Effect of alcoholic, glycolic, and polyester resin additives on the gelation of dilute solution (1%) of methylcellulose

Kundu, Patit Paban; Kundu, M; Sinha, Mantosh K.; Choe, Sang-Rak; Chattopadhayay, D

doi:10.1016/s0144-8617(02)00107-8

Cited by 21 publications

(12 citation statements)

References 13 publications

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“…A study reported that PVA as additive promoted the gelling of methylcellulose based hydrogel. This study suggested the role of PVA as a cosolute, which was dominant over pseudo-surfactancy effect of other additives [33]. Therefore, in this study, long-chain PVA molecules had successfully modulated the drug release profile.…”

Section: Resultsmentioning

confidence: 71%

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

2011

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The objective of this work was to delineate the effect of hydrophilic and hydrophobic polymeric additives on sol–gel transition and release profile of timolol maleate (TM) from poly (ethylene glycol)–poly (ε-caprolactone)– poly (ethylene glycol) (PEG–PCL–PEG)-based thermosensitive hydrogel. Polycaprolactone (hydrophobic additive) and polyvinyl alcohol (PVA) (hydrophilic additive) reduced critical gel concentration of PEG–PCL–PEG triblock polymer. The effect of PCL on sol–gel transition was more pronounced than PVA. However, with PCL no statistically significant difference in release profile was observed. The effect of PVA on release profile was more pronounced, which reduced the cumulative percentage release of TM from 86.4±0.8% to 73.7±1.8% over 316 h. Moreover, cytotoxicity of the hydrogel was also investigated utilizing rabbit primary corneal epithelial culture cells. No significant cytotoxicity of hydrogel alone or in presence of additives was observed. So, polymeric additive strategy serves as a valuable tool for optimizing TM release kinetics from PEG–PCL–PEG hydrogel matrix.

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Section: Resultsmentioning

confidence: 71%

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

2011

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“…The gelling temperature increases with the addition of organic polar solvents miscible with water such as alcohols and glycols, because these solvents enhance the aggregation between MC and water molecules through intermolecular hydrogen bonds [68].…”

Section: Influence Of the Molecular Weight And Concentration On The Mmentioning

confidence: 99%

Methylcellulose, a Cellulose Derivative with Original Physical Properties and Extended Applications

et al. 2015

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This review covers the preparation, characterization, properties, and applications of methylcelluloses (MC). In particular, the influence of different chemical modifications of cellulose (under both heterogeneous and homogeneous conditions) is discussed in relation to the physical properties (solubility, gelation) of the methylcelluloses. The molecular weight (MW) obtained from the viscosity is presented together with the nuclear magnetic resonance (NMR) analysis required for the determination of the degree of methylation. The influence of the molecular weight on the main physical properties of methylcellulose in aqueous solution is analyzed. The interfacial properties are examined together with thermogelation. The surface tension and adsorption at interfaces are described: surface tension in aqueous solution is independent of molecular weight but the adsorption at the solid interface depends on the MW, the higher the MW the thicker the polymeric layer adsorbed. The two-step mechanism of gelation is confirmed and it is shown that the elastic moduli of high temperature gels are not dependent on the molecular weight but only on polymer concentration. Finally, the main applications of MC are listed showing the broad OPEN ACCESSPolymers 2015, 7 778 range of applications of these water soluble cellulose derivatives.

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“…Researchers worked on the effect of salts on the gelation temperature of MC [3][4][5]. Furthermore, some additives, such as glycolic, alcoholic, and polyester resins can cause mutation on gelation properties of MC [6,7].…”

Section: Introductionmentioning

confidence: 99%

Magnetic field responsive methylcellulose-polycaprolactone nanocomposite gels for targeted and controlled release of 5-fluorouracil

Nikjoo

Aroguz

2015

International Journal of Polymeric Materials and Polymeric Biom

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ABSTRACT5-Fluorouracil loaded magnetic field sensitive methylcellulose and polycaprolactone gels were prepared and characterized by FTIR, XRD, TGA, SEM, and VSM. Swelling analysis supplied important information on drug diffusion properties. The release profile of gels was investigated in different buffer solutions and the highest release values were observed at pH ¼ 7.2. Release kinetic was analyzed using an empirical equation to clarify the transport properties of drug. The effects of nanoparticle concentration and applying external magnetic field were investigated on release profile. The results indicated that the drug release decreased by both, applying external magnetic field and increasing the concentration of Fe 3 O 4 nanoparticles. GRAPHICAL ABSTRACT ARTICLE HISTORY

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Effect of alcoholic, glycolic, and polyester resin additives on the gelation of dilute solution (1%) of methylcellulose

Cited by 21 publications

References 13 publications

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

Methylcellulose, a Cellulose Derivative with Original Physical Properties and Extended Applications

Magnetic field responsive methylcellulose-polycaprolactone nanocomposite gels for targeted and controlled release of 5-fluorouracil

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