Effect of aminophospholipid glycation on order parameter and hydration of phospholipid bilayer

Obšil, Tomáš; Amler, Evžen; Obšilová, Veronika; Pavlı́ček, Zdeněk

doi:10.1016/s0301-4622(99)00067-8

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…Like proteins, lipids (PE) can be modified by glycation during the development of hyperglycemia. PE glycation is likely to induce changes in the biosynthesis and turnover of membrane phospholipids, the physical properties of membranes, the activity of membrane-bound enzymes, and the susceptibility to oxidative stress [9,[18][19][20]. These changes may contribute to diabetogenesis and the development of diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Amadori‐Glycated Phosphatidylethanolamine, a Potential Marker for Hyperglycemia, in Streptozotocin‐Induced Diabetic Rats

Sookwong

Nakagawa

Fujita

et al. 2011

Lipids

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It has been demonstrated in vivo that lipid glycation products such as Amadori-glycated phosphatidylethanolamine (Amadori-PE) accumulate in the plasma of diabetic humans and animals, but how lipid glycation products are formed under hyperglycemic conditions are not clear. We sought to clarify the occurrence of lipid glycation and its relationships with lipid peroxidation and protein glycation during the development of hyperglycemia using the streptozotocin (STZ)-induced diabetic rat model. A significant increase in Amadori-PE was observed in STZ rats 7 days after STZ treatment, and Amadori-PE (especially 18:0-20:4 Amadori-PE) was found at high levels in the blood and in organs that are strongly affected by diabetes, such as the kidney. Significant changes in Amadori-PE appeared to occur prior to changes in levels of oxidized lipids, which increased after 21-28 days. In addition, accumulation of Nε-(carboxymethyl)lysine (CML), a protein glycation product, proceeded somewhat more slowly and moderately than that of Amadori-PE, suggesting that Amadori-PE and CML are early and advanced glycation products, respectively. Our results suggest that Amadori-PE may be a useful predictive marker for hyperglycemia, particularly in the early stages of diabetes. Similar speculations have been made from previous human studies, but this study provides a direct evidence to support the speculations in rat study.

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Section: Discussionmentioning

confidence: 99%

Amadori‐Glycated Phosphatidylethanolamine, a Potential Marker for Hyperglycemia, in Streptozotocin‐Induced Diabetic Rats

Sookwong

Nakagawa

Fujita

et al. 2011

Lipids

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“…This may be related to the fact that Amadori-PE and carboxymethyllysine are early and advanced glycation products, respectively ( 29,30 ). To put it another way, Amadori-PE may be used as a potentially sensitive marker for refl ecting hyperglycemic conditions in the early stage of diabetes (31)(32)(33). In summary, we developed the LC-MS/MS assay for CM-PE and CE-PE and provided direct information on the molecular species of AGE-PE in human erythrocytes and plasma.…”

Section: Discussionmentioning

confidence: 99%

LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma

Shoji

Nakagawa

Asai

et al. 2010

Journal of Lipid Research

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“…Glycation of PE increases membrane lipid order and lipid hydration, suggesting that formation of N -glycated PE also leads to formation of lipid fragments by oxidation (Obsil et al, 1999). Ravandi et al showed that that increased levels of N -glycated PE in LDL correlated with increases in both hydroperoxides and lipid aldehydes (Ravandi et al, 2000).…”

Section: Class Iv: Oxidatively N-modified Phospholipids (Pl)mentioning

confidence: 99%

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

Davies

Guo

2014

Chemistry and Physics of Lipids

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Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease.

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Effect of aminophospholipid glycation on order parameter and hydration of phospholipid bilayer

Cited by 8 publications

References 33 publications

Amadori‐Glycated Phosphatidylethanolamine, a Potential Marker for Hyperglycemia, in Streptozotocin‐Induced Diabetic Rats

Amadori‐Glycated Phosphatidylethanolamine, a Potential Marker for Hyperglycemia, in Streptozotocin‐Induced Diabetic Rats

LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

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