Effect of an In Vitro Proximal Gastrointestinal Tract on Viability of Commercially Available Equine Probiotics

Berreta, Ana; Kopper, Jamie J.; Alexander, Trevor L.; Kogan, Clark; Burbick, Claire R.

doi:10.1016/j.jevs.2021.103671

Cited by 3 publications

(1 citation statement)

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“…Probiotics, by definition, are live microorganisms, and should remain viable when they reach the intended site of action, which is typically the cecum and/or the colon [24]. Most probiotics originate from fermenting food, an ancient form of preservation ingrained in human societies around the world [25].…”

Section: Rationale For Probiotic Supplements To Eradicate Enterobacterales Carriage In the Gutmentioning

confidence: 99%

The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant Enterobacterales

Hung

Lee

et al. 2021

Antibiotics

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Probiotic supplements have been used to decrease the gut carriage of antimicrobial-resistant Enterobacterales through changes in the microbiota and metabolomes, nutrition competition, and the secretion of antimicrobial proteins. Many probiotics have shown Enterobacterales-inhibiting effects ex vivo and in vivo. In livestock, probiotics have been widely used to eradicate colon or environmental antimicrobial-resistant Enterobacterales colonization with promising efficacy for many years by oral supplementation, in ovo use, or as environmental disinfectants. In humans, probiotics have been used as oral supplements for infants to decease potential gut pathogenic Enterobacterales, and probiotic mixtures, especially, have exhibited positive results. In contrast to the beneficial effects in infants, for adults, probiotic supplements might decrease potentially pathogenic Enterobacterales, but they fail to completely eradicate them in the gut. However, there are several ways to improve the effects of probiotics, including the discovery of probiotics with gut-protection ability and antimicrobial effects, the modification of delivery methods, and the discovery of engineered probiotics. The search for multifunctional probiotics and synbiotics could render the eradication of “bad” Enterobacterales in the human gut via probiotic administration achievable in the future.

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Section: Rationale For Probiotic Supplements To Eradicate Enterobacterales Carriage In the Gutmentioning

confidence: 99%