily available, can be administered intravenously, and have an equal or greater effectiveness than 20% hypertonic saline.

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“…Furthermore, in farm animals, cystic hydatidosis causes severe economic losses. Although benzimidazole derivatives such as albendazole are used in treatments, there is often an absence of complete recovery after treatment (25). Surgery remains the most effective treatment.…”

Section: Discussionmentioning

confidence: 99%

Arsenic Trioxide Negatively Affects Echinococcus granulosus

Wang

Jiang

Wang

et al. 2015

Antimicrob Agents Chemother

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bSpillage of cyst contents during surgery is the major cause of recurrences of hydatidosis, also called cystic echinococcosis (CE). Currently, many scolicidal agents are used for inactivation of the cyst contents. However, due to complications in the use of those agents, new and more-effective treatment options are urgently needed. The aim of this study was to investigate the in vitro efficacy of arsenic trioxide (ATO) against Echinococcus granulosus protoscolices. Protoscolices of E. granulosus were incubated in vitro with 2, 4, 6, and 8 mol/liter ATO; viability of protoscolices was assessed daily by microscopic observation of movements and 0.1% eosin staining. A small sample from each culture was processed for scanning and transmission electron microscopy. ATO demonstrated a potent ability to kill protoscolices, suggesting that ATO may represent a new strategy in treating hydatid cyst echinococcosis. However, the in vivo efficacy and possible side effects of ATO need to be explored. Hydatidosis, also called cystic echinococcosis (CE), is a severe zoonotic disease caused by the tapeworm Echinococcus granulosus at its larval stage. E. granulosus is distributed worldwide (1). Currently, chemotherapy, puncture with aspiration, and surgery are the three main treatments for hydatid cysts (2), with surgery being one of the best choices for treating hydatidosis (3). The possibility of cyst rupture and protoscolex dissemination can result in secondary CE caused by spillage of a large number of protoscolices; spillage of cyst contents during surgical operation is the major cause of recurrences of the disease (4).Instillation of a scolicidal agent into a hepatic hydatid cyst is the most commonly employed measure to prevent their reoccurrence and attendant complications. Many scolicidal agents have been used for inactivation of cyst contents. The agents can destroy parasites (5), but their use can result in some complications, including acute hypernatremia and intracranial bleeding, leading to convulsions and myelinolysis (6). Therefore, there is a clinical need for safe and effective scolicidal solutions.Arsenic trioxide (As 2 O 3 [ATO]) is the main component of arsenolite, an ancient drug used in traditional Chinese medicine for over 5,000 years (7); it was the first effective chemotherapy against cancer, syphilis, parasites, and leukemia and especially in the treatment of patients suffering from acute promyelocytic leukemia (APL) (8). The solution gained popularity as a feed additive for chickens and pigs to prevent parasitic infestations and weight gain (9). In 1905, Harold Thomas of Liverpool used atoxyl, an arsenic derivative, to kill trypanosomes. From 1830 to 1930, it was used to treat African sleeping sickness (10). Moreover, ATO has been shown to be effective, particularly in combination with other drugs, in chronic myeloid leukemia therapy (11,12).Currently, ATO is approved by the FDA for the treatment of acute promyelocytic leukemia (13). Arsenical drugs are still used for treatment of parasitic diseases such ...

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Effect of Albendazole Sulfoxide Solution on the Scolices and the Hepatobiliary System

Cited by 36 publications

References 14 publications

In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst

In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst

In Vitro Effectiveness of Different Chemical Agents on Scolices of Hydatid Cyst

Arsenic Trioxide Negatively Affects Echinococcus granulosus

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