1978
DOI: 10.1007/bf00609758
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Effect of aminoglycosides on proximal tubular membranes of the human kidney

Abstract: The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 mg/kg additionally seven subjects amikacin 10 mg and six subjects netilmicin 6 mg on three consecutive days. The principal enzyme of the brush border membrane of the proximal tubule, alanine aminop… Show more

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Cited by 104 publications
(35 citation statements)
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“…The best known markers are N-acetyl-beta-D-glucosaminidase (NAG), alanine-aminopeptidase and ß2-microglobulin (11). Comparative studies regarding the predictive value of these enzymes for the evaluation of gentamicin nephrotoxicity have revealed the efficacy and superiority of NAG over the other markers, a fact attributable to the proportional relationship between NAG and gentamicin-induced renal damage (11).…”
Section: Groups (N)mentioning
confidence: 99%
“…The best known markers are N-acetyl-beta-D-glucosaminidase (NAG), alanine-aminopeptidase and ß2-microglobulin (11). Comparative studies regarding the predictive value of these enzymes for the evaluation of gentamicin nephrotoxicity have revealed the efficacy and superiority of NAG over the other markers, a fact attributable to the proportional relationship between NAG and gentamicin-induced renal damage (11).…”
Section: Groups (N)mentioning
confidence: 99%
“…At intervals of 1 week 0.5-, 1-, and 2-g doses of cefotaxime were administered to each volunteer over 15 min, followed by sustaining infusions of 0.5, 1, and 2 g/h, respectively, for 3 consecutive hours ( In addition to these parameters, a specific attempt was made to evaluate the effect of cefotaxime on the proximal tubules of the kidney. AAP is an enzyme located primarily on the brush border membranes of the renal tubules, and several authors have demonstrated that damage to the proximal tubules (either drug induced or due to an inflammatory process) is reproducibly associated with an increased urinary AAP output (4,(18)(19)(20)(21)25). AAP activity was determined by a spectrophotometric method using alaninep-nitranilide (Roche Reagents; catalog no.…”
Section: Materiais and Merhodsmentioning
confidence: 99%
“…One area of research interest is based on assessing the alterations the aminoglycosides elicit on transport and enzymatic processes located on the apical and basolateral membranes of the proximal tubule cell. For the apical membrane, previous studies have shown that treatment with aminoglycosides elicits an increase in the excretion of brush-border membrane (BBM)-bound enzymes and a decrease in the activity of these enzymes in proximal tubule cells (1,13,19,22), an increase in the urinary excretion of glucose and amino acids and a decrease in BBM-bound and proximal tubule cell Na-dependent glucose transport activity (8,11,13), as well as alterations in BBM vesicle Na-dependent phosphate transport and Na+-H+ exchange (12). Evidence for damage to the basolateral membrane includes reported decreases in the activity of Na+, K+-ATPase (4) and an inhibition of fluoridestimulated adenylate cyclase (31).…”
Section: Introductionmentioning
confidence: 99%