Effect of ampicillin and oxacillin on fetal and neonatal development

Korzhova, V V; Lisitsyna, N. T.; Mikhailova, E. G.

doi:10.1007/bf00835398

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Interestingly, this diagnosis supports the findings in two earlier animal studies [10,11]. In the former study, the administration of high dose of ampicillin to the pregnant rats in the first and second part of their pregnancy was associated with lower birth weight in the offspring without signs of maternal toxicity [10]. When these findings and the absence of the major risk factors in the mother are taken together, a question whether the FGR in the present case could be associated with high-dose ampicillin exposure is raised [9].…”

Section: Discussionsupporting

confidence: 92%

“…However, FGR was identified based on the findings of fetal distress, low APGAR score, fetal weight compatible with 10% percentile, and meconium aspiration [9]. Interestingly, this diagnosis supports the findings in two earlier animal studies [10,11]. In the former study, the administration of high dose of ampicillin to the pregnant rats in the first and second part of their pregnancy was associated with lower birth weight in the offspring without signs of maternal toxicity [10].…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Pregnancy outcome following intentional ampicillin and pyridium overdose during the second trimester: a case report

Yılmaz¹,

Karadaş²,

Aydoğmuş³

et al. 2019

Clin. Exp. Obstet. Gynecol.

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There are no data focusing on the safety of overdose of ampicillin and pyridium during pregnancy. This study aims to report the outcome of a pregnant woman with an acute overdose of oral ampicillin+pyridium in the 14 th week of pregnancy. A 27-year-old woman was referred to Teratology Information Service with a suicide history of ingesting 28 ampicillin+pyridium (500+50 mg) tablets. A structured, evidence-based counseling regarding her exposure to overdosing was provided, and she decided to continue her pregnancy. She gave birth to a baby in the 38 th gestational week with fetal growth restriction (FGR), with no major congenital malformations and/or deformations. The follow-up of the infant in the 14 th month of her life revealed normal physical and neurodevelopmental findings. Because the mother had no major risk factors and exposure of experimental animals to this overdosage have yielded comparable results, and the FGR in this case may be attributed to medication exposure.

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Section: Discussionsupporting

confidence: 92%