Effect of an Infection Control Program on the Frequency of Nosocomial Viral Respiratory Infections

Gómez-Villa, Ramiro Jetzabel; Comas‐García, Andreu; López-Rojas, Vicente; Pérez-González, Luis Fernando; Sánchez-Alvarado, Josefina; Salazar-Zaragoza, Rocío; Ruiz-González, Juana M.; Alpuche-Solís, Ángel G.; Noyola, Daniel E.

doi:10.1086/588000

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…Respiratory samples were collected from pediatric subjects as part of research projects carried out to analyze the epidemiology of viral respiratory infections and as part of a hospital-based infection control program [8–11]. The research projects were approved by the corresponding Research and Ethics Committees.…”

Section: Methodsmentioning

confidence: 99%

Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes

Bose

Shrivastava

et al. 2019

PLoS ONE

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Human Parainfluenza viruses (HPIV) type 1 and 3 are important causes of respiratory tract infections in young children globally. HPIV infections do not confer complete protective immunity so reinfections occur throughout life. Since no effective vaccine is available for the two virus subtypes, comprehensive understanding of HPIV-1 and HPIV-3 genetic and epidemic features is important for diagnosis, prevention, and treatment of HPIV-1 and HPIV-3 infections. Relatively few whole genome sequences are available for both HPIV-1 and HPIV-3 viruses, so our study sought to provide whole genome sequences from multiple countries to further the understanding of the global diversity of HPIV at a whole-genome level. We collected HPIV-1 and HPIV-3 samples and isolates from Argentina, Australia, France, Mexico, South Africa, Switzerland, and USA from the years 2003–2011 and sequenced the genomes of 40 HPIV-1 and 75 HPIV-3 viruses with Sanger and next-generation sequencing with the Ion Torrent, Illumina, and 454 platforms. Phylogenetic analysis showed that the HPIV-1 genome is evolving at an estimated rate of 4.97 × 10 −4 mutations/site/year (95% highest posterior density 4.55 × 10 −4 to 5.38 × 10 −4 ) and the HPIV-3 genome is evolving at a similar rate (3.59 × 10 −4 mutations/site/year, 95% highest posterior density 3.26 × 10 −4 to 3.94 × 10 −4 ). There were multiple genetically distinct lineages of both HPIV-1 and 3 circulating on a global scale. Further surveillance and whole-genome sequencing are greatly needed to better understand the spatial dynamics of these important respiratory viruses in humans.

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Section: Methodsmentioning

confidence: 99%

Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes

Bose

Shrivastava

et al. 2019

PLoS ONE

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“…As of the year 2005 a comprehensive program for surveillance and prevention of nosocomial transmission of viral pathogens was established in the pediatric wards of the hospital. 10 On April 2009 this program was expanded to include adults in addition to pediatric patients. This hospital was the reference center for patients with suspected severe influenza infections in our region since the onset of the influenza pandemic.…”

Section: Study Sitementioning

confidence: 99%

Pandemic influenza A(H1N1) 2009 and respiratory syncytial virus associated hospitalizations

Lovato-Salas

Matienzo-Serment

Monjarás‐Ávila

et al. 2010

Journal of Infection

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“…Clinical information and respiratory samples were obtained as part of research protocols approved by the ethics and research committees at participating hospitals, as well as the collaborative Respiratory Virus Surveillance Program. [6][7][8] Informed consent was obtained from parents of participating infants. Clinical and epidemiological characteristics for some of the study populations have previously been described.…”

Section: Methodsmentioning

confidence: 99%

Population-based Influenza and Respiratory Syncytial Virus Hospitalizations and In-hospital Mortality Rates Among Mexican Children Less Than Five Years of Age

Mata-Moreno,

Bernal-Silva,

García-Sepúlveda

et al. 2024

Pediatric Infectious Disease Journal

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Background: Population-based information regarding the impact of respiratory syncytial virus (RSV) and influenza on hospital admissions and mortality is scant for many countries. Methods: Prospective testing of RSV and influenza virus was undertaken in patients <5 years old admitted to hospital with acute respiratory infection (ARI) between July, 2014 and June, 2015, and mortality rates for children living in 3 municipalities in the state of San Luis Potosí were calculated. Results: During the 12-month study period, 790 children living in these municipalities were admitted with ARI. RSV was detected in 245 (31%) and influenza in 47 (5.9%). History of preterm birth was recorded for 112 children on admission. For children <5 years old, ARI-, RSV- and influenza-associated admission rates were 23.2, 7.2 and 1.4 (per 1000 population), respectively. The corresponding admission rates per 1000 infants <1 year old were 78, 25.2 and 4.4. Preterm infant admission rates were 2 times higher than those of term infants. Six children died; RSV was detected in 4 (66.6%) of the deceased, while no deaths were associated with influenza. ARI and RSV in-hospital mortality rates for children <5 years were 0.18 and 0.12 per 1000 population. ARI and RSV mortality rates in preterm infants were 7 and 14 times higher than in term infants, respectively. Conclusions: RSV was associated with both high admission and in-hospital mortality rates in children <5 years old. Specific interventions, such as active or passive immunization, to prevent RSV infections are required to reduce ARI-associated infant mortality.

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Effect of an Infection Control Program on the Frequency of Nosocomial Viral Respiratory Infections

Cited by 9 publications

References 8 publications

Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes

Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes

Pandemic influenza A(H1N1) 2009 and respiratory syncytial virus associated hospitalizations

Population-based Influenza and Respiratory Syncytial Virus Hospitalizations and In-hospital Mortality Rates Among Mexican Children Less Than Five Years of Age

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