Effect of aluminum chloride on the hippocampus of adult rats and the possible protective role of Nigella sativa

Kamel, Esam S.; Mostafa, Nashwa

doi:10.1097/01.ehx.0000429819.42144.0a

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…9, C2 and D2). Buraimoh et al and Kamel et al found that rats exposed to oral AlCl 3 administration showed neuronal degeneration in various hippocampal areas [69,70]. Interestingly, Congo red staining confirmed a slight positive reactivity of amyloid plaques that could be seen in the brains of AlCl 3 -treated rats [6].…”

Section: Histopathological Examinationmentioning

confidence: 93%

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

Abdelghany

Gamal

Abdel‐Wahab

et al. 2023

Drug Deliv. and Transl. Res.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by memory loss, changes in behavior, and avoidance of social bonds. Aluminum is one of the main risk factors in the development of AD. Spirulina platensis (SP) is a microalga that improves motor and cognitive skills and prevents cerebral endothelial damage. SP could be delivered in a more controlled and targeted manner using nanoparticles like niosomes. The purpose of this research was to develop a SP-loaded niosome (SPLN) formulation as a drug delivery system to investigate the effectiveness and toxicity of SP as an AD therapy using the AlCl3-induced AD rat model. A niosomal formulation that consists of Tween 60, cholesterol, and dihexadecyl phosphate in a molar ratio of 1:2:0.1 was chosen as an optimum formulation. AD was induced in rats by orally administering AlCl3. Compared with the AlCl3 control, the group treated with the SPLN formulation showed enhancement of the recognition and working memories by increasing the difference score, the discrimination ratio, and the spontaneous alternation behavior. Additionally, it revealed a significant increase in AchE genes, restored the reduced brain neurotransmitters, and improved brain oxidative status. In conclusion, SPLN formulation could be considered an effective AD therapy. Graphical Abstract

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Section: Histopathological Examinationmentioning

confidence: 93%

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

Abdelghany

Gamal

Abdel‐Wahab

et al. 2023

Drug Deliv. and Transl. Res.

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show abstract

“…Çabuş, Oğuz [47] Found 3 mg / ml of aluminum sulfate injected IP rats everyday for two weeks of toxic effects of aluminum on hippocampus rats. Kamel and Mostafa [48] Found histologically and ultrastructure damage of hippocampous of rat received aluminum chloride added to water for 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Histological study on the acute injection of aluminum sulfate on different organs of rats

El-Hak

Eladawy

Rashwan

et al. 2020

Frontiers in Scientific Research and Technology

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Neuro-protective and Neuro-curative effect of Vernonia Amygdalina in rat model of neurodegenerative disease

Ajeleti

Akunna

Ojo

et al. 2023

Journal of Trace Elements and Minerals

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Effect of aluminum chloride on the hippocampus of adult rats and the possible protective role of Nigella sativa

Cited by 5 publications

References 20 publications

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

RETRACTED ARTICLE: Evaluating the neuroprotective effect of Spirulina platensis–loaded niosomes against Alzheimer’s disease induced in rats

Histological study on the acute injection of aluminum sulfate on different organs of rats

Neuro-protective and Neuro-curative effect of Vernonia Amygdalina in rat model of neurodegenerative disease

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