Effect of Alcohol Extract of &lt;i&gt;Zataria multiflora&lt;/i&gt; (Boiss), &lt;i&gt;Satureja bachtiarica&lt;/i&gt; (Bunge) and &lt;i&gt;Zaravschanica membranacea&lt;/i&gt; (Boiss) on Immuno-Hematologic Factors in Rats

Dehkordi, Hamed Soleyman; Dehkordi, Mohsen Jafarian; Chaleshtori, Milad Rezamand; Khamesipour, Faham; Katsande, S.

doi:10.4314/tjpr.v14i11.7

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…Stimulatory effects of intraperitoneal administration of Z. multiflora essence on the function of innate immunity in BALB/c mice have been shown [120]. Z. multiflora also increased WBS, IgM, monocytes, and phagocytosis in rats [121]. Serum levels of IL-8 were decreased in guinea-pig model of COPD [29] as well as serum level of IgE in guinea-pigs sensitized to ovalbumin [122] were improved by treatment with drinking water containing the extract of Z. multiflora.…”

Section: Immunomodulatory Effectmentioning

confidence: 99%

Pharmacological effects ofZataria multifloraBoiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

Khazdair

Ghorani

Alavinezhad

et al. 2018

Fundamemntal Clinical Pharma

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A B S T R A C TZataria multiflora Boiss (Z. multiflora) belongs to the Lamiaceae family is used traditionally for culinary and medicinal purposes. Different pharmacological effects have been described for the plant including; bronchodilation, vasodilation, and effect on lung inflammation. The plant is also used as a remedy against cough in the traditional medicine. In this article, 'pharmacological effects of Z. multiflora and its constituents focusing on their anti-inflammatory, antioxidant, and immunomodulatory properties were reviewed' by searching various databases until 'June' 2016. The anti-inflammatory effects of the plant such as decreased total white blood cell, neutrophils, and eosinophils counts were demonstrated. The sprotective effects of Z. multiflora on serum levels of phospholipase A2 and total protein were showed. In addition, constituents of the plant, such as flavonoids and carvacrol, also showed anti-inflammatory effects. Z. multiflora also reduced oxidative stress by scavenging free radicals and can be used in the therapy of oxidative damage. Decreased level of malondialdehyde and protective effects of Z. multiflora on serum levels of nitric oxide were also shown. Improvement of the serum levels of IgE, reduction in pro-inflammatory cytokine , and increased anti-inflammatory cytokines (IFN-c and FOXP3) were shown for Z. multiflora and its constituents, carvacrol and thymol. These results indicated that carvacrol and thymol could be used for treatment of inflammatory diseases as new anti-inflammatory agents. Therefore, Z. multiflora showed anti-inflammatory, antioxidant, and immunomodulatory effects which could be used for treatment of inflammatory and immune dysregulation diseases or disorders associated with increased oxidative stress.

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Section: Immunomodulatory Effectmentioning

confidence: 99%

Pharmacological effects ofZataria multifloraBoiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

Khazdair

Ghorani

Alavinezhad

et al. 2018

Fundamemntal Clinical Pharma

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“…23,24,41,42 In this context, oral administration of the extract induced no noticeable change in body weight, hematological parameters, serum biochemical factors, and histopathology, even at a dose of 500 mg/kg. 23,41 Accordingly, shortterm use of the extract does not seem to produce any significant toxicity. However, a limiting factor of this research was the lack of toxicity and safety investigations of ZME, and these should be done in future studies.…”

Section: Discussionmentioning

confidence: 82%

“…Preclinical and clinical studies indicate that there are no major treatment‐related adverse effects following administration of the hydro‐ethnolic extracts of this plant 23,24,41,42 . In this context, oral administration of the extract induced no noticeable change in body weight, hematological parameters, serum biochemical factors, and histopathology, even at a dose of 500 mg/kg 23,41 .…”

