Effect of an extract from embryonic neural tissue on the content of dopamine and noradrenaline in explants of the midbrain and medulla of newborn rats

Abstract

It was found that addition of an extract from embryonic neural tissue (ENT), which contained 150 ~ug/ml proteins, to the culture medium favored viability of catecholaminergic neurons in cultured explants of the midbrain and medulla of newborn rats and establishment of contacts among these neurons. Addition of the ENT extract increased the dopamine level, measured at the 3rd-4th days of culturing, in the explants of the midbrain and medulla by 1.5 and 3.8 times, respectively. Similar indices for noradrenaline in the above structures were 2.5-2.6 times. The content of cAMP and cGMP in the explants increased 2.3 and 2.8 times, respectively, already 2-3 h after the ENT extract addition.

Effect of transplantation of embryonic neural tissue on the dynamics of brain edema following experimental craniocerebral trauma

“…both directly in the CCT area and in other, more remote recipient brain areas, was demonstrated [16]. Objective information about the degree of disturbance of the water-electrolyte equilibrium in the brain tissue following various pathological states, in particular CCT, can be obtained using the technique of impedancemetry [171.…”