Effect of an antioxidant drink on homocysteine levels in Alzheimer's patients

Morillas-Ruiz, Juana María; Rubio-Pérez, José Miguel; Albaladejo, M. D.; Zafrilla, Pilar; Parra, Soledad; Vidal-Guevara, M.L.

doi:10.1016/j.jns.2010.08.050

Cited by 42 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, a great deal of interest has been generated in the effectiveness of antioxidants to treat oxidative stress related diseases. For instance, melatonin (Cardinali et al, 2010), diets rich in polyphenols (Morillas-Ruiz et al, 2010), Vitamin E (Sano et al, 1997) and Vitamin C (Engelhart et al, 2002, Morris et al, 2002) have all been shown to have ameliorating effects for Alzheimer’s Disease patients, whereas, the antioxidants derived from Gingko biloba (DeKosky et al, 2008) and Curcumin (Baum et al, 2008) were not found to be as effective. Similarly, the relationship between antioxidant supplements and cancer has also been largely inconclusive with a few trials indicating minor protective effects (Goodman et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A survey of the protective effects of some commercially available antioxidant supplements in genetically and chemically induced models of oxidative stress in Drosophila melanogaster

Vrailas-Mortimer

Gomez

Dowse

et al. 2012

Experimental Gerontology

View full text Add to dashboard Cite

Oxidative stress remains one of the most well studied, albeit somewhat contentious, causes of aging-related changes in humans. Consequently, a large number of putative antioxidant compounds are freely available in myriad formulations that are often not tested for their efficacy or regulated for quality control. Following the development of a Drosophila model of oxidative-stress dependent aging (p38 MAP Kinase (p38K) mutants) in our laboratory, we attempted to test the protective effect of some of these commonly available formulations against oxidative stress, stress induced motor defects and reduced life span in the p38K model. As environmental exposure to oxidizing toxins has been linked to a variety of human diseases, we also tested the efficacy of these supplements on chemically-induced models of oxidative stress (Paraquat and Hydrogen Peroxide exposure). Our results suggest that when added as a dietary supplement, some of these over-the-counter compounds, notably containing Açai extracts, confer significant protection for both the p38K-dependent genetic model as well as the toxin-induced model. These products were also remarkably effective at dampening stress-induced expression of the detoxifying enzyme GSTD1 and eliminating Paraquat induced circadian rhythm deficits. Overall, our results suggest potential benefits of dietary supplementation with some of these compounds, especially under conditions of elevated oxidative stress. These findings should be assessed in the context of other studies that seek to identify active principles in these extracts, determine their effective dosage for human consumption and evaluate the safety of long-term prophylactic applications.

show abstract

Section: Introductionmentioning

confidence: 99%

A survey of the protective effects of some commercially available antioxidant supplements in genetically and chemically induced models of oxidative stress in Drosophila melanogaster

Vrailas-Mortimer

Gomez

Dowse

et al. 2012

Experimental Gerontology

View full text Add to dashboard Cite

show abstract

“…Since polyphenols can normalize plasma homocysteine levels in humans, one double-blind placebocontrolled study on the effect of brisk consumption of 200 ml drink rich in antioxidant polyphenols from apple, lemon concentrate juice, apple, green tea extracts, and vitamins B and C on total plasma homocysteine levels in AD patients (initial and moderate phase) has been done (Table 5 ). Eight-month consumption of this drink signifi cantly attenuated the rise of homocysteine level along with time in AD patients especially in those with moderate phase (Morillas-Ruiz et al 2010 ). However, in any studied group (AD patients and age-, sex-, BMI-matched controls), the homocysteine levels after intervention were not lower than at the baseline (Morillas-Ruiz et al 2010 ).…”

Section: Interventional Studies: Results Of Randomized Double-blindmentioning

confidence: 90%

“…Eight-month consumption of this drink signifi cantly attenuated the rise of homocysteine level along with time in AD patients especially in those with moderate phase (Morillas-Ruiz et al 2010 ). However, in any studied group (AD patients and age-, sex-, BMI-matched controls), the homocysteine levels after intervention were not lower than at the baseline (Morillas-Ruiz et al 2010 ). Therefore, the effect of this treatment was rather weak because it did not decrease (normalized) but only inhibited the rise of total plasma homocysteine levels in AD patients.…”

Section: Interventional Studies: Results Of Randomized Double-blindmentioning

confidence: 90%

Antioxidant Plant Polyphenols and Cognitive Disorders

Nowak

2014

Oxidative Stress in Applied Basic Research and Clinical Practice

View full text Add to dashboard Cite

“…The therapeutic effect of 8 months treatment with an antioxidant drink containing polyphenols, vitamins B and C for AD treatment was tested in a RCT enrolling 48 mild and moderate AD patients and 52 age-matched controls [159]. Daily consumption of the antioxidant and vitamin drink for a relatively short time led to a smaller increase in Hcy levels, compared with the placebo group, not only in cognitively healthy subjects, but also in patients with moderate AD.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Inadequate supply of vitamins and DHA in the elderly: Implications for brain aging and Alzheimer-type dementia

Mohajeri¹,

Troesch²,

Weber³

2015

Nutrition

103

View full text Add to dashboard Cite

Alzheimer's disease (AD) is the most prevalent, severe, and disabling cause of dementia worldwide. To date, AD therapy is primarily targeted toward palliative treatment of symptoms rather than prevention of disease progression. So far, no pharmacologic interventions have changed the onset or progression of AD and their use is accompanied by side effects. The major obstacle in managing AD and designing therapeutic strategies is the difficulty in retarding neuronal loss in the diseased brain once the pathologic events leading to neuronal death have started. Therefore, a promising alternative strategy is to maintain a healthy neuronal population in the aging brain for as long as possible. One factor evidently important for neuronal health and function is the optimal supply of nutrients necessary for maintaining normal functioning of the brain. Mechanistic studies, epidemiologic analyses, and randomized controlled intervention trials provide insight to the positive effects of docosahexaenoic acid (DHA) and micronutrients such as the vitamin B family, and vitamins E, C, and D, in helping neurons to cope with aging. These nutrients are inexpensive in use, have virtually no side effects when used at recommended doses, are essential for life, have established modes of action, and are broadly accepted by the general public. This review provides some evidence that the use of vitamins and DHA for the aging population in general, and for individuals at risk in particular, is a viable alternative approach to delaying brain aging and for protecting against the onset of AD pathology.

show abstract

Effect of an antioxidant drink on homocysteine levels in Alzheimer's patients

Cited by 42 publications

References 30 publications

A survey of the protective effects of some commercially available antioxidant supplements in genetically and chemically induced models of oxidative stress in Drosophila melanogaster

A survey of the protective effects of some commercially available antioxidant supplements in genetically and chemically induced models of oxidative stress in Drosophila melanogaster

Antioxidant Plant Polyphenols and Cognitive Disorders

Inadequate supply of vitamins and DHA in the elderly: Implications for brain aging and Alzheimer-type dementia

Contact Info

Product

Resources

About