Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

Kawashima, Satoki; Shinkai, Koichi; Suzuki, Masashi

doi:10.4012/dmj.2015-381

Cited by 18 publications

(16 citation statements)

References 38 publications

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“…They have a stable glass-ionomer phase, and fluoride (F − ) release and recharge properties [2][3][4] . In addition to F − , five types of ions (Na + , Al 3+ , BO3 3− , Sr 2+ , and SiO3 2− ) are sustainably released from the filler surface layer 5,6) .…”

Section: Introductionmentioning

confidence: 99%

Optimal dilutions of S-PRG filler eluate for experiments on human gingival fibroblasts <i>in vitro </i>

et al. 2021

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The present study attempted to identify the optimal dilution at which at which the effects of surface reaction-type pre-reacted glassionomer (S-PRG) filler eluate on human gingival fibroblasts (HGF) may be safely examined in vitro. S-PRG filler is a material that releases six ions and exerts strong caries-suppressing effects. We prepared S-PRG filler eluate in which S-PRG filler and α-MEM were mixed as a medium for HGF. This eluate contains six ions that are released from S-PRG filler. All cells died in proliferation experiments on HGF using S-PRG filler eluate, which demonstrated that unless S-PRG filler eluate was diluted, the ion concentration was strongly cytotoxic. S-PRG filler eluate diluted by 1/100 or more with the addition of 2% or more of FBS was safe for use. We herein successfully established the optimal dilution of S-PRG filler eluate at which HGF may be safely examined in vitro.

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Section: Introductionmentioning

confidence: 99%

Optimal dilutions of S-PRG filler eluate for experiments on human gingival fibroblasts <i>in vitro </i>

et al. 2021

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“…The beneficial bioactive properties of the six ions released from S‐PRG filler are believed to favour the clinical application of S‐PRG‐containing materials for direct pulp capping (Kawashima et al . 2016, Takahashi et al . 2019), coating of root surfaces (Satoshi et al .…”

Section: Introductionmentioning

confidence: 99%

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

et al. 2020

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AimTo evaluate the efficacy of a prototype root canal dressing containing surface pre‐reacted glass–ionomer (S‐PRG) fillers on repairing induced periapical lesions in a rat model. Calcium hydroxide [Ca(OH)2] was applied as a comparison in the healing process.MethodologyThe pulp chambers of the maxillary first molars in 64 male Wistar rats aged 16 weeks were opened to induce periapical lesions. After 28 days, the mesial canal of each tooth was prepared, irrigated with 2.5% sodium hypochlorite only (control group: irrigation) or followed by the respective dressing [Ca(OH)2 group, irrigation + Ca(OH)2; S‐PRG group, irrigation + S‐PRG] and restored with composite resin for 3 or 7 days (10/group). Four rats with healthy molars were used as blank controls. Descriptive analysis of the periapical radiographs, haematoxylin and eosin staining and immunohistochemical observation was performed 3 and 7 days after treatment. The periapical grey value, CD68 macrophages and osteoclasts (cathepsin‐K) were quantified and statistically analysed with Tukey’s honest significant difference test. A significant difference was achieved when P values were <0.05.ResultsS‐PRG and Ca(OH)2 dressings were associated with increased periapical grey values and inhibited osteoclast activity at 3 and 7 days; a significant difference in radiographic results and the number of osteoclasts was obtained at 3 and 7 days compared with the control group (P < 0.05). Reparative tissue was observed histologically in the space of the periapical resorbed necrotic area after S‐PRG and Ca(OH)2 treatment for 3 and 7 days. The number of macrophages was significantly decreased at 3 and 7 days in the S‐PRG and Ca(OH)2 specimens when compared with the controls (P < 0.05).ConclusionsIn a rat experimental model, the S‐PRG root canal dressing was comparable to Ca(OH)2 in promoting the healing of experimentally induced periapical lesions. S‐PRG paste has the potential to be used as an alternative intracanal dressing in teeth with apical periodontitis.

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“…Nevertheless, experimental protocols in rat molars vary, particularly with regard to the site of pulpal exposure [ 4 5 6 7 8 9 10 11 12 ]. An approach via the occlusal surface has been reported to be superior to the mesial surface due to the ability to control the size and depth of pulpal exposure [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…An approach via the occlusal surface has been reported to be superior to the mesial surface due to the ability to control the size and depth of pulpal exposure [ 13 ]. In contrast, other studies prepared exposure sites at the mesial aspects of the teeth in various positions, such as the cervical third (with gingivectomy) [ 4 5 6 ], the middle third [ 9 10 ], or the occlusal third (mesial marginal ridge) [ 11 12 ]. The preference for mesial exposure was due to the ease of access in cavity preparations [ 6 ], related to the space available between the incisors and the first molars.…”

Section: Introductionmentioning

confidence: 99%

Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model

et al. 2018

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ObjectivesDirect pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model.Materials and MethodsA total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores.ResultsAt 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed.ConclusionsThe location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

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Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

Cited by 18 publications

References 38 publications

Optimal dilutions of S-PRG filler eluate for experiments on human gingival fibroblasts <i>in vitro </i>

Optimal dilutions of S-PRG filler eluate for experiments on human gingival fibroblasts <i>in vitro </i>

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model

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