Section: Discussionmentioning

confidence: 88%

Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Hosseini

Arab

Beheshti

et al. 2023

Anim Models and Exp Med

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Background: Zataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury. Thus, this study aimed to investigate the effects of Z. multiflora and carvacrol on nitric oxide (NO) and oxidative stress indicators in lipopolysaccharide (LPS)-induced aortic and cardiac injury.Methods: Adult male Wistar rats were assigned to: Control, lipopolysaccharide (LPS)(1 mg/kg, intraperitoneal (i.p.)), and Z. multiflora hydro-ethanolic extract (ZME, 50-200 mg/kg, oral)-and carvacrol (25-100 mg/kg, oral)-treated groups. LPS was injected daily for 14 days. Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration. At the end of the study, the levels of malondialdehyde (MDA), NO, thiols, and antioxidant enzymes were evaluated. Results:Our findings showed a significant reduction in the levels of superoxide dismutase (SOD), catalase (CAT), and thiols in the LPS group, which were restored by ZME and carvacrol. Furthermore, ZME and carvacrol decreased MDA and NO in cardiac and aortic tissues of LPS-injected rats. Conclusions:The results suggest protective effects of ZME and carvacrol on LPSinduced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

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“…In the literature, few articles have reported on the biological properties of S. bachtiarica polar extracts. The ethanol extract from the Satureja species demonstrated an immunostimulant effect in Wistar rats [ 10 ], while the methanol extract was evaluated for its total flavonoid and phenolic content and antioxidant activity [ 7 ]. In a study by Alghooneh et al, the antibacterial and antioxidant capabilities of S. bachtiarica extract had a substantial impact on the characteristics of cheese [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation and Biofilm-Inhibitory Activity of Bachtiari Savory (Satureja bachtiarica Bunge) Aerial Parts

Rahmani Samani,

D’Urso,

Nazzaro

et al. 2023

Plants

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Satureja bachtiarica is an endemic plant from the Lamiaceae family, growing in the Zagros mountain range in Iran. Even if S. bachtiarica is reported to possess many biological activities, little is known about its chemical composition. For this reason, in the present research, a phytochemical investigation of this species was carried out. To have a preliminary metabolite profile of S. bachtiarica, the n-BuOH extract was analyzed using LC-ESI/LTQOrbitrap/MS/MS in negative ion mode, allowing the identification of specialized metabolites belonging to flavonoid, monoterpene, indol, phenylpropanoid, phenolic, lignan, coumarin, biphenyl, and triterpene classes. The LC-MS/MS analysis guided the isolation of compounds, and their structures were characterized using spectroscopic methods including 1D- and 2D-NMR experiments and HRMSn analysis. In this way, a compound never reported before belonging to the biphenyl class was identified. Total flavonoid content of the extract along with the antioxidant activity were assessed. Based on the traditional uses of S. bachtiarica suggesting potential antibacterial properties, an evaluation of the biofilm inhibitory activity of the extract and isolated compounds against mature biofilms of Acinetobacter baumannii, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, and Staphylococcus aureus, as well as their influence on the metabolism of sessile bacterial cells, was conducted. The results evidenced that some compounds including parmentin B, biphenyls, and 1-(1H-indole-3-carboxylate)-β-D-glucopyranoside might inhibit some changes occurring in the bacterial cells, which increases their virulence. In particular, biphenyl derivatives at a concentration of 80 μg/mL were capable of limiting remarkably the mature biofilms of A. baumannii and L. monocytogenes remarkably at a percentage ranging between 52.76% and 75.02%, and they reached an inhibition percentage of 69.28 % against E. coli. Biphenyl derivatives were also effective in exerting an inhibitory action against the mature biofilm of P. aeruginosa (inhibition ranging from 59.38% to 81.08%) and Staphylococcus aureus (inhibition percentage reached 82.94%). Of note, the biphenyl derivatives resulted in being capable of acting on the metabolism of the cells within the biofilm of all five pathogens.

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Effect of Alcohol Extract of <i>Zataria multiflora</i> (Boiss), <i>Satureja bachtiarica</i> (Bunge) and <i>Zaravschanica membranacea</i> (Boiss) on Immuno-Hematologic Factors in Rats

Cited by 11 publications

References 11 publications

Pharmacological effects ofZataria multifloraBoiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

Pharmacological effects ofZataria multifloraBoiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Phytochemical Investigation and Biofilm-Inhibitory Activity of Bachtiari Savory (Satureja bachtiarica Bunge) Aerial Parts

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