2022
DOI: 10.1038/s41598-022-18534-9
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Effect of amide protoporphyrin derivatives on immune response in Apis mellifera

Abstract: The intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling Nosema infection without adverse effects on honeybees. In the present work, the impact of two protoporphyrin IX derivatives, i.e. PP[Asp]2 and PP[Lys]2, on Apis mellifera humoral immune response has been investigated in laboratory conditions in non-infected and N. ceranae-infected honeybee… Show more

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Cited by 3 publications
(1 citation statement)
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“…Fast and reliable methods for measuring non-invasive endpoints in living bees are needed. Until now, most studies have focused on the effects of one or multiple stress factors on cellular processes, survival and humoral immune response ( Hartfelder et al, 2013 ; Havard, Laurent, and Chauzat, 2019 ; Trytek et al, 2022 ). Other studies focus on behavioural changes, brood development, number of mites or spores counted or estimated ( Henry et al, 2017 ; Bird et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Fast and reliable methods for measuring non-invasive endpoints in living bees are needed. Until now, most studies have focused on the effects of one or multiple stress factors on cellular processes, survival and humoral immune response ( Hartfelder et al, 2013 ; Havard, Laurent, and Chauzat, 2019 ; Trytek et al, 2022 ). Other studies focus on behavioural changes, brood development, number of mites or spores counted or estimated ( Henry et al, 2017 ; Bird et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%