Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial

Kobyliak, Nazarii; Kondratiuk, Kateryna; Kyriienko, Dmytro; Mykhalchyshyn, Galyna

doi:10.1530/endoabs.49.oc2.4

Cited by 6 publications

(5 citation statements)

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“…Experimental studies in mice show mostly beneficial effects in the models of T2D such as L. plantarum [44À47], L. reuteri [48], L. casei [49], L. curvatus [50], L. gasseri [51], L. paracasei [52], L. rhamnosus [53], L. sakei [54]. More importantly, twenty-five human clinical trials [55À79] employed twelve different species of Lactobacillus with ten of those studies [55][56][57][58][59][60][61][62]64,79] adding other probiotics. Out of eleven studies [58À64, 72,76,77,79] that showed some protective effect, the majority combined other genera, most frequently Bifidobacterium [58À62, 64,79], suggesting that Lactobacillus and Bifidobacterium may work in a synergistic manner.…”

Section: Bacteria Involved In T2dmentioning

confidence: 99%

“…More importantly, twenty-five human clinical trials [55À79] employed twelve different species of Lactobacillus with ten of those studies [55][56][57][58][59][60][61][62]64,79] adding other probiotics. Out of eleven studies [58À64, 72,76,77,79] that showed some protective effect, the majority combined other genera, most frequently Bifidobacterium [58À62, 64,79], suggesting that Lactobacillus and Bifidobacterium may work in a synergistic manner. Species L. sporogenes [76,77], L. casei Shirota [63], L. reuteri [72] used as monoprobiotics have been reported to improve T2D related symptoms in humans.…”

Section: Bacteria Involved In T2dmentioning

confidence: 99%

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Role of gut microbiota in type 2 diabetes pathophysiology

et al. 2020

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A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D.

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Section: Bacteria Involved In T2dmentioning

confidence: 99%

Section: Bacteria Involved In T2dmentioning

confidence: 99%

Role of gut microbiota in type 2 diabetes pathophysiology

et al. 2020

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“…Administration of probiotic Lactobacillus and Bifidobacterium lessened insulin resistance in HFD-fed mice [ 15 ]. In humans, a multi-probiotic, Bifidobacterium , Lactobacillus , Lactococcus , and Propionibacterium lowered insulin resistance as estimated by the homeostasis model assessment-estimated insulin resistance (HOMA-IR) in patients with type 2 diabetes [ 16 ]. Administration of prebiotics is also a promising approach to alleviate the development of insulin resistance in humans [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts

Watanabe

Tochio

Kadota³

et al. 2021

Nutrients

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Insulin resistance leads to the onset of medical conditions such as type 2 diabetes, and its development is associated with the alteration in the gut microbiota. Although it has been demonstrated that supplementation with prebiotics modulates the gut microbiota, limited evidence is available for effects of prebiotics on insulin resistance, especially for humans. We investigated the prebiotic effect of 1-kestose supplementation on fasting insulin concentration in obesity-prone humans and rats. In the preliminary study using rats, the hyperinsulinemia induced by high-fat diet was suppressed by intake of water with 2% (w/v) 1-kestose. In the clinical study using obese-prone volunteers, the fasting serum insulin level was significantly reduced from 6.5 µU/mL (95% CI, 5.5–7.6) to 5.3 (4.6–6.0) by the 12-week intervention with supplementation of 10 g 1-kestose/day, whereas it was not changed by the intervention with placebo (6.2 µU/mL (5.4–7.1) and 6.5 (5.5–7.6) before and after intervention, respectively). The relative abundance of fecal Bifidobacterium was significantly increased to 0.3244 (SD, 0.1526) in 1-kestose-supplemented participants compared to that in control participants (0.1971 (0.1158)). These results suggest that prebiotic intervention using 1–kestose may potentially ameliorate insulin resistance in overweight humans via the modulation of the gut microbiota. UMIN 000028824.

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“…and Lactobacillus ( L .) daily for four consecutive weeks improves the plasma fasting insulin and HOMA-IR in women diagnosed with gestational diabetes mellitus (GDM) between 24–28 weeks (Kijmanawat et al, 2019), compared to the placebo group; 2) In another randomized clinical trial (RCT) in Ukraine, supplementation of multi-probiotics, including concentrated biomass of 14 probiotic bacteria genera Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium for eight weeks, was associated with the reduction of HOMA-IR in individuals with type 2 diabetes (Kobyliak et al, 2018). Both trials used probiotics that contain Bifidobacterium and Lactobacillus , two common bacteria for probiotics, as that used in our study; 3) A meta-analysis of six RCTs involved 830 patients also confirmed that supplementation of probiotics significantly reduced the serum fasting insulin and HOMA-IR in women with GDM (Pan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Probiotic supplements reduce antipsychotic-induced metabolic disturbances in drug-naïve first-episode schizophrenia

Kang

Zhang

Yang

et al. 2021

Preprint

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Probiotic supplements have demonstrated efficacy in improving metabolic abnormalities and may prevent antipsychotic-induced metabolic disturbance and weight gain. A few studies in rodents have found that antipsychotic-induced metabolic dysfunctions are associated with the altered composition of gut microbiota. Here, we conducted a randomized-controlled clinical trial to determine the effectiveness and safety of probiotic supplements on antipsychotic-induced metabolic disturbance and weight gain. Patients with drug-naive first-episode schizophrenia were randomized to receive either olanzapine plus probiotics or olanzapine monotherapy and scheduled to evaluate with follow-ups for clinical and metabolic profiles. After a treatment of 12 weeks with addition of probiotics, the increase of mean fasting insulin was significantly lower than olanzapine monotherapy. Insulin resistance increased considerably in the olanzapine plus probiotics, but also significantly lower than olanzapine monotherapy. We noted a difference in the increase in body mass index and body weight between treatments at a nominal level of significance, but it became non-significant after adjusting for appetite increase. Probiotics concurrently used with olanzapine is effective and safe in attenuating antipsychotic-induced elevation of fasting insulin and insulin resistance, but not the weight gain in drug-naive first-episode schizophrenia. Further study is warranted to assess the longer-term maintenance of efficacy and safety.

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Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial

Cited by 6 publications

References 0 publications

Role of gut microbiota in type 2 diabetes pathophysiology

Role of gut microbiota in type 2 diabetes pathophysiology

Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts

Probiotic supplements reduce antipsychotic-induced metabolic disturbances in drug-naïve first-episode schizophrenia

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