Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort—FIRCOV

Gochicoa‐Rangel, Laura; Arce, Santiago C.; Aguirre-Franco, Carlos; Madrid-Mejía, Wilmer; Gutiérrez-Clavería, Mónica; Noriega-Aguirre, Lorena; Schönffeldt-Guerrero, Patricia; Izcaray, Agustín Acuña; Cortés-Télles, Arturo; Martínez-Valdeavellano, Luisa; Hernández-Rocha, Federico Isaac; Ceballos-Zúñiga, Omar; Hidalgo, Rodrigo Del Rio; Sánchez, Sonia; Meneses-Tamayo, Erika; Chérrez-Ojeda, Iván

doi:10.1089/ham.2022.0062

Cited by 2 publications

(6 citation statements)

References 37 publications

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“…Comparative evidence indicated that COVID-19 survivors residing at higher altitudes had lower resting PO 2 S compared to those at lower altitudes [2]. PO 2 S values of 92-93% were found in high-altitude COVID-19 survivors [2], equal to 94.2% (±7.9) in COVID-19 patients [10].…”

Section: Discussionmentioning

confidence: 88%

“…Low PO 2 S was associated with higher mortality, even at low altitudes [3]. PO 2 S was also lower in COVID-19 survivors living at high altitudes compared to those living at lower altitudes (2 to 1566 MASL) [2,3] and lower in those diagnosed with severe COVID-19 compared to those with moderate and mild COVID-19 [2].…”

Section: Introductionmentioning

confidence: 82%

“…To categorize ICU stay durations into two intra-group categories, namely "≤11 days" and ">11 days", we utilized the median value (50th percentile) of the ICU stay. This approach was adopted in alignment with a previously conducted epidemiological study on COVID-19 at altitude [2], which had employed a similar percentile for classification purposes. Similarly, from the vital signs, we employed arterial oxygen saturation (PO 2 S) as a noninvasive and indirect method to establish dichotomous altitude categories.…”

Section: Discussionmentioning

confidence: 99%

“…One of the main challenges presented by COVID-19 was its effect on patients' respiratory systems, potentially leading to severe respiratory distress and even death. Research indicates that a mere 1% decrease in oxygen saturation levels before hospitalization escalates the risk of death from COVID-19 by 13% [1], contributing to over 2 million deaths in Latin America [2]. Notably, mortality rates from the virus were lower in individuals residing at higher altitudes [2], likely due to the protective physiological barrier generated by high altitude conditions [3].…”

Section: Introductionmentioning

confidence: 99%

“…Research indicates that a mere 1% decrease in oxygen saturation levels before hospitalization escalates the risk of death from COVID-19 by 13% [1], contributing to over 2 million deaths in Latin America [2]. Notably, mortality rates from the virus were lower in individuals residing at higher altitudes [2], likely due to the protective physiological barrier generated by high altitude conditions [3]. High altitude is defined as between 2500 and 3600 m above sea level (MASL), while extreme altitude ranges from 3600 to 5500 MASL.…”

Section: Introductionmentioning

confidence: 99%

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O2 Saturation Predicted the ICU Stay of COVID-19 Patients in a Hospital at Altitude: A Low-Cost Tool for Post-Pandemic

Vásquez-Gómez,

Gutierrez-Gutierrez,

Miranda-Cuevas

et al. 2024

Medicina

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Background and Objectives: Patients at high altitudes with COVID-19 may experience a decrease in their partial oxygen saturation (PO2S) levels. The objective was to assess the association between PO2S and intensive care unit (ICU) stay in patients at high altitudes with COVID-19. Materials and Methods: Clinical records of 69 COVID-19 patients (36% women) admitted to the ICU were analyzed. Median values were considered for intra-group categories (“≤11 days” and “>11 days” in the ICU) and for PO2S height categories (“<90%” and “≥90%”). Logistic regression and linear regression models adjusted for confounding variables were used. Results: Patients with >11 days in the ICU had 84% lower odds of having a PO2S ≥ 90% (OR: 0.16 [CI: 0.02, 0.69], p = 0.005) compared to those with ≤11 days in the ICU. An increase in PO2S by 1% reduced ICU stay by 0.22 days (β: −0.22 [CI: −0.33, −0.11], p < 0.001), potentially leading to a reduction of up to 1.44 days. Conclusions: PO2S is a crucial factor in estimating ICU stays for COVID-19 patients at high altitudes and serves as an accessible and cost-effective measure. It should be used in infected patients to complement the prognosis of post-pandemic ICU stay.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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O2 Saturation Predicted the ICU Stay of COVID-19 Patients in a Hospital at Altitude: A Low-Cost Tool for Post-Pandemic

Vásquez-Gómez,

Gutierrez-Gutierrez,

Miranda-Cuevas

et al. 2024

Medicina

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Modeling mortality risk in patients with severe COVID-19 from Mexico

et al. 2023

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BackgroundSevere acute respiratory syndrome caused by a coronavirus (SARS-CoV-2) is responsible for the COVID-19 disease pandemic that began in Wuhan, China, in December 2019. Since then, nearly seven million deaths have occurred worldwide due to COVID-19. Mexicans are especially vulnerable to the COVID-19 pandemic as Mexico has nearly the worst observed case-fatality ratio (4.5%). As Mexican Latinos represent a vulnerable population, this study aimed to determine significant predictors of mortality in Mexicans with COVID-19 who were admitted to a large acute care hospital.MethodsIn this observational, cross-sectional study, 247 adult patients were consecutively admitted to a third-level referral center in Yucatan, Mexico, from March 1st, 2020, to August 31st, 2020, with COVID-19-related symptoms, participated in this study. Lasso logistic and binary logistic regression were used to identify clinical predictors of death.ResultsAfter a hospital stay of about eight days, 146 (60%) patients were discharged; however, 40% died by the twelfth day (on average) after hospital admission. Out of 22 possible predictors, five crucial predictors of death were found, ranked by the most to least important: (1) needing to be placed on a mechanical ventilator, (2) reduced platelet concentration at admission, (3) increased derived neutrophil to lymphocyte ratio, (4) increased age, and (5) reduced pulse oximetry saturation at admission. The model revealed that these five variables shared ~83% variance in outcome.ConclusionOf the 247 Mexican Latinos patients admitted with COVID-19, 40% died 12 days after admission. The patients’ need for mechanical ventilation (due to severe illness) was the most important predictor of mortality, as it increased the odds of death by nearly 200-fold.

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Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort—FIRCOV

Cited by 2 publications

References 37 publications

O2 Saturation Predicted the ICU Stay of COVID-19 Patients in a Hospital at Altitude: A Low-Cost Tool for Post-Pandemic

O2 Saturation Predicted the ICU Stay of COVID-19 Patients in a Hospital at Altitude: A Low-Cost Tool for Post-Pandemic

Modeling mortality risk in patients with severe COVID-19 from Mexico

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