Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment

Abstract

A 7-day course of either cephradine or amoxicillin-clavulanate treatment caused no significant change in fecal flora composition, except that staphylococci were virtually eliminated in both groups. Some amoxicillin-resistant coliforms were isolated after treatment in both groups, but cephradine- or amoxicillin-clavulanate-resistant coliforms were rarely isolated.

Effects of treatment with antimicrobial agents on the human colonic microflora

“…Cefotaxime decreased both enterobacteria and enterococci in one trial. Cephaloridine (Ambrose et al 1985) and cephradine (Brumfitt et al 1986) had little effect. However, resistant bacterial strains developed as the result of administration of all of these drugs except for cephradine, ceftazidime and cef-buperazone.…”

Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans

“…Therefore, it is important to describe in detail all of its effects on health, including influences on microflora and immunity. Some papers have already described the impact of AMC on fecal and pharyngeal human microflora [11,12]. AMC has already been found to affect in vitro cytokine production by polymorphonuclear cells [13,14], and to enhance phagocytic and microbicidal activities [15].…”

Effects of ceftriaxone on faecal flora: analysis by micromorphometry

“…This balance is sensitive to antibiotic treatment [1]. Various methods have been employed to study this influence: aerobic and anaerobic culturing [2][3][4][5][6][7][8], determination of the fatty acid pattern in faeces [3,9], and microflora associated characteristics [10,11].…”