Effect of an Epidermal Growth Factor-Containing Cream on Postinflammatory Hyperpigmentation After Q-Switched 532-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment

Abstract

Epidermal growth factor-containing creams may be an effective measure to prevent laser treatment-induced PIH in Asian patients.

A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q‐Switched 532‐nm Nd:YAG Laser for Solar Lentigines

“…The mean age was 49.35 ± 11.10 and 52.75 ± 10.67 years in TA and placebo group, respectively. Median (range) disease duration was 10 years in TA group and 8.5 years in placebo group. Most of the patients had Fitzpatrick skin type III or IV, numbering 18 (90%) in TA group and 15 (75%) in placebo group.…”

“…However, it may interfere with the wound‐healing process and increase the risk of infection. Topical application of a cream containing EGF significantly decreased the melanin index and incidence of PIH after QS 532‐nm Nd:YAG laser . Recently, single dose of intradermal TA injection could significantly reduce the risk of developing PIH after QS 532‐nm Nd:YAG laser treatment of SLs on the forearm .…”

The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split‐face randomized controlled study

“…The results showed significant reduction in incidence of PIH and melanin index but nonsignificant reduction in transepidermal water loss in EGF treated side. Then, they proposed that there could be the mechanisms other than promotion of wound healing to prevent the PIH, which may be associated with an inhibitory effect on melanogenesis of EGF …”

“…Then, they proposed that there could be the mechanisms other than promotion of wound healing to prevent the PIH, which may be associated with an inhibitory effect on melanogenesis of EGF. 23 In this study, we treated the patients with fractional ablative CO 2 laser, which targets water, hence causing more damage to keratinocytes, when comparing to the 532-nm-Q-switched Nd:YAG laser. 24 Damaged keratinocytes release proinflammatory mediators, including PGE2, which can increase the size of melanocytes, the number of melanocytic dendrites, enhancing tyrosinase activity and stimulate melanogenesis.…”

Bioactive: A new era of bioactive ingredients in topical formulations for inflammatory dermatoses

“…Topical EGFs have also been used for antiinflammation. A study of 13 subjects undergoing laser treatment for senile lentigines reported that EGF-containing cream reduced postinflammatory hyperpigmentation at 35 days as compared to vehicle (Park, et al 2015).…”