Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves

Abstract

The objective of this study was to evaluate the effect of 2 subcutaneous injections of a multimineral preparation, each containing 60 mg of zinc, 10mg of manganese, 5mg of selenium, and 15 mg of copper at 3 and 30 d after birth on immunity, health, and growth of dairy calves during the preweaning period. The study was conducted in upstate New York in 2 commercial dairy farms. A total of 790 Holstein heifer calves were randomly allocated at birth into 1 of 2 treatments: trace mineral supplement (TMS) treated or control. Blood samples were collected at 3, 14, and 35 d after birth to evaluate glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, haptoglobin, and neutrophil and monocyte function. Incidence of diseases and average daily gain was evaluated in the first 50 d of life. At 14 d of life, TMS-treated calves had increased neutrophil activity compared with control calves. Moreover, TMS-treated calves had greater GPx activity on d 14 after birth than control calves. The TMS treatment reduced the incidence of diarrhea (TMS=41.7% vs. control=49.7%) and combined incidence of pneumonia or otitis or both (TMS=41.7% vs. control=49.1%). Additionally, GPx was greater for calves diagnosed with otitis at d 35 after birth. However, calves diagnosed with pneumonia had decreased GPx activity at d 35 after birth. Serum SOD and haptoglobin concentrations were not affected by treatment or disease. Moreover, no effects were observed on average daily gain and survivability between TMS-treated and control calves during the preweaning period. Supplementation with trace minerals at 3 and 30 d of life increased neutrophil function and GPx activity and reduced the incidence of health disorders.

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

“…Although the data are controversial, limited evidence exists on the benefits in children treated for severe malnutrition [15] . Interestingly, in another study, 2 subcutaneous injections of a multimineral preparation containing Zn, Mn, Se, and Cu increased neutrophil function [16] . In the present study, we revealed that serum Zn concentrations were significantly reduced in patients with COM compared with control subjects.…”

Organic selenium supplementation improves growth parameters, immune and antioxidant status of newly received beef cattle

“…Serum Se was determined by an external accredited laboratory using inductively coupled plasma mass spectrometry (ICPMS; Agilent 7500 CX series, Agilent Technologies, Santa Clara, CA, USA), with a procedure according to UNI CEI EN ISO/IEC 17025:2005 standard, following the method reported by van de Wiel (2003). The BHV-1 serum neutralization test was performed according to OIE (2012).…”

“…Se improves phagocytosis in white blood cell populations (Hogan et al, 1990). The improvement of immune cell functioning is likely due to the enhanced antioxidant status (Teixeira et al, 2014). The Se role in enhancing the antioxidant status of the organism is mediated by the Se-dependent glutathione peroxidase (GSH-Px) (Battain and Brumaghim, 2009).…”

Block of mineral salt in the diet of sheep and lambs and their effects on health and performance

“…NDF rate in the diet was reduced (11%), which may have altered protein metabolism and changed creatinine, urea and GGT. In studies with Santa Inês and Dorper breeds, the reference values for lambs in the finishing stage are 0.65 to 1.2 mg/dL for creatinine, 31.67 to 52 mg/dL for urea, and 93 U/L for GGT (MADUREIRA et al, 2013;TEIXEIRA et al, 2014;LIMA et al, 2015). The results presented here show that the lambs used in this study can be assessed as not having any renal alterations, but with hepatic problems.…”