Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions

Rojas, Ana M.; Stewart, Fiona; Smith, K. A.; Soranson, J.A.; Randhawa, V. S.; Stratford, Michael R.L.; Denekamp, Juliana

doi:10.1016/0360-3016(87)90165-9

Cited by 18 publications

(17 citation statements)

References 28 publications

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“…One major factor affecting radioresistance during anaemia seems to be the period of time over which anaemia occurred. Pronounced differences were seen between studies in which anaemia was acutely (Hewitt et al, 1971;Hirst et al, 1984) or chronically (Hirst et al, 1984;Rojas et al, 1987;Joiner et al, 1993) induced. From these data, it seems obvious that physiological adaptation to haematocrit changes plays a role in the effect of anaemia on radiosensitivity.…”

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confidence: 96%

“…Studies on the effects of transfusion on radioresistance have generally shown an improvement in radiotherapy with increases in haemoglobin concentration (Hewitt et al, 1971;Hirst et al, 1984;Rojas et al, 1987). This effect was even seen in a study in which anaemia initially increased the radiosensitivity (Rojas et al, 1987).…”

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confidence: 98%

“…However, the results of these studies are not unanimous, describing an increase in radioresistance (Hewitt et al, 1971;Hill et al, 1972;Hirst et al, 1984;McCormack et al, 1990), no effect on the outcome of radiotherapy (Hirst et al, 1984;Joiner et al, 1993) but also an increase in radiosensitivity (Rojas et al, 1987). One major factor affecting radioresistance during anaemia seems to be the period of time over which anaemia occurred.…”

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confidence: 99%

“…From these data, it seems obvious that physiological adaptation to haematocrit changes plays a role in the effect of anaemia on radiosensitivity. Another factor influencing the results might be the application of irradiation as a single dose or in a fractionated schedule (Hirst et al, 1984;Rojas et al, 1987).…”

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confidence: 99%

“…On the basis of these findings, several studies have investigated the effect of correcting anaemia on sensitivity to radiotherapy (Hewitt et al, 1971;Hill et al, 1972;Hirst et al, 1984;Rojas et al, 1987;Joiner et al, 1993), whereby in most of these studies blood or RBC transfusion was used to compensate for anaemia. Studies on the effects of transfusion on radioresistance have generally shown an improvement in radiotherapy with increases in haemoglobin concentration (Hewitt et al, 1971;Hirst et al, 1984;Rojas et al, 1987).…”

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confidence: 99%

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Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia

Thews

Koenig²,

Dk³

et al. 1998

Br J Cancer

130

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Summary The radiosensitivity of solid tumours in anaemic rats treated with recombinant human erythropoietin (rhEPO, epoetin beta) was studied. Anaemia was induced by a single dose of carboplatin (45 mg kg-' i.v.), resulting in a reduction in the haemoglobin concentration by 30%. In a second group, the development of anaemia was prevented by rhEPO (1000 IU kg-1) administered s.c. three times per week starting 6 days before the carboplatin application. Three days after carboplatin treatment, DS-sarcomas were implanted subcutaneously onto the hind foot dorsum. Neither carboplatin nor rhEPO treatment influenced tumour growth rate. Five days after implantation, tumours were irradiated with a single non-curative dose (10 Gy), resulting in a growth delay with a subsequent regrowth of the tumours. In the rhEPO-treated group, the growth delay lasted significantly longer (9.5 days vs. 4.5 days) and the regrowth was slower (6.0 days vs. 4.1 days) compared with the anaemic group. These data suggest that the correction of chemotherapy-induced anaemia by rhEPO (epoetin beta) treatment increases tumour radiosensitivity, presumably as a result of an improved oxygen supply to tumour tissue.

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confidence: 96%

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confidence: 98